This article optimizes the design and configuration of algal biofuel supply chain networks (SCN) under economic and environmental objectives. Minimization of the total supply chain cost and the total life cycle greenhouse gas emission are the economic and environmental objectives, respectively. The SCN has been modeled by a multiobjective mixed integer linear programming approach which incorporates multiple production pathways and time periods, seasonality factors, water evaporation, recycling opportunities, and other major traits of the algal biofuel SCN. The model determines the optimal strategic and tactical level decisions of all SCN echelons. A fuzzy solution-based e-constraint method has been utilized to obtain Pareto-optimal solutions that illustrate the trade-off between economic and environmental objectives. The performance of the model has been assessed in a case study carried out in seven states of the U.S which intends to develop the algal biofuel SCN from the year 2018 to the year 2024. Essen...