PIK3CA Mutations and PTEN Loss Correlate with Similar Prognostic Factors and Are Not Mutually Exclusive in Breast Cancer
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L. Skoog | O. Stål | B. Nordenskjöld | L. Rutqvist | Liza Alkhori | Lars Erik Rutqvist | B. Olsson | G. Pérez-Tenorio | Birgit Olsson | Lambert Skoog | Liza Alkhori | Gizeh Pérez-Tenorio | Marie Ahnström Waltersson | Bo Nordenskjöld | Olle Stål | M. A. Waltersson
[1] M. H. Cobb,et al. Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338 , 2000, Current Biology.
[2] K. Kirschner,et al. Amplification of HSD17B1 and ERBB2 in primary breast cancer , 2003, Oncogene.
[3] Wayne A. Phillips,et al. Mutation of the PIK3CA Gene in Ovarian and Breast Cancer , 2004, Cancer Research.
[4] Suk Woo Nam,et al. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas , 2005, Oncogene.
[5] J. Ptak,et al. High Frequency of Mutations of the PIK3CA Gene in Human Cancers , 2004, Science.
[6] O. Stål,et al. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients , 2002, British Journal of Cancer.
[7] S. Pinder,et al. The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome , 2004, The Journal of pathology.
[8] Olle Stål,et al. Akt kinases in breast cancer and the results of adjuvant therapy , 2003, Breast Cancer Research.
[9] K. Yoshida,et al. Phosphoinositide 3-kinase accelerates necrotic cell death during hypoxia. , 2001, The Biochemical journal.
[10] L. Skoog,et al. c-erbB-2 expression and benefit from adjuvant chemotherapy and radiotherapy of breast cancer. , 1995, European Journal of Cancer.
[11] L. Murphy,et al. Phospho-Serine-118 Estrogen Receptor-α Detection in Human Breast Tumors in Vivo , 2004, Clinical Cancer Research.
[12] Carlo Rago,et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. , 2005, Cancer cell.
[13] E. Tokunaga,et al. The association between Akt activation and resistance to hormone therapy in metastatic breast cancer. , 2006, European journal of cancer.
[14] Simak Ali,et al. Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor α , 2001, The Journal of Biological Chemistry.
[15] Hiroyuki Konishi,et al. The PIK3CA gene is mutated with high frequency in human breast cancers , 2004, Cancer biology & therapy.
[16] Frank McCormick,et al. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. , 2005, Cancer research.
[17] Xin Huang,et al. Somatic mutation and gain of copy number of PIK3CA in human breast cancer , 2005, Breast Cancer Research.
[18] Magnus Bosse,et al. Regulation of Raf-Akt Cross-talk , 2002, The Journal of Biological Chemistry.
[19] C. Downes,et al. PTEN function: how normal cells control it and tumour cells lose it. , 2004, The Biochemical journal.
[20] C. Dive,et al. Comparison of phosphatidylinositol‐3‐kinase signalling within a panel of human colorectal cancer cell lines with mutant or wild‐type PIK3CA , 2005, FEBS letters.
[21] L. Skoog,et al. Role of cyclin D1 in ErbB2-positive breast cancer and tamoxifen resistance , 2005, Breast Cancer Research and Treatment.
[22] M. Loda,et al. The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells , 2005 .
[23] B. Park,et al. Mutation of the PIK3CA oncogene in human cancers , 2006, British Journal of Cancer.
[24] P. Vogt,et al. Cancer-specific mutations in PIK3CA are oncogenic in vivo , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[25] J E Paciga,et al. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. , 2001, The American journal of pathology.
[26] J. Lee,et al. Reduced PTEN Expression Is Associated With Poor Outcome and Angiogenesis in Invasive Ductal Carcinoma of the Breast , 2004, Applied immunohistochemistry & molecular morphology : AIMM.
[27] S. Johnston. Targeting downstream effectors of epidermal growth factor receptor/HER2 in breast cancer with either farnesyltransferase inhibitors or mTOR antagonists. , 2006, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
[28] M. Mansukhani,et al. Reduced expression of PTEN correlates with breast cancer progression. , 2002, Human pathology.
[29] T. Waldman,et al. PTEN Gene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells , 2004, Cancer Research.
[30] L. Skoog,et al. Radiotherapy, chemotherapy, and tamoxifen as adjuncts to surgery in early breast cancer: a summary of three randomized trials. , 1989, International journal of radiation oncology, biology, physics.
[31] M. Mori,et al. Reduced Expression of PTEN Protein and Its Prognostic Implications in Invasive Ductal Carcinoma of the Breast , 2005, Oncology.
[32] T. Fujimiya,et al. Phosphoinositide 3-kinase accelerates autophagic cell death during glucose deprivation in the rat cardiomyocyte-derived cell line H9c2 , 2003, Oncogene.
[33] L. Murphy,et al. Phospho-Serine-118 Estrogen Receptor-α Expression Is Associated with Better Disease Outcome in Women Treated with Tamoxifen , 2004, Clinical Cancer Research.
[34] L. Mulligan,et al. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. , 1999, The American journal of pathology.
[35] S. Schwartz,et al. The prevalence of PIK3CA mutations in gastric and colon cancer. , 2005, European journal of cancer.
[36] Hoguen Kim,et al. Serum withdrawal kills U937 cells by inducing a positive mutual interaction between reactive oxygen species and phosphoinositide 3-kinase. , 2005, Cellular signalling.
[37] Hanina Hibshoosh,et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. , 2005, Cancer research.
[38] J. Garcia-conde,et al. Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues. , 2001, European journal of cancer.
[39] A. Marchetti,et al. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma , 2006, The Journal of pathology.
[40] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[41] J. Testa,et al. Activation of AKT kinases in cancer: implications for therapeutic targeting. , 2005, Advances in cancer research.
[42] Y. Chiew,et al. Expression of c‐erbB receptors, heregulin and oestrogen receptor in human breast cell lines , 2000, International journal of cancer.
[43] A. Lash,et al. Frequent Mutation of the PIK3CA Gene in Ovarian and Breast Cancers , 2005, Clinical Cancer Research.
[44] P. Vogt,et al. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[45] B. Iacopetta,et al. PIK3CA mutations in breast cancer are associated with poor outcome , 2006, Breast Cancer Research and Treatment.
[46] P. Depowski,et al. Loss of Expression of the PTEN Gene Protein Product Is Associated with Poor Outcome in Breast Cancer , 2001, Modern Pathology.
[47] Takashi Kumagai,et al. PTEN promoter is methylated in a proportion of invasive breast cancers , 2004, International journal of cancer.