An acetyl-L-carnitine switch on mitochondrial dysfunction and rescue in the metabolomics study on aluminum oxide nanoparticles

[1]  T. Nurkiewicz,et al.  Microvascular and mitochondrial dysfunction in the female F1 generation after gestational TiO2 nanoparticle exposure , 2015, Nanotoxicology.

[2]  R. Moreau,et al.  Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid. , 2015, The Journal of nutritional biochemistry.

[3]  Amalie Thit,et al.  Toxic mechanisms of copper oxide nanoparticles in epithelial kidney cells. , 2015, Toxicology in vitro : an international journal published in association with BIBRA.

[4]  Rachel Cavill,et al.  Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells , 2015, Nanotoxicology.

[5]  R. Crystal,et al.  Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. , 2015, The American review of respiratory disease.

[6]  V. Castranova,et al.  Effects of nickel-oxide nanoparticle pre-exposure dispersion status on bioactivity in the mouse lung , 2015, Nanotoxicology.

[7]  Z. Cai,et al.  Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. , 2015, Journal of hazardous materials.

[8]  J. Armengaud,et al.  High-throughput, quantitative assessment of the effects of low-dose silica nanoparticles on lung cells: grasping complex toxicity with a great depth of field , 2015, BMC Genomics.

[9]  Qingyue Wang,et al.  Comparison of cellular toxicity caused by ambient ultrafine particles and engineered metal oxide nanoparticles , 2015, Particle and Fibre Toxicology.

[10]  W. Hauswirth,et al.  Complex I subunit gene therapy with NDUFA6 ameliorates neurodegeneration in EAE. , 2015, Investigative ophthalmology & visual science.

[11]  Yan Huang,et al.  Toxicity of silver nanoparticles to human dermal fibroblasts on microRNA level. , 2014, Journal of biomedical nanotechnology.

[12]  S. Xiong,et al.  Mitochondria-mediated apoptosis in mammals , 2014, Protein & Cell.

[13]  Yankai Xia,et al.  Metabolomic profiles delineate the potential role of glycine in gold nanorod-induced disruption of mitochondria and blood-testis barrier factors in TM-4 cells. , 2014, Nanoscale.

[14]  Amy K Madl,et al.  Nanoparticles, lung injury, and the role of oxidant stress. , 2014, Annual review of physiology.

[15]  S. French,et al.  Acetyl-L-carnitine and lipoic acid improve mitochondrial abnormalities and serum levels of liver enzymes in a mouse model of nonalcoholic fatty liver disease. , 2013, Nutrition research.

[16]  Liying Wang,et al.  Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity , 2013, BioMed research international.

[17]  J. Musarrat,et al.  Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells , 2013, PloS one.

[18]  Ji-Eun Kim,et al.  Zinc oxide nanoparticle induced autophagic cell death and mitochondrial damage via reactive oxygen species generation. , 2013, Toxicology in vitro : an international journal published in association with BIBRA.

[19]  Alexander D. MacKerell,et al.  The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak , 2013, Molecular Cancer.

[20]  Xiang Wang,et al.  Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. , 2013, Accounts of chemical research.

[21]  Herman Autrup,et al.  Global gene expression profiling of human lung epithelial cells after exposure to nanosilver. , 2012, Toxicological sciences : an official journal of the Society of Toxicology.

[22]  Sangdun Choi,et al.  Analysis of changes in gene expression and metabolic profiles induced by silica-coated magnetic nanoparticles. , 2012, ACS nano.

[23]  M. Malaguarnera.  Carnitine derivatives: clinical usefulness , 2012, Current opinion in gastroenterology.

[24]  M. Ahamed,et al.  ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress. , 2011, Nanomedicine : nanotechnology, biology, and medicine.

[25]  N. Hanagata,et al.  Molecular responses of human lung epithelial cells to the toxicity of copper oxide nanoparticles inferred from whole genome expression analysis. , 2011, ACS nano.

[26]  P. Pinton,et al.  Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging , 2011, Journal of signal transduction.

[27]  P. Convertini,et al.  The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology. , 2011, Molecular aspects of medicine.

[28]  R. Thirukumaran,et al.  Acetyl-l-carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats , 2011, Journal of Physiology and Biochemistry.

[29]  S. Ryter,et al.  Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. , 2011, Nature immunology.

[30]  Iseult Lynch,et al.  Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices , 2011, Nanotoxicology.

[31]  L. Galluzzi,et al.  Targeting mitochondria for cancer therapy , 2010, Nature Reviews Drug Discovery.

[32]  Alexander Sasha Rabchevsky,et al.  Acetyl‐l‐carnitine ameliorates mitochondrial dysfunction following contusion spinal cord injury , 2010, Journal of neurochemistry.

[33]  L. Zolla,et al.  Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria. , 2009, Biochimica et biophysica acta.

[34]  B. Ames,et al.  Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-Lipoic Acid and Acetyl-l-carnitine , 2009, Neurochemical Research.

[35]  M. Hande,et al.  Cytotoxicity and genotoxicity of silver nanoparticles in human cells. , 2009, ACS nano.

[36]  P. Baron,et al.  Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[37]  F. Collins,et al.  Transforming Environmental Health Protection , 2008, Science.

[38]  M. El-Hafidi,et al.  Analysis of age-associated changes in mitochondrial free radical generation by rat testis , 2007, Molecular and Cellular Biochemistry.

[39]  C. Ghelardini,et al.  Protective effect of acetyl‐l‐carnitine on the apoptotic pathway of peripheral neuropathy , 2007, The European journal of neuroscience.

[40]  H. Hoppeler,et al.  Acetyl-L-carnitine feeding to unloaded rats triggers in soleus muscle the coordinated expression of genes involved in mitochondrial biogenesis. , 2006, Biochimica et biophysica acta.

[41]  B. Van Houten,et al.  Role of mitochondrial DNA in toxic responses to oxidative stress. , 2006, DNA repair.

[42]  T. Shea,et al.  Acetyl-l-Carnitine Protects Against Amyloid-Beta Neurotoxicity: Roles of Oxidative Buffering and ATP Levels , 2002, Neurochemical Research.

[43]  Yigong Shi,et al.  A structural view of mitochondria-mediated apoptosis , 2001, Nature Structural Biology.

[44]  M B Schenker,et al.  Distribution of particulate matter and tissue remodeling in the human lung. , 2000, Environmental health perspectives.

[45]  J. Pettegrew,et al.  Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression , 2000, Molecular Psychiatry.

[46]  C. Manetti,et al.  Entry of [(1,2-13C2)acetyl]-L-carnitine in liver tricarboxylic acid cycle and lipogenesis: a study by 13C NMR spectroscopy in conscious, freely moving rats. , 1999, European journal of biochemistry.

[47]  A. Halayko,et al.  Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. , 2010, American journal of physiology. Endocrinology and metabolism.

[48]  T. Sandström,et al.  Adverse cardiovascular effects of air pollution , 2009, Nature Clinical Practice Cardiovascular Medicine.

[49]  A. Strasser,et al.  The BCL-2 protein family: opposing activities that mediate cell death , 2008, Nature Reviews Molecular Cell Biology.