Reversing the deleterious effects of α2-antiplasmin on tissue plasminogen activator therapy improves outcomes in experimental ischemic stroke

[1]  K. Okada,et al.  Involvement of α2‐antiplasmin in dendritic growth of hippocampal neurons , 2013, Journal of neurochemistry.

[2]  M. Chimowitz.  Endovascular treatment for acute ischemic stroke--still unproven. , 2013, The New England journal of medicine.

[3]  Andreas Meisel,et al.  Do stroke models model stroke? , 2012, Disease Models & Mechanisms.

[4]  G. Donnan,et al.  How to make better use of thrombolytic therapy in acute ischemic stroke , 2011, Nature Reviews Neurology.

[5]  Gregory W Albers,et al.  Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials , 2010, The Lancet.

[6]  A. Folsom,et al.  Novel Hemostatic Factor Levels and Risk of Ischemic Stroke: The Atherosclerosis Risk in Communities (ARIC) Study , 2010, Cerebrovascular Diseases.

[7]  A. Houng,et al.  Platelet Dense-Granule Secretion Plays a Critical Role in Thrombosis and Subsequent Vascular Remodeling in Atherosclerotic Mice , 2009, Circulation.

[8]  A. Houng,et al.  Fibrinolysis is amplified by converting α2‐antiplasmin from a plasmin inhibitor to a substrate , 2007, Journal of thrombosis and haemostasis : JTH.

[9]  D. Vivien,et al.  Mouse Model of In Situ Thromboembolic Stroke and Reperfusion , 2007, Stroke.

[10]  S. Doré,et al.  Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice , 2007, Journal of neuroscience research.

[11]  J. Koziol,et al.  Recanalization and stroke outcome. , 2007, Circulation.

[12]  N. Booth,et al.  TAFIa, PAI‐1 and α2‐antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots , 2007, Journal of thrombosis and haemostasis : JTH.

[13]  J. Montaner,et al.  Hemostatic markers of recanalization in patients with ischemic stroke treated with rt-PA , 2005, Neurology.

[14]  K. Hajjar,et al.  Molecular mechanisms of fibrinolysis , 2005, British journal of haematology.

[15]  O. Kozawa,et al.  α2‐Antiplasmin plays a significant role in acute pulmonary embolism , 2003 .

[16]  E. Lo,et al.  Blood-Brain Barrier Disruption and Matrix Metalloproteinase-9 Expression During Reperfusion Injury: Mechanical Versus Embolic Focal Ischemia in Spontaneously Hypertensive Rats , 2002, Stroke.

[17]  G. Mies,et al.  Effect of Thrombolysis on the Dynamics of Infarct Evolution After Clot Embolism of Middle Cerebral Artery in Mice , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[18]  K. Hossmann,et al.  Recombinant tissue-plasminogen activator-induced thrombolysis after cerebral thromboembolism in mice , 2000, Acta Neuropathologica.

[19]  P. Carmeliet,et al.  Role of plasminogen system components in focal cerebral ischemic infarction: a gene targeting and gene transfer study in mice. , 1999, Circulation.

[20]  D. Collen,et al.  Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. , 1999, Blood.

[21]  A. Houng,et al.  The contribution of activated factor XIII to fibrinolytic resistance in experimental pulmonary embolism. , 1999, Circulation.

[22]  A. Houng,et al.  Alpha 2-antiplasmin causes thrombi to resist fibrinolysis induced by tissue plasminogen activator in experimental pulmonary embolism. , 1997, Circulation.

[23]  S. Tsirka,et al.  An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus , 1997, The Journal of Neuroscience.

[24]  J. Hirsh,et al.  Alpha 2-antiplasmin supplementation inhibits tissue plasminogen activator-induced fibrinogenolysis and bleeding with little effect on thrombolysis. , 1993, The Journal of clinical investigation.

[25]  G. Boysen,et al.  Reduction of Infarct Volume and Mortality by Thrombolysis in a Rat Embolic Stroke Model , 1992, Stroke.

[26]  G. Reed,et al.  Inhibition of clot-bound alpha 2-antiplasmin enhances in vivo thrombolysis. , 1990, Circulation.

[27]  R A Swanson,et al.  A Semiautomated Method for Measuring Brain Infarct Volume , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[28]  G. Reed,et al.  Synergistic fibrinolysis: combined effects of plasminogen activators and an antibody that inhibits alpha 2-antiplasmin. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[29]  T. Kirino,et al.  Proximal occlusion of the middle cerebral artery in C57Black6 mice: relationship of patency of the posterior communicating artery, infarct evolution, and animal survival. , 2004, Journal of neurosurgery.