Development andin vitro assessment of a new two-leaflet replacement heart valve designed using computer-generated bubble surfaces

A two-leaflet replacement heart valve has been developed in which the shape of the leaflets in the closed position approximates that of the surface formed by two coapting symmetrical bubbles under pressure. The transvalvular pressure, open area, regurgitation and transvalvular energy loss of the valve have been measured in a hydromechanical simulation of the left heart. Based on these measurements, the performance exceeds or nearly equals that of the best of the commercially available valves.

[1]  R. Brownlee,et al.  A fascia lata mitral valve based on the `frustum' principle , 1971, Thorax.

[2]  L. Talbot,et al.  A fluid-mechanical study of the closure of heart valves , 1979, Journal of Fluid Mechanics.

[3]  Stress Analysis of Normal Human Aortic Valve Leaflets during Diastole , 1973 .

[4]  P. Gould,et al.  Refined Stress Analysis of Human Aortic Heart Valves , 1976 .

[5]  I. Shbeeb,et al.  The aortic valve , 1984, Diseases of the colon and rectum.

[6]  L N Scotten,et al.  Construction and evaluation of a hydromechanical simulation facility for the assessment of mitral valve prostheses. , 1979, Journal of medical engineering & technology.

[7]  L N Scotten,et al.  In vitro assessment of mitral valve prostheses. , 1980, The Journal of thoracic and cardiovascular surgery.

[8]  R. Racca,et al.  New tilting disc cardiac valve prostheses. In vitro comparison of their hydrodynamic performance in the mitral position. , 1981, The Journal of thoracic and cardiovascular surgery.

[9]  H Reul,et al.  Optimal prosthetic aortic leaflet valve: design parametric and longevity analyses: development of the Avcothane-51 leaflet valve based on the optimum design analysis. , 1977, Journal of biomechanics.

[10]  Ajit P. Yoganathan,et al.  Heart Valve Mechanics , 2008 .

[11]  D. Glancy,et al.  The flexible stent. A new concept in the fabrication of tissue heart valve prostheses. , 1971, The Journal of thoracic and cardiovascular surgery.

[12]  D. Ghista,et al.  Mitral-valve mechanics-stress/strain characteristics of excised leaflets, analysis of its functional mechanics and its medical application , 2006, Medical & Biological Engineering.

[13]  R. Cumming,et al.  Development of seamless tri-leaflet valves. , 1980, Transactions - American Society for Artificial Internal Organs.

[14]  P. J. Drury,et al.  Bicuspid mitral bioprosthesis. , 1981, Thorax.

[15]  Brian J. Bellhouse,et al.  Konrad Witzig Memorial Lecture: Some Fluid Mechanic Theories and Their Application to the Design of Heart Valves and Membrane Lungs , 1980 .

[16]  M. Thubrikar,et al.  Stresses of natural versus prosthetic aortic valve leaflets in vivo. , 1980, The Annals of thoracic surgery.

[17]  Y. Missirlis,et al.  Aortic valve mechanics. Part II: a stress analysis of the porcine aortic valve leaflets in diastole. , 1978, Biomaterials, medical devices, and artificial organs.