Organization of the thalamo-cortical connexions to the frontal lobe in the rhesus monkey

SummaryIn 25 rhesus monkeys horseradish peroxidase was injected in different parts of the frontal cortex. The retrogradely labelled thalamic neurons formed longitudinal bands, some of which crossed the internal medullary lamina, and extended from one thalamic nucleus into another. On the basis of these findings the frontal cortex was subdivided into seven transverse cortical strips which receive afferents from seven longitudinal bands of thalamic neurons. The most rostral transverse strip receives afferents from the most medial thalamic band which is oriented vertically and extends through the most medial part of the MD into the medial pulvinar. Progressively more caudally located transverse strips receive afferents from progressively more laterally located thalamic bands which in part are situated in the VL and show an increasing tilt towards the horizontal. Moreover, those parts of the various bands which are situated along the dorsal and lateral margin of the thalamus project to the medial portions of the transverse cortical strips, i.e. along the medial margin of the frontal lobe, while the other parts situated ventromedially in the thalamus project to the lateral portions of these strips, i.e. along the lateral margin of the frontal lobe.These data provide an alternative view of the organization of the thalamus and suggest that this structure contains a matrix of longitudinal cell columns which in some cases extend across specific nuclear borders and may represent the basic thalamic building blocks in respect to the thalamo-cortical connexions.

[1]  L. Benevento,et al.  Projections of the medial pulvinar to orbital cortex and frontal eye fields in the rhesus monkey (Macaca mulatta) , 1975, Experimental Neurology.

[2]  H. Ku¨nzle.  Thalamic projections from the precentral motor cortex inMacaca fascicularis , 1976, Brain Research.

[3]  L. Kruger,et al.  A behavioral study of the functions of the rolandic cortex in the monkey , 1958, The Journal of comparative neurology.

[4]  J. Lavail,et al.  Retrograde Axonal Transport in the Central Nervous System , 1972, Science.

[5]  H. Künzle.  Thalamic projections from the precentral motor cortex in Macaca fascicularis. , 1976, Brain research.

[6]  J. Petras.  SOME EFFERENT CONNECTIONS OF THE MOTOR AND SOMATOSENSORY CORTEX OF SIMIAN PRIMATES AND FELID, CANID AND PROCYONID CARNIVORES , 1969 .

[7]  J. Lund,et al.  Retrograde axonal transport of horseradish peroxidase by ganglion cells of the albino rat retina. , 1974, Brain research.

[8]  M. Karnovsky,et al.  THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE , 1966, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[9]  Walker Ae.  The thalamus of the chimpanzee: IV. Thalamic projections to the cerebral cortex. , 1938 .

[10]  T. Powell,et al.  Connexions of the somatic sensory cortex of the rhesus monkey. II. Contralateral cortical connexions. , 1969, Brain : a journal of neurology.

[11]  H. Kuypers,et al.  Retrograde axonal transport of horseradish peroxidase from spinal cord to brain stem cell groups in the cat , 1975, Neuroscience Letters.

[12]  H. Kuypers,et al.  Retrograde axonal transport of horseradish peroxidase in rats forebrain. , 1974, Brain research.

[13]  K. Akert,et al.  Insular and opercular cortex and its thalamic projection in Macaca mulatta. , 1963, Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie.

[14]  G. Bonin,et al.  The neocortex of Macaca mulatta , 1947 .

[15]  K. Kristensson,et al.  Retrograde axonal transport of protein. , 1971, Brain research.

[16]  T. J. Tobias,et al.  Afferents to prefrontal cortex from the thalamic mediodorsal nucleus in the rhesus monkey , 1975, Brain Research.

[17]  D. Tanaka.  Effects of selective prefrontal decortication on escape behavior in the monkey. , 1973, Brain research.

[18]  W. Mehler.  Further notes on the centre median nucleus of Luys , 1965 .

[19]  E. G. Jones,et al.  Possible determinants of the degree of retrograde neuronal labeling with horseradish peroxidase , 1975, Brain Research.

[20]  W. Nauta,et al.  Neural associations of the amygdaloid complex in the monkey. , 1962, Brain : a journal of neurology.

[21]  K. Kristensson,et al.  Retrograde transport of horseradish peroxidase in transected axons. 1. Time relationships between transport and induction of chromatolysis. , 1974, Brain research.

[22]  E. Jones,et al.  Retrograde axonal transport and the demonstration of non‐specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey , 1974, The Journal of comparative neurology.

[23]  K. Chow,et al.  A retrograde cell degeneration study of the cortical projection field of the pulvinar in the monkey , 1950, The Journal of comparative neurology.

[24]  W. Freeman,et al.  Retrograde degeneration of the thalamus following prefrontal lobotomy , 1947, The Journal of comparative neurology.

[25]  J. Trojanowski,et al.  Medial pulvinar afferents to frontal eye fields in rhesus monkey demonstrated by horseradish peroxidase. , 1974, Brain research.

[26]  J. Lund,et al.  Monkey retinal ganglion cells: Morphometric analysis and tracing of axonal projections, with a consideration of the peroxidase technique , 1975, The Journal of comparative neurology.

[27]  A. Brodal,et al.  MODIFICATION OF GUDDEN METHOD FOR STUDY OF CEREBRAL LOCALIZATION , 1940 .

[28]  J. Olszewski.  The Thalamus of the Macaca Mulatta: An Atlas for Use with the Stereotaxic Instrument , 1952 .

[29]  T P POWELL,et al.  The cytoarchitecture of the postcentral gyrus of the monkey Macaca mulatta. , 1959, Bulletin of the Johns Hopkins Hospital.

[30]  Duke Tanaka,et al.  Thalamic projections of the dorsomedial prefrontal cortex in the rhesus monkey (Macaca mulatta) , 1976, Brain Research.

[31]  H. Burton,et al.  The posterior thalamic region and its cortical projection in new world and old world monkeys , 1976, The Journal of comparative neurology.

[32]  M. Murray.  Degeneration of some intralaminar thalamic nuclei after cortical removals in the cat , 1966, The Journal of comparative neurology.

[33]  A. Scheibel,et al.  The organization of the ventral anterior nucleus of the thalamus. A Golgi study. , 1966, Brain research.

[34]  P. Carmel.  Efferent projections of the ventral anterior nucleus of the thalamus in the monkey. , 1970, The American journal of anatomy.

[35]  A. Walker.  The thalamus of the chimpanzee: IV. Thalamic projections to the cerebral cortex. , 1938, Journal of anatomy.

[36]  J. Astruc.  Corticofugal connections of area 8 (frontal eye field) in Macaca mulatta. , 1971, Brain research.

[37]  A. Scheibel,et al.  Structural organization of nonspecific thalamic nuclei and their projection toward cortex. , 1967, Brain research.

[38]  T. Mclardy,et al.  Prefrontal leucotomy; a neuro-anatomical report. , 1947, Brain : a journal of neurology.

[39]  O. Smith,et al.  Subcortical projections of the prefrontal lobe of the monkey , 1964, The Journal of comparative neurology.

[40]  P. Strick.  Anatomical analysis of ventrolateral thalamic input to primate motor cortex. , 1976, Journal of neurophysiology.

[41]  R. L. Crouch.  Nuclear Configuration of Thalamus of Macacus Rhesus , 1933 .

[42]  S. Sakai.  Some Observations on the Cortico-thalamic Fiber Connections in the Monkey , 1967 .

[43]  A. Walker.  The primate thalamus , 1940 .

[44]  N. Mizuno,et al.  Thalamic afferents to the rostral portions of the middle suprasylvian gyrus in the cat , 1975, Experimental Neurology.

[45]  M. J. Showers.  Correlation of medial thalamic nuclear activity with cortical and subcortical neuronal arcs , 1958, The Journal of comparative neurology.

[46]  Mountcastle Vb,et al.  The cytoarchitecture of the postcentral gyrus of the monkey Macaca mulatta. , 1959 .

[47]  T. Powell,et al.  Connexions of the somatic sensory cortex of the rhesus monkey. 3. Thalamic connexions. , 1970, Brain : a journal of neurology.

[48]  W. E. Clark,et al.  The Thalamic Connections of the Parietal and Frontal Lobes of the Brain in the Monkey , 1935 .

[49]  K. Pribram,et al.  Cortical projection of the thalamic ventrolateral nuclear group in monkeys , 1956, The Journal of comparative neurology.

[50]  T. Powell.  Residual neurons in the human thalamus following hemidecortication. , 1952, Brain : a journal of neurology.

[51]  C. Woolsey,et al.  Patterns of localization in precentral and "supplementary" motor areas and their relation to the concept of a premotor area. , 1952, Research publications - Association for Research in Nervous and Mental Disease.

[52]  D. Simmons,et al.  Some connections of the posterior thalamus in monkey , 1976, Experimental Neurology.

[53]  J. Devito.  Projections from the cerebral cortex to intralaminar nuclei in monkey , 1969, The Journal of comparative neurology.

[54]  K. Kristensson.  Retrograde axonal transport of horseradish peroxidase , 1977, Acta Neuropathologica.