Classifying Nucleic Acid Sub-Sequences as Introns or Exons Using Genetic Programming

An evolutionary computation technique, genetic programming, created programs that classify messenger RNA sequences into one of two classes: (1) the sequence is expressed as (part of) a protein (an exon), or (2) not expressed as protein (an intron).

[1]  Yin Xu,et al.  An Improved System for Exon Recognition and Gene Modeling in Human DNA Sequence , 1994, ISMB.

[2]  L Roberts,et al.  GRAIL seeks out genes buried in DNA sequence. , 1991, Science.

[3]  Simon Handley,et al.  Predicting Whether Or Not a 60-Base DNA Sequence Contains a Centrally-Located Splice Site Using Genetic Programming , 1995 .

[4]  Simon Handley,et al.  Automated learning of a detector for the cores of /spl alpha/-helices in protein sequences via genetic programming , 1994, Proceedings of the First IEEE Conference on Evolutionary Computation. IEEE World Congress on Computational Intelligence.

[5]  Simon Handley,et al.  Automated Learning of a Detector for alpha-Helices in Protein Sequences via Genetic Programming , 1993, ICGA.

[6]  John W. Backus,et al.  Can programming be liberated from the von Neumann style?: a functional style and its algebra of programs , 1978, CACM.

[7]  John R. Koza,et al.  Genetic Programming: The Movie , 1992 .

[8]  E. Uberbacher,et al.  Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Simon Handley.  The Prediction of the Degree of Exposure to Solvent of Amino Acid Residues Via Genetic Programming , 1994, ISMB.

[10]  S. Handley.  Predicting whether or not a nucleic acid sequence is an E. coli promoter region using genetic programming , 1995, Proceedings First International Symposium on Intelligence in Neural and Biological Systems. INBS'95.

[11]  M. Singer,et al.  Genes and Genomes: A Changing Perspective , 1990 .

[12]  John R. Koza,et al.  Evolution of a Computer Program for Classifying Protein Segments as Transmembrane Domains Using Genetic Programming , 1994, ISMB.

[13]  A. Lapedes,et al.  Application of neural networks and other machine learning algorithms to DNA sequence analysis , 1988 .

[14]  John R. Koza,et al.  Genetic programming - on the programming of computers by means of natural selection , 1993, Complex adaptive systems.