Irgm1 regulates metabolism and function in T cell subsets

[1]  Wan-chi Lin,et al.  IRGM1 links mitochondrial quality control to autoimmunity , 2020, Nature Immunology.

[2]  A. Rudensky,et al.  Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity , 2020, Science.

[3]  N. Yosef,et al.  Oleic acid restores suppressive defects in tissue-resident FOXP3 Tregs from patients with multiple sclerosis , 2021 .

[4]  Nancie J. MacIver,et al.  Targeting T cell oxidative metabolism to improve influenza survival in a mouse model of obesity , 2020, International Journal of Obesity.

[5]  Hongwei Xu,et al.  IRGM promotes the PINK1‐mediated mitophagy through the degradation of Mitofilin in SH‐SY5Y cells , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  S. Chattopadhyay,et al.  Autoimmunity gene IRGM suppresses cGAS‐STING and RIG‐I‐MAVS signaling to control interferon response , 2020, EMBO reports.

[7]  S. Cai,et al.  Fatty Acid Oxidation Controls CD8+ Tissue-Resident Memory T-cell Survival in Gastric Adenocarcinoma , 2020, Cancer Immunology Research.

[8]  Graham M Lord,et al.  Regulatory T-cell therapy in Crohn’s disease: challenges and advances , 2020, Gut.

[9]  D. Farber Form and function for T cells in health and disease , 2019, Nature reviews. Immunology.

[10]  Ajay S. Gulati,et al.  Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium , 2019, bioRxiv.

[11]  S. Chauhan,et al.  The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy , 2019, Molecular cell.

[12]  B. Moran,et al.  Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis , 2019, Front. Immunol..

[13]  M. Kaplan,et al.  Effector T Helper Cell Subsets in Inflammatory Bowel Diseases , 2018, Front. Immunol..

[14]  H. Waldmann,et al.  The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival , 2018, Front. Immunol..

[15]  L. Figueiredo Faculty Opinions recommendation of HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. , 2017 .

[16]  O. Ilkayeva,et al.  Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages* , 2017, The Journal of Biological Chemistry.

[17]  Y. Ni,et al.  Variants in the autophagy-related gene IRGM confer susceptibility to non-alcoholic fatty liver disease by modulating lipophagy. , 2016, Journal of hepatology.

[18]  J. Coers,et al.  Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease. , 2016, Journal of molecular biology.

[19]  J. Helms,et al.  Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection , 2016, BMC Biology.

[20]  J. Locasale,et al.  Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. , 2015, The Journal of clinical investigation.

[21]  A. Bittner,et al.  Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation , 2014, Proceedings of the National Academy of Sciences.

[22]  M. Birnbaum,et al.  Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. , 2014, Immunity.

[23]  J. Rathmell,et al.  The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. , 2014, Cell metabolism.

[24]  Teruo Sakamoto,et al.  Autophagy-Related IRGM Polymorphism Is Associated with Mortality of Patients with Severe Sepsis , 2014, PloS one.

[25]  J. Rathmell,et al.  Leptin Metabolically Licenses T Cells for Activation To Link Nutrition and Immunity , 2014, The Journal of Immunology.

[26]  Ajay S. Gulati,et al.  Irgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation. , 2013, American journal of physiology. Gastrointestinal and liver physiology.

[27]  J. Rathmell,et al.  Metabolic regulation of T lymphocytes. , 2013, Annual review of immunology.

[28]  F. Marelli-Berg,et al.  Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T‐cell‐mediated immunity , 2012, Immunology.

[29]  Zhenwu Lin,et al.  Mutations in IRGM Are Associated With More Frequent Need for Surgery in Patients With Ileocolonic Crohn's Disease , 2012, Diseases of the colon and rectum.

[30]  G. V. D. van der Windt,et al.  Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. , 2012, Immunity.

[31]  J. Qin,et al.  Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. , 2011, Blood.

[32]  J. Rathmell,et al.  Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets , 2011, The Journal of Immunology.

[33]  E. Graviss,et al.  Polymorphic Allele of Human IRGM1 Is Associated with Susceptibility to Tuberculosis in African Americans , 2011, PloS one.

[34]  E. White,et al.  Human IRGM Regulates Autophagy and Its Cell-Autonomous Immunity Functions Through Mitochondria , 2010, Nature Cell Biology.

[35]  G. Yancopoulos,et al.  Producing fully ES cell-derived mice from eight-cell stage embryo injections. , 2010, Methods in enzymology.

[36]  S. Niemann,et al.  Autophagy Gene Variant IRGM −261T Contributes to Protection from Tuberculosis Caused by Mycobacterium tuberculosis but Not by M. africanum Strains , 2009, PLoS pathogens.

[37]  Russell G. Jones,et al.  Enhancing CD8 T-cell memory by modulating fatty acid metabolism , 2009, Nature.

[38]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[39]  A. Andriulli,et al.  Polymorphism of the IRGM Gene Might Predispose to Fistulizing Behavior in Crohn's Disease , 2009, The American Journal of Gastroenterology.

[40]  D. Chaussabel,et al.  The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death , 2008, Nature Immunology.

[41]  T. Merriman,et al.  Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort , 2008, Genes and Immunity.

[42]  J. Rathmell,et al.  Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways1 , 2008, The Journal of Immunology.

[43]  A. Sher,et al.  The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation. , 2008, Cell stem cell.

[44]  T. Oliver,et al.  Impaired Macrophage Function Underscores Susceptibility to Salmonella in Mice Lacking Irgm1 (LRG-47)1 , 2007, The Journal of Immunology.

[45]  Alastair Forbes,et al.  Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility , 2007, Nature Genetics.

[46]  Simon C. Potter,et al.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls , 2007, Nature.

[47]  G. Taylor IRG proteins: key mediators of interferon‐regulated host resistance to intracellular pathogens , 2007, Cellular microbiology.

[48]  A. Sher,et al.  p47 GTPases Regulate Toxoplasma gondii Survival in Activated Macrophages , 2005, Infection and Immunity.

[49]  T. Giese,et al.  Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. , 2005, Gastroenterology.

[50]  V. Deretic,et al.  Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages , 2004, Cell.

[51]  J. Mckinney,et al.  Immune control of tuberculosis by IFN-gamma-inducible LRG-47. , 2003, Science.

[52]  C. Hunter Faculty Opinions recommendation of Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. , 2001 .