Burden of thyroid cancer in North Africa and Middle East 1990–2019

Background Thyroid cancer is the leading cause of mortality and morbidity among cancers of the endocrine system. We aimed to describe the trends of thyroid cancer burden in North Africa and Middle East for 1990–2019. Methods Data on burden of thyroid cancer in North Africa and Middle East from 1990 to 2019 were obtained from the Global Burden of Disease (GBD) Study 2019. Decomposition analysis was used to estimate the effects of population growth, aging, and change in incident numbers on overall change of thyroid cancer incidence. Also, we used the comparative risk assessment framework of GBD to determine the burden of thyroid cancer attributable to a high body mass index (BMI). Results In 2019, the age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of thyroid cancer were 3.5 (2.9–4) and 0.5 (0.5–0.7) per 100,000, respectively. The highest age-standardized incidence, deaths, and disability-adjusted life year (DALY) rate were in Lebanon, Afghanistan, and United Arab Emirates, respectively. The ASIR of thyroid cancer in region was about 2.5 times higher among women, which had a positive association with increasing age. In 2019, the age-standardized deaths attributable to a high BMI was 16.7% of all deaths due to thyroid cancer. In 1990–2019, the overall change in thyroid cancer incident cases was a 396% increase which was mostly driven by the increase in disease-specific incidence rate (256.8%). Conclusions Women, the elderly above about 60 years old, and countries with a higher sociodemographic index showed higher incidence rates of thyroid cancer. Regarding our findings, it is recommended to establish preventive plans by modification in life style like weight reduction programs.

[1]  Tong Deng,et al.  Global burden of thyroid cancer and its attributable risk factors in 204 countries and territories from 1990 to 2019 , 2021, Thoracic cancer.

[2]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[3]  Dan J Stein,et al.  Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 , 2020, Lancet.

[4]  Eun Sug Park,et al.  Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 , 2020, Lancet.

[5]  Jianhong Wu,et al.  The global burden of disease attributable to high body mass index in 195 countries and territories, 1990–2017: An analysis of the Global Burden of Disease Study , 2020, PLoS medicine.

[6]  B. Al-Sharafi,et al.  Thyroid cancer among patients with thyroid nodules in Yemen: a three-year retrospective study in a tertiary center and a specialty clinic , 2020, Thyroid Research.

[7]  Z. Dai,et al.  Global Burden of Thyroid Cancer From 1990 to 2017 , 2020, JAMA network open.

[8]  J. Al-Lawati,et al.  Increasing Thyroid Cancer Incidence in Oman: A Joinpoint Trend Analysis , 2020, Oman medical journal.

[9]  F. Azizi,et al.  Metabolic health in the Middle East and north Africa. , 2019, The lancet. Diabetes & endocrinology.

[10]  Zhiyan Liu,et al.  The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives , 2018, Pathology international.

[11]  Mohammad Hosein Farzaei,et al.  Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 , 2018, Lancet.

[12]  A. Jemal,et al.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries , 2018, CA: a cancer journal for clinicians.

[13]  Ronan A Lyons,et al.  Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016 , 2018, The Lancet.

[14]  R. Malekzadeh,et al.  Burden of obesity in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study , 2017, International Journal of Public Health.

[15]  T. H. Nguyen,et al.  Burden of cancer in the Eastern Mediterranean Region, 2005–2015: findings from the Global Burden of Disease 2015 Study , 2017, International Journal of Public Health.

[16]  Joshua A. Salomon,et al.  Health Effects of Overweight and Obesity in 195 Countries over 25 Years. , 2017, The New England journal of medicine.

[17]  B. Alshehri.  Descriptive Epidemiological Analysis of Thyroid Cancer in the Saudi Population (2001-2013) , 2017, Asian Pacific journal of cancer prevention : APJCP.

[18]  Alan D. Lopez,et al.  Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study , 2017, JAMA oncology.

[19]  Huihui Wang,et al.  Benchmarking Health Systems in Middle Eastern and North African Countries , 2017, Health systems and reform.

[20]  T. Vos,et al.  Guidelines for Accurate and Transparent Health Estimates Reporting: the GATHER statement , 2016, PLoS medicine.

[21]  J. Sosa,et al.  The changing incidence of thyroid cancer , 2016, Nature Reviews Endocrinology.

[22]  S. Roman,et al.  Exploring the Relationship Between Patient Age and Cancer-Specific Survival in Papillary Thyroid Cancer: Rethinking Current Staging Systems. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[23]  F. Azizi,et al.  Thyroid Cancer Epidemiology in Iran: a Time Trend Study. , 2016, Asian Pacific journal of cancer prevention : APJCP.

[24]  Elizabeth E Ward,et al.  Anthropometric Factors and Thyroid Cancer Risk by Histological Subtype: Pooled Analysis of 22 Prospective Studies. , 2016, Thyroid : official journal of the American Thyroid Association.

[25]  P. Vigneri,et al.  The changing epidemiology of thyroid cancer: why is incidence increasing? , 2015, Current opinion in oncology.

[26]  F. Frasca,et al.  Worldwide Increasing Incidence of Thyroid Cancer: Update on Epidemiology and Risk Factors , 2013, Journal of cancer epidemiology.

[27]  K. Schwartz,et al.  Comparison of Exposures Among Arab American and Non-Hispanic White Female Thyroid Cancer Cases in Metropolitan Detroit , 2011, Journal of Immigrant and Minority Health.

[28]  S. Wiseman,et al.  Gender differences in thyroid cancer: a critical review , 2011, Expert review of endocrinology & metabolism.

[29]  Nathaniel Rothman,et al.  International patterns and trends in thyroid cancer incidence, 1973–2002 , 2009, Cancer Causes & Control.

[30]  Z. Qureshi,et al.  Rebuilding the health care system in Afghanistan: an overview of primary care and emergency services , 2009, International journal of emergency medicine.

[31]  Z. Jehan,et al.  Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population. , 2008, The Journal of clinical endocrinology and metabolism.

[32]  Alan D. Lopez,et al.  Comparative quantification of health risks: Conceptual framework and methodological issues , 2003, Population health metrics.

[33]  W. Maziak,et al.  Neoplastic diseases in Aleppo, Syria , 2002, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[34]  Alan D. Lopez,et al.  Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study , 1997, The Lancet.

[35]  M. Ghoncheh.  INCIDENCE, MORTALITY, AND RISK FACTORS OF THYROID CANCER IN THE WORLD: A REVIEW , 2018 .

[36]  Gretchen A. Stevens,et al.  Global burden of cancer attributable to high body-mass index in 2012: a population-based study. , 2015, The Lancet. Oncology.