KNDy neurons as the GnRH pulse generator: Recent studies in ruminants

[1]  S. Han,et al.  Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice. , 2023, Cell reports.

[2]  E. Dubois,et al.  Impact of food restriction on the medio‐basal hypothalamus of intact ewes as revealed by a large‐scale transcriptomics study , 2022, Journal of neuroendocrinology.

[3]  D. Lomet,et al.  The Kisspeptin analogue C6 induces ovulation in jennies. , 2022, Theriogenology.

[4]  L. Xiao,et al.  Effects of kisspeptin-10 on the reproductive performance of sows in a fixed-time artificial insemination programme. , 2022, Animal : an international journal of animal bioscience.

[5]  S. Hileman,et al.  The impact of undernutrition on KNDy (kisspeptin/neurokinin B/dynorphin) neurons in female lambs , 2022, Journal of neuroendocrinology.

[6]  G. Salzano,et al.  A customized long acting formulation of the kisspeptin analog C6 triggers ovulation in anestrus ewe , 2022, Journal of neuroendocrinology.

[7]  Zhao Jiayu,et al.  Immunocastration with gene vaccine (KISS1) induces a cell-mediated immune response in ram testis: A transcriptome evaluation. , 2022, Reproduction in domestic animals = Zuchthygiene.

[8]  R. Goodman,et al.  Neuroendocrine control of gonadotropin‐releasing hormone: Pulsatile and surge modes of secretion , 2022, Journal of neuroendocrinology.

[9]  D. Rowitch,et al.  MC3R links nutritional state to childhood growth and the timing of puberty , 2021, Nature.

[10]  T. Yamamura,et al.  Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats , 2021, The Journal of reproduction and development.

[11]  N. Inoue,et al.  Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction , 2021, Frontiers in Endocrinology.

[12]  R. Cone,et al.  The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia , 2021, Science Translational Medicine.

[13]  Jeffrey R. Sommer,et al.  Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep , 2021, Metabolites.

[14]  Sabine Hessler,et al.  Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron , 2020, bioRxiv.

[15]  S. Ohkura,et al.  Facilitatory and inhibitory role of central amylin administration in the regulation of the gonadotropin-releasing hormone pulse generator activity in goats , 2020, Neuroscience Letters.

[16]  S. Ohkura,et al.  Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats , 2020, The Journal of reproduction and development.

[17]  Xunping Jiang,et al.  Effect of Kisspeptin-54 immunization on performance, carcass characteristics, meat quality and safety of Yiling goats. , 2020, Meat science.

[18]  Casey C Nestor,et al.  Neuronal networks that regulate gonadotropin-releasing hormone/luteinizing hormone secretion during undernutrition: evidence from sheep. , 2020, Domestic animal endocrinology.

[19]  G. Mahmoud,et al.  Kisspeptin Injection Improved the Semen Characteristics and Sperm Rheotaxis in Ossimi Ram. , 2019, Reproduction in domestic animals = Zuchthygiene.

[20]  Liguo Yang,et al.  Immunization with oral KISS1 DNA vaccine inhibits testicular Leydig cell proliferation mainly via the hypothalamic–pituitary–testicular axis and apoptosis-related genes in goats , 2019, Animal biotechnology.

[21]  Nasser S. Abou Khalil,et al.  Reproductive, antioxidant and metabolic responses of Ossimi rams to kisspeptin. , 2019, Theriogenology.

[22]  K. Tsaneva-Atanasova,et al.  The Origin of GnRH Pulse Generation: An Integrative Mathematical-Experimental Approach , 2019, The Journal of Neuroscience.

[23]  J. T. Smith,et al.  Arcuate nucleus kisspeptin response to increased nutrition in rams. , 2019, Reproduction, fertility, and development.

[24]  C. Lents.  Review: kisspeptin and reproduction in the pig. , 2019, Animal : an international journal of animal bioscience.

[25]  M. Beltramo,et al.  Acute and subacute effects of a synthetic kisspeptin analog, C6, on serum concentrations of luteinizing hormone, follicle stimulating hormone, and testosterone in prepubertal bull calves. , 2019, Theriogenology.

[26]  K. Poissenot,et al.  The kisspeptin analog C6 is a possible alternative to PMSG (pregnant mare serum gonadotropin) for triggering synchronized and fertile ovulations in the Alpine goat , 2019, PloS one.

[27]  H. I. Ahmad,et al.  Immunization against Kisspeptin-54 perturb hypothalamic-pituitary-testicular signaling pathway in ram lambs. , 2019, Theriogenology.

[28]  S. Ohkura,et al.  Peripheral administration of κ-opioid receptor antagonist stimulates gonadotropin-releasing hormone pulse generator activity in ovariectomized, estrogen-treated female goats. , 2019, Domestic animal endocrinology.

[29]  Jaswant Singh,et al.  Kisspeptin induces ovulation in heifers under low plasma progesterone concentrations. , 2019, Theriogenology.

[30]  A. Herbison.  The Gonadotropin-Releasing Hormone Pulse Generator. , 2018, Endocrinology.

[31]  L. Coolen,et al.  Evidence That Dynorphin Acts Upon KNDy and GnRH Neurons During GnRH Pulse Termination in the Ewe , 2018, Endocrinology.

[32]  L. Coolen,et al.  KNDy Cells Revisited. , 2018, Endocrinology.

[33]  L. Coolen,et al.  Regulation of GnRH pulsatility in ewes. , 2018, Reproduction.

[34]  L. Coolen,et al.  KNDy Hypothesis for Generation of GnRH Pulses: Evidence from Sheep and Goats , 2018 .

[35]  R. Millar,et al.  Continuous Kisspeptin Restores Luteinizing Hormone Pulsatility Following Cessation by a Neurokinin B Antagonist in Female Sheep , 2018, Endocrinology.

[36]  Xunping Jiang,et al.  Reversibility and safety of KISS1 metastasis suppressor gene vaccine in immunocastration of ram lambs , 2017, Asian-Australasian journal of animal sciences.

[37]  M. Beltramo,et al.  Towards new strategies to manage livestock reproduction using kisspeptin analogs. , 2017, Theriogenology.

[38]  T. Yamamura,et al.  Mapping of KNDy neurons and immunohistochemical analysis of the interaction between KNDy and substance P neural systems in goat , 2017, The Journal of reproduction and development.

[39]  S. Han,et al.  Definition of the hypothalamic GnRH pulse generator in mice , 2017, Proceedings of the National Academy of Sciences.

[40]  Xunping Jiang,et al.  Kisspeptin recombinant oral vaccine: A master gene vaccine inhibiting the reproductive physiology and behavior of ram lambs. , 2017, Vaccine.

[41]  S. Ohkura,et al.  A neurokinin 3 receptor-selective agonist accelerates pulsatile luteinizing hormone secretion in lactating cattle† , 2017, Biology of Reproduction.

[42]  J. Routly,et al.  KNDy neurone activation prior to the LH surge of the ewe is disrupted by LPS. , 2017, Reproduction.

[43]  L. Coolen,et al.  Effects of Season and Estradiol on KNDy Neuron Peptides, Colocalization With D2 Dopamine Receptors, and Dopaminergic Inputs in the Ewe , 2017, Endocrinology.

[44]  Tomomi Tanaka,et al.  Effect of investigational kisspeptin/metastin analog, TAK-683, on luteinizing hormone secretion at different stages of the luteal phase in goats , 2017, The Journal of reproduction and development.

[45]  S. Ohkura,et al.  An administration of TAK-683 at a minimally effective dose for luteinizing hormone stimulation under the absence of the ovary induces luteinizing hormone surge in ovary-intact goats , 2017, The Journal of reproduction and development.

[46]  N. Iijima,et al.  Characterisation of Kiss1r (Gpr54)‐Expressing Neurones in the Arcuate Nucleus of the Female Rat Hypothalamus , 2017, Journal of neuroendocrinology.

[47]  L. Coolen,et al.  Do Substance P and Neurokinin A Play Important Roles in the Control of LH Secretion in Ewes? , 2016, Endocrinology.

[48]  L. Coolen,et al.  Prenatal testosterone exposure decreases colocalization of insulin receptors in kisspeptin/neurokinin B/dynorphin and agouti‐related peptide neurons of the adult ewe , 2016, The European journal of neuroscience.

[49]  A. Delmas,et al.  A synthetic kisspeptin analog that triggers ovulation and advances puberty , 2016, Scientific Reports.

[50]  L. Coolen,et al.  κ-Opioid Receptor Is Colocalized in GnRH and KNDy Cells in the Female Ovine and Rat Brain. , 2016, Endocrinology.

[51]  R. Naz,et al.  Immunocontraception for Animals: Current Status and Future Perspective , 2016, American journal of reproductive immunology.

[52]  N. Rance,et al.  Ablation of KNDy Neurons Results in Hypogonadotropic Hypogonadism and Amplifies the Steroid-Induced LH Surge in Female Rats. , 2016, Endocrinology.

[53]  V. Navarro,et al.  Expanding the Role of Tachykinins in the Neuroendocrine Control of Reproduction. , 2016, Reproduction.

[54]  C. Rose,et al.  The NK3 Receptor Antagonist ESN364 Interrupts Pulsatile LH Secretion and Moderates Levels of Ovarian Hormones Throughout the Menstrual Cycle. , 2015, Endocrinology.

[55]  R. Bertram,et al.  KNDy Neurons Modulate the Magnitude of the Steroid-Induced Luteinizing Hormone Surges in Ovariectomized Rats. , 2015, Endocrinology.

[56]  M. Cieślak,et al.  The effect of short fasting on the hypothalamic neuronal system of kisspeptin in peripubertal female lambs. , 2015, Animal reproduction science.

[57]  S. Ohkura,et al.  Differential changes in luteinizing hormone secretion after administration of the investigational metastin/kisspeptin analog TAK-683 in goats. , 2015, Animal reproduction science.

[58]  Jeremy T. Smith,et al.  Evidence that Neurokinin B Controls Basal Gonadotropin-Releasing Hormone Secretion but Is Not Critical for Estrogen-Positive Feedback in Sheep , 2015, Neuroendocrinology.

[59]  Xunping Jiang,et al.  KISS1 can be used as a novel target for developing a DNA immunocastration vaccine in ram lambs. , 2015, Vaccine.

[60]  S. Ohkura,et al.  Effects of intravenous administration of neurokinin receptor subtype-selective agonists on gonadotropin-releasing hormone pulse generator activity and luteinizing hormone secretion in goats , 2014, The Journal of reproduction and development.

[61]  D. Hazlerigg,et al.  Seasonal Regulation of Reproduction in Mammals , 2015 .

[62]  R. Goodman,et al.  Control of the Ovarian Cycle of the Sheep , 2015 .

[63]  S. Ohkura,et al.  The Effects of Chronic Subcutaneous Administration of an Investigational Kisspeptin Analog, TAK-683, on Gonadotropin-Releasing Hormone Pulse Generator Activity in Goats , 2014, Neuroendocrinology.

[64]  J. Routly,et al.  Kisspeptin, c-Fos and CRFR type 2 co-expression in the hypothalamus after insulin-induced hypoglycaemia. , 2014, Reproduction in domestic animals = Zuchthygiene.

[65]  S. Ohkura,et al.  Ovarian and hormonal responses to follicular phase administration of investigational metastin/kisspeptin analog, TAK-683, in goats. , 2014, Reproduction in domestic animals = Zuchthygiene.

[66]  O. Rønnekleiv,et al.  Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels. , 2014, Cell metabolism.

[67]  P. Monget,et al.  Acute Injection and Chronic Perfusion of Kisspeptin Elicit Gonadotropins Release but Fail to Trigger Ovulation in the Mare1 , 2014, Biology of reproduction.

[68]  S. Ohkura,et al.  Effects of Full-Length Kisspeptin Administration on Follicular Development in Japanese Black Beef Cows , 2013, The Journal of reproduction and development.

[69]  G. Schütz,et al.  Dependence of fertility on kisspeptin–Gpr54 signaling at the GnRH neuron , 2013, Nature Communications.

[70]  S. Ohkura,et al.  Differential Effects of Continuous Exposure to the Investigational Metastin/Kisspeptin Analog TAK-683 on Pulsatile and Surge Mode Secretion of Luteinizing Hormone in Ovariectomized Goats , 2013, The Journal of reproduction and development.

[71]  L. Coolen,et al.  Kisspeptin, neurokinin B, and dynorphin act in the arcuate nucleus to control activity of the GnRH pulse generator in ewes. , 2013, Endocrinology.

[72]  U. Boehm,et al.  Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse. , 2013, Endocrinology.

[73]  M. Sébert,et al.  Gonadotrophin‐Releasing Hormone Release into the Hypophyseal Portal Blood of the Ewe Mirrors Both Pulsatile and Continuous Intravenous Infusion of Kisspeptin: An Insight into Kisspeptin's Mechanism of Action , 2013, Journal of neuroendocrinology.

[74]  T. Yamamura,et al.  Kisspeptin as a master player in the central control of reproduction in mammals: an overview of kisspeptin research in domestic animals. , 2013, Animal science journal = Nihon chikusan Gakkaiho.

[75]  J. P. De Bond,et al.  Kisspeptin Signaling Is Required for the Luteinizing Hormone Response in Anestrous Ewes following the Introduction of Males , 2013, PloS one.

[76]  C. Oliva,et al.  Double‐blind, randomized, placebo‐controlled study of safety, tolerability, pharmacokinetics and pharmacodynamics of TAK‐683, an investigational metastin analogue in healthy men , 2013, British journal of clinical pharmacology.

[77]  T. Yamamura,et al.  Electrophysiological and Morphological Evidence for Synchronized GnRH Pulse Generator Activity Among Kisspeptin/Neurokinin B/Dynorphin A (KNDy) Neurons in Goats , 2012, The Journal of reproduction and development.

[78]  H. Matsumoto,et al.  Development and validation of sensitive sandwich ELISAs for two investigational nonapeptide metastin receptor agonists, TAK-448 and TAK-683. , 2012, Journal of pharmaceutical and biomedical analysis.

[79]  L. Coolen,et al.  Evidence that dopamine acts via kisspeptin to hold GnRH pulse frequency in check in anestrous ewes. , 2012, Endocrinology.

[80]  A. Caraty,et al.  Kisspeptins and the reproductive axis: potential applications to manage reproduction in farm animals. , 2012, Domestic animal endocrinology.

[81]  J. Butler,et al.  Kisspeptin administration to women: a window into endogenous kisspeptin secretion and GnRH responsiveness across the menstrual cycle. , 2012, The Journal of clinical endocrinology and metabolism.

[82]  N. Rance,et al.  Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. , 2012, Endocrinology.

[83]  Jacques Young,et al.  Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies: Physiological, Pathophysiological and Therapeutic Implications , 2012, Neuroendocrinology.

[84]  J. Xu,et al.  Evidence for a role of KISS-1/GPR54 system in decreased luteinizing hormone (LH) secretion in fasted prepubertal ewes , 2012 .

[85]  S. Bloom,et al.  Sexual Dimorphism of Kisspeptin and Neurokinin B Immunoreactive Neurons in the Infundibular Nucleus of Aged Men and Women , 2011, Front. Endocrin..

[86]  A. Sanbuissho,et al.  Involvement of neurokinin receptors in the control of pulsatile luteinizing hormone secretion in rats. , 2011, The Journal of reproduction and development.

[87]  J. Butler,et al.  Kisspeptin resets the hypothalamic GnRH clock in men. , 2011, The Journal of clinical endocrinology and metabolism.

[88]  M. Amstalden,et al.  Kisspeptin activates the hypothalamic-adenohypophyseal-gonadal axis in prepubertal ewe lambs. , 2011, Reproduction.

[89]  L. Coolen,et al.  Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. , 2011, Endocrinology.

[90]  O. Rønnekleiv,et al.  Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels. , 2011, Endocrinology.

[91]  A. Bookout,et al.  Characterization of Kiss1 neurons using transgenic mouse models , 2011, Neuroscience.

[92]  M. Shahab,et al.  Kisspeptin is essential for the full preovulatory LH surge and stimulates GnRH release from the isolated ovine median eminence. , 2011, Endocrinology.

[93]  N. Rance,et al.  Neurokinin B and the hypothalamic regulation of reproduction , 2010, Brain Research.

[94]  Michael N Lehman,et al.  Kisspeptin / Neurokinin B / Dynorphin ( KNDy ) Cells of the Arcuate Nucleus : A Central Node in the Control of Gonadotropin-Releasing Hormone Secretion , 2010 .

[95]  L. Coolen,et al.  Neural Systems Mediating Seasonal Breeding in the Ewe , 2010, Journal of neuroendocrinology.

[96]  S. Ohkura,et al.  Male Effect Pheromone Tickles the Gonadotrophin‐Releasing Hormone Pulse Generator , 2010, Journal of neuroendocrinology.

[97]  M. Sébert,et al.  Insights into the mechanism by which kisspeptin stimulates a preovulatory LH surge and ovulation in seasonally acyclic ewes: potential role of estradiol. , 2010, Domestic animal endocrinology.

[98]  Alda Pereira,et al.  Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells. , 2010, Endocrinology.

[99]  K. Mogi,et al.  Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone Secretion in the Goat , 2010, The Journal of Neuroscience.

[100]  L. Coolen,et al.  The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep. , 2010, Endocrinology.

[101]  S. Lightman,et al.  Kisspeptin Signalling in the Hypothalamic Arcuate Nucleus Regulates GnRH Pulse Generator Frequency in the Rat , 2009, PloS one.

[102]  K. Backholer,et al.  Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe. , 2009, Endocrinology.

[103]  K. Backholer,et al.  Melanocortins Mimic the Effects of Leptin to Restore Reproductive Function in Lean Hypogonadotropic Ewes , 2009, Neuroendocrinology.

[104]  K. Mogi,et al.  Gonadotrophin‐Releasing Hormone Pulse Generator Activity in the Hypothalamus of the Goat , 2009, Journal of neuroendocrinology.

[105]  Donald K. Clifton,et al.  Regulation of Gonadotropin-Releasing Hormone Secretion by Kisspeptin/Dynorphin/Neurokinin B Neurons in the Arcuate Nucleus of the Mouse , 2009, The Journal of Neuroscience.

[106]  L. Kriegsfeld,et al.  Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep. , 2008, Endocrinology.

[107]  L. Coolen,et al.  Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. , 2007, Endocrinology.

[108]  J. T. Smith,et al.  Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes. , 2007, Endocrinology.

[109]  J. T. Smith,et al.  KiSS‐1 Neurones Are Direct Targets for Leptin in the ob/ob Mouse , 2006, Journal of neuroendocrinology.

[110]  S. Ohkura,et al.  Activation of melanocortin receptors accelerates the gonadotropin-releasing hormone pulse generator activity in goats , 2005, Neuroscience Letters.

[111]  M. Ferin,et al.  Central infusion of agouti-related peptide suppresses pulsatile luteinizing hormone release in the ovariectomized rhesus monkey. , 2005, Endocrinology.

[112]  D. Ma,et al.  Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[113]  S. Rhind,et al.  Effects of nutritional status and gonadal steroids on expression of appetite-regulatory genes in the hypothalamic arcuate nucleus of sheep. , 2004, The Journal of endocrinology.

[114]  I. Clarke,et al.  Photoperiod effects on gene expression for hypothalamic appetite-regulating peptides and food intake in the ram. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[115]  I. Clarke,et al.  Long-term alterations in body weight do not affect the expression of melanocortin receptor-3 and -4 mRNA in the ovine hypothalamus , 2001, Neuroscience.

[116]  R. Goodman,et al.  A Subset of Gonadotropin-Releasing Hormone Neurons in the Ovine Medial Basal Hypothalamus Is Activated during Increased Pulsatile Luteinizing Hormone Secretion1. , 1999, Endocrinology.

[117]  T. Adrian,et al.  Sufficiency of postprandial plasma levels of islet amyloid polypeptide for suppression of feeding in rats. , 1998, American journal of physiology. Regulatory, integrative and comparative physiology.

[118]  R. Goodman,et al.  Endogenous opioid peptides control the amplitude and shape of gonadotropin-releasing hormone pulses in the ewe. , 1995, Endocrinology.

[119]  D. Keisler,et al.  Influence of food restriction on neuropeptide-Y, proopiomelanocortin, and luteinizing hormone-releasing hormone gene expression in sheep hypothalami. , 1993, Biology of reproduction.

[120]  R. Unger,et al.  Amylin secretion from the rat pancreas and its selective loss after streptozotocin treatment. , 1990, The Journal of clinical investigation.

[121]  A. Caraty,et al.  Effect of time after castration on secretion of LHRH and LH in the ram. , 1988, Journal of reproduction and fertility.