Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line

Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.

[1]  BagulMukta,et al.  Crude Garlic Extract Inhibits Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis of Cancer Cells In Vitro. , 2015 .

[2]  N. Li,et al.  Apoptosis of human gastric cancer cells line SGC 7901 induced by garlic-derived compound S-allylmercaptocysteine (SAMC). , 2013, European review for medical and pharmacological sciences.

[3]  Y. Wong,et al.  S-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions. , 2011, Cancer letters.

[4]  N. Druesne-Pecollo,et al.  Modulation of histone acetylation by garlic sulfur compounds. , 2011, Anti-cancer agents in medicinal chemistry.

[5]  Y. Wong,et al.  Identification of a novel function of Id-1 in mediating the anticancer responses of SAMC, a water-soluble garlic derivative, in human bladder cancer cells. , 2010, Molecular medicine reports.

[6]  P. Bénit,et al.  Life with or without AIF. , 2010, Trends in biochemical sciences.

[7]  H. Cheung,et al.  Garlic-Derived S-allylmercaptocysteine Is a Novel In vivo Antimetastatic Agent for Androgen-Independent Prostate Cancer , 2007, Clinical Cancer Research.

[8]  Kazuo T. Suzuki,et al.  Liquid chromatography–mass spectrometry (LC–MS): a powerful combination for selenium speciation in garlic (Allium sativum) , 2006, Analytical and bioanalytical chemistry.

[9]  A. Mitchell,et al.  Recent trends in use of herbal and other natural products. , 2005, Archives of internal medicine.

[10]  K. Vermeulen,et al.  The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer , 2003, Cell proliferation.

[11]  J. Milner,et al.  Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation. , 2001, The Journal of nutrition.

[12]  J. Tyson,et al.  High-performance liquid chromatography of selenoamino acids and organo selenium compounds. Speciation by inductively coupled plasma mass spectrometry. , 1997, Journal of chromatography. A.

[13]  J. Milner,et al.  Dietary components modify the ability of garlic to suppress 7,12-dimethylbenz(a)anthracene-induced mammary DNA adducts. , 1996, The Journal of nutrition.

[14]  B. G. Hughes,et al.  Characterization of the Formation of Allicin and Other Thiosulfinates from Garlic , 1992, Planta medica.

[15]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[16]  Mukta Bagul,et al.  Crude Garlic Extract Inhibits Cell Proliferation and Induces Cell Cycle Arrest and Apoptosis of Cancer Cells In Vitro. , 2015, Journal of medicinal food.

[17]  C. Fimognari,et al.  Anticancer Mechanism of Sulfur-Containing Compounds. , 2015, The Enzymes.

[18]  A. Anagnostou,et al.  S-allylmercaptocysteine inhibits cell proliferation and reduces the viability of erythroleukemia, breast, and prostate cancer cell lines. , 1997, Nutrition and cancer.

[19]  Essentiality of copper in humans. , 1987, Nutrition reviews.

[20]  A. B. Hanley,et al.  The genus Allium. Part 2. , 1985, Critical reviews in food science and nutrition.

[21]  A. B. Hanley,et al.  The genus Allium--Part 1. , 1985, Critical reviews in food science and nutrition.