Visible Laser Desorption/Ionization Mass Spectrometry Using Gold Nanorods

In this report, we demonstrate the novel application of gold nanorods in the laser desorption/ionization mass spectrometry. The gold nanorod substrate was fabricated by electrodepositing the gold into the pores of the porous alumina template. The embedded nanorods with diameter of ∼15 nm were exposed to the surface by partial removal of the alumina template. The vertically aligned gold nanorods were irradiated by a frequency-doubled/-tripled Nd:YAG laser and the desorption/ionization was found to be favored by the use of 532 nm visible laser, which is in the range of the localized surface plasmon resonance. The present technique offers a potential analytical method for the low-molecular-weight analytes which are rather difficult to handle in organic matrix-assisted laser desorption/ionization mass spectrometry.

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