Canine epidermolysis bullosa acquisita: circulating autoantibodies target the aminoterminal non-collagenous (NC1) domain of collagen VII in anchoring fibrils.

The classification of autoimmune blistering skin diseases is based on the skin antigen(s) targeted by pathogenic autoantibodies. In humans and dogs, there is increasing evidence that autoimmune subepidermal bullous diseases represent different nosological entities. This study establishes the existence of the canine equivalent of epidermolysis bullosa acquisita (EBA) in humans. Canine EBA, like the inflammatory variant of its human counterpart, is characterized by spontaneous vesicles arising from an inflammatory eruption. Dermo-epidermal separation occurs in association with neutrophilic infiltration in the superficial dermis. Tissue-fixed and circulating IgA and IgG autoantibodies specific for the lower basement membrane zone can be detected by immunofluorescence methods. Using immunoelectron microscopy, autoantibodies are shown to target the distal end of anchoring fibrils in the sublamina densa. ELISA and immunoblotting utilizing eukaryotically expressed recombinant collagen VII subdomains confirm that the circulating autoantibodies are specific for the aminoterminal globular non-collagenous NC1 domain of type VII collagen.

[1]  J. Ortonne,et al.  Absent expression of collagen XVII (BPAG2, BP180) in canine familial localized junctional epidermolysis bullosa. , 1997, Veterinary dermatology.

[2]  Mei Chen,et al.  Development of an ELISA for rapid detection of anti-type VII collagen autoantibodies in epidermolysis bullosa acquisita. , 1997, The Journal of investigative dermatology.

[3]  J. Nicolas,et al.  Identification of a 168-kDa mucosal antigen in a subset of patients with cicatricial pemphigoid. , 1996, The Journal of investigative dermatology.

[4]  H. Shimizu,et al.  An acquired bullous dermatosis due to an autoimmune reaction against uncein , 1996, The British journal of dermatology.

[5]  I. Naito,et al.  Identification of a 450-kDa human epidermal autoantigen as a new member of the plectin family. , 1996, The Journal of investigative dermatology.

[6]  J. Hanifin,et al.  Abnormal IL-4 gene expression by atopic dermatitis T lymphocytes is reflected in altered nuclear protein interactions with IL-4 transcriptional regulatory element. , 1996, The Journal of investigative dermatology.

[7]  E. Bauer,et al.  Polymorphism analysis of type VII collagen immunodominant epitopes in patients with epidermolysis bullosa acquisita , 1996 .

[8]  L. David,et al.  Dermatose bulleuse à IgA linéaire de l'enfant avec autoanticorps dirigés contre l'antigène 180 kDa de la pemphigoïde , 1996 .

[9]  R. Burgeson,et al.  LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells. , 1996, The Journal of investigative dermatology.

[10]  H. Shimizu,et al.  Coexistence of psoriasis and an unusual IgG‐mediated subepidermal bullous dermatosis: identification of a novel 200‐kDa lower lamina lucida target antigen , 1996, The British journal of dermatology.

[11]  H. Shimizu,et al.  A case of linear IgA buUous dermatosis with IgA anti‐type VII collagen autoantibodies , 1996, The British journal of dermatology.

[12]  M. Komine,et al.  A case of generalized pustular psoriasis followed by bullous disease: and atypical case of bullous pemphigoid or a novel bullous disease? , 1996, The British journal of dermatology.

[13]  R. Burgeson,et al.  Anti-basement membrane autoantibodies in patients with anti-epiligrin cicatricial pemphigoid bind the alpha subunit of laminin 5. , 1995, The Journal of investigative dermatology.

[14]  J. Bonifas,et al.  Keratin 14 gene mutations in patients with epidermolysis bullosa simplex. , 1995, The Journal of investigative dermatology.

[15]  J. C. Jones,et al.  Canine Bullous Pemphigoid (BP): Identification of the 180-kd Canine BP Antigen by Circulating Autoantibodies , 1995, Veterinary pathology.

[16]  N. Monteiro-Riviere,et al.  Indirect Immunohistochemistry and Immunoelectron Microscopy Distribution of Eight Epidermal-Dermal Junction Epitopes in the Pig and in Isolated Perfused Skin Treated with Bis (2-Chloroethyl) Sulfide , 1995, Toxicologic pathology.

[17]  W. James,et al.  Passive transfer of autoantibodies from a patient with mutilating epidermolysis bullosa acquisita induces specific alterations in the skin of neonatal mice. , 1995, Archives of dermatology.

[18]  R. Briggaman,et al.  Immunodominant autoepitopes of type VII collagen are short, paired peptide sequences within the fibronectin type III homology region of the noncollagenous (NC1) domain. , 1995, The Journal of investigative dermatology.

[19]  D. Jabs,et al.  Antiepiligrin cicatricial pemphigoid. A subepithelial bullous disorder. , 1994, Archives of dermatology.

[20]  A. Giannetti,et al.  Linear IgA bullous dermatosis with autoantibodies to a 290 kd antigen of anchoring fibrils. , 1994, Journal of the American Academy of Dermatology.

[21]  S. Imamura,et al.  Epitope mapping for epidermolysis bullosa acquisita autoantibody by molecularly cloned cDNA for type VII collagen. , 1994, The Journal of investigative dermatology.

[22]  W. Parks,et al.  92-kD gelatinase is produced by eosinophils at the site of blister formation in bullous pemphigoid and cleaves the extracellular domain of recombinant 180-kD bullous pemphigoid autoantigen. , 1994, The Journal of clinical investigation.

[23]  K. Cooper,et al.  A novel immune-mediated subepidermal bullous dermatosis characterized by IgG autoantibodies to a lower lamina lucida component. , 1994, Archives of dermatology.

[24]  J. Bystryn,et al.  Identification of a novel basement membrane antigen (p84) defined by sera with antibodies to both the epidermal and dermal side of split skin. , 1994, The Journal of investigative dermatology.

[25]  S. Fujiwara,et al.  A new bullous pemphigoid antigen. , 1994, Dermatology.

[26]  P. Santoianni,et al.  Drug-induced cutaneous porphyria. , 1993, Clinics in dermatology.

[27]  J. Uitto,et al.  Epitope mapping of type VII collagen. Identification of discrete peptide sequences recognized by sera from patients with acquired epidermolysis bullosa. , 1993, The Journal of clinical investigation.

[28]  R. Burgeson.  Type VII collagen, anchoring fibrils, and epidermolysis bullosa. , 1993, The Journal of investigative dermatology.

[29]  D. Woodley,et al.  Identification and partial characterization of a novel 105-kDalton lower lamina lucida autoantigen associated with a novel immune-mediated subepidermal blistering disease. , 1993, The Journal of investigative dermatology.

[30]  R. Isseroff,et al.  In vitro HPV-11 infection of human foreskin. , 1993, The Journal of investigative dermatology.

[31]  T. Kageshita,et al.  A Case of Subepidermal Blister Disease Associated with Autoantibody against 450 kD Protein , 1992, The Journal of dermatology.

[32]  R. Briggaman,et al.  Immunofluorescence on split skin for the detection and differentiation of basement membrane zone autoantibodies. , 1992, Journal of the American Academy of Dermatology.

[33]  W. Stolz,et al.  In situ localization of IgG in epidermolysis bullosa acquisita by immunogold technique. , 1992, Journal of the American Academy of Dermatology.

[34]  W. Gammon.  Epidermolysis bullosa acquisita: a disease of autoimmunity to type VII collagen. , 1991, Journal of autoimmunity.

[35]  J. Zone,et al.  Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis. , 1990, The Journal of clinical investigation.

[36]  S. Tyring,et al.  The presence of intra-lamina lucida blister formation in epidermolysis bullosa acquisita: possible role of leukocytes. , 1989, The Journal of investigative dermatology.

[37]  R. Burgeson,et al.  Epidermolysis bullosa acquisita antigen is the globular carboxyl terminus of type VII procollagen. , 1988, The Journal of clinical investigation.

[38]  J. Fine,et al.  Bullous systemic lupus erythematosus: an unusual clinical course and detectable circulating autoantibodies to the epidermolysis bullosa acquisita antigen. , 1986, Journal of the American Academy of Dermatology.

[39]  L. Diaz,et al.  Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting. , 1985, Journal of immunology.

[40]  D. Woodley,et al.  Evidence that anti-basement membrane zone antibodies in bullous eruption of systemic lupus erythematosus recognize epidermolysis bullosa acquisita autoantigen. , 1985, The Journal of investigative dermatology.

[41]  P. Ihrke,et al.  Bullous pemphigoid in a dog: treatment with six-mercaptopurine. , 1984, Journal of the American Veterinary Medical Association.

[42]  D. Woodley,et al.  Identification of the skin basement-membrane autoantigen in epidermolysis bullosa acquisita. , 1984, The New England journal of medicine.

[43]  K. A. Brown,et al.  Diagnosis of autoimmune skin disease in the dog: correlation between histopathologic, direct immunofluorescent and clinical findings. , 1983, Veterinary immunology and immunopathology.

[44]  R. Lewis,et al.  Linear IgA dermatoses in the dog: bullous pemphigoid, discoid lupus erythematosus and a subcorneal pustular dermatitis. , 1982, The Cornell veterinarian.

[45]  R. Briggaman,et al.  Epidermolysis bullosa acquisita presenting as an inflammatory bullous disease. , 1982, Journal of the American Academy of Dermatology.

[46]  Fadok Va,et al.  Thrombocytopenia and hemorrhage associated with gold salt therapy for bullous pemphigoid in a dog. , 1982 .

[47]  R. Lewis,et al.  Observations of the immunopathology and therapy of canine pemphigus and pemphigoid. , 1982, Journal of the American Veterinary Medical Association.

[48]  R. Ochoa,et al.  Bullous pemphigoid refractory to recommended dosage of prednisolone in a dog. , 1981, Journal of the American Veterinary Medical Association.

[49]  E. Shevach,et al.  Characterization of bullous pemphigoid antigen: A unique basement membrane protein of stratified squamous epithelia , 1981, Cell.

[50]  E. Beutner,et al.  Basement zone antibodies in bullous pemphigoid. , 1967, JAMA.