The Impact of Visual Field Clusters on Performance-based Measures and Vision-Related Quality of Life in Patients With Glaucoma.

PURPOSE To investigate how visual field (VF) clusters affect performance-based measures of the ability to perform activities of daily living and subjective measures of vision-related quality of life (QoL) in patients with glaucoma. DESIGN Prospective, cross-sectional study. METHODS setting: Institutional - Wills Eye Hospital. STUDY POPULATION 322 eyes of 161 patients with moderate-stage glaucoma. OBSERVATION VF tests were conducted using the Humphrey 24-2 Swedish Interactive Thresholding Algorithm standard perimeter. The VFs of each patient were divided into 5 clusters: nasal, temporal, central, paracentral, and peripheral. The score for each cluster was the averaged total deviation scores of all tested points within the cluster. Each cluster score was correlated with performance-based measures of visual function and subjective assessment of vision-related QoL. MAIN OUTCOME MEASURES The Compressed Assessment of Ability Related to Vision, the National Eye Institute Visual Functioning Questionnaire 25 (NEI VFQ-25), and the Modified Glaucoma Symptom Scale. RESULTS The central VF cluster in the better eye was positively correlated with all Compressed Assessment of Ability Related to Vision (performance-based measure) subscales. The strongest correlation for the better eye was between the central VF cluster and total Compressed Assessment of Ability Related to Vision score (0.39, P < .001). The inferior VF hemisphere in both eyes was positively correlated with most Compressed Assessment of Ability Related to Vision subscales. Central VF clusters in the better eye were positively correlated with a majority of the NEI VFQ-25 subscales. There were no significant correlations between VF clusters and Modified Glaucoma Symptom Scale subscales. CONCLUSIONS Scores of central VF defects in the better eye and inferior hemisphere defects in both eyes were positively correlated with performance-based measures of the ability to perform activities of daily living. Glaucoma patients with central defects in the better eye were more likely to have reduced scores on assessments of vision-related QoL.

[1]  Hiroshi Murata,et al.  Impact of better and worse eye damage on quality of life in advanced glaucoma , 2014, Scientific Reports.

[2]  E. Boer,et al.  Longitudinal changes in quality of life and rates of progressive visual field loss in glaucoma patients. , 2015, Ophthalmology.

[3]  G. Spaeth,et al.  Relationships in Glaucoma Patients Between Standard Vision Tests, Quality of Life, and Ability to Perform Daily Activities , 2010, Ophthalmic epidemiology.

[4]  G. Spaeth,et al.  Visual field staging systems in glaucoma and the activities of daily living. , 2012, American journal of ophthalmology.

[5]  J. Severens,et al.  The relationship between visual field loss in glaucoma and health-related quality-of-life , 2010, Eye.

[6]  Chao-Yu Guo,et al.  Patient-reported vision-related quality of life differences between superior and inferior hemifield visual field defects in primary open-angle glaucoma. , 2015, JAMA ophthalmology.

[7]  Y. Aoyama,et al.  Identifying Areas of the Visual Field Important for Quality of Life in Patients with Glaucoma , 2013, PloS one.

[8]  Haruki Abe,et al.  Assessment of the Vision-specific Quality of Life Using Clustered Visual Field in Glaucoma Patients , 2014, Journal of glaucoma.

[9]  G. Spaeth,et al.  Evaluation of quality of life for patients with glaucoma. , 2006, American journal of ophthalmology.

[10]  R. Ritch,et al.  The Glaucoma Symptom Scale. A brief index of glaucoma-specific symptoms. , 1998, Archives of ophthalmology.

[11]  R. Murphy,et al.  A prospective, longitudinal, observational cohort study examining how glaucoma affects quality of life and visually-related function over 4 years: design and methodology , 2015, BMC Ophthalmology.

[12]  M. Araie,et al.  The relationship between visual disability and visual field in patients with glaucoma. , 2003, Ophthalmology.

[13]  G. Spaeth,et al.  A clinical method to assess the effect of visual loss on the ability to perform activities of daily living , 2012, British Journal of Ophthalmology.

[14]  N. Logothetis,et al.  What is rivalling during binocular rivalry , 1996 .

[15]  Beatriz Munoz,et al.  Glaucoma and reading speed: the Salisbury Eye Evaluation project. , 2009, Archives of ophthalmology.

[16]  F. Medeiros,et al.  Association between rates of binocular visual field loss and vision-related quality of life in patients with glaucoma. , 2013, JAMA ophthalmology.

[17]  R. Sihota,et al.  Effect of glaucoma on the quality of life of young patients. , 2011, Investigative ophthalmology & visual science.

[18]  R. Hays,et al.  Development of the 25-item National Eye Institute Visual Function Questionnaire. , 2001 .

[19]  George L Spaeth,et al.  Reliability of the disk damage likelihood scale. , 2003, American journal of ophthalmology.

[20]  J. Henderer,et al.  Disc damage likelihood scale , 2006, British Journal of Ophthalmology.

[21]  G. Spaeth,et al.  The assessment of disability related to vision performance-based measure in diabetic retinopathy. , 2010, American journal of ophthalmology.

[22]  H. Quigley,et al.  The number of people with glaucoma worldwide in 2010 and 2020 , 2006, British Journal of Ophthalmology.

[23]  G. Spaeth,et al.  The disc damage likelihood scale: reproducibility of a new method of estimating the amount of optic nerve damage caused by glaucoma. , 2002, Transactions of the American Ophthalmological Society.

[24]  L. Scudeller,et al.  Ocular surface disease and glaucoma: how to evaluate impact on quality of life. , 2013, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[25]  B. Munoz,et al.  Glaucoma and quality of life: the Salisbury Eye Evaluation. , 2008, Ophthalmology.

[26]  I. Goldberg,et al.  Depression and Quality of Life in Patients With Glaucoma: A Cross-sectional Analysis Using the Geriatric Depression Scale-15, Assessment of Function Related to Vision, and the Glaucoma Quality of Life-15 , 2008, Journal of glaucoma.

[27]  ASSESSING AGE-RELATED MACULAR DEGENERATION WITH THE ADREV PERFORMANCE-BASED MEASURE , 2009, Retina.

[28]  J. Wood,et al.  Inferior visual field reductions are associated with poorer functional status among older adults with glaucoma , 2011, Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians.

[29]  G. Spaeth,et al.  Performance-based measures of visual function. , 2010, Survey of ophthalmology.

[30]  T. Wong,et al.  Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. , 2014, Ophthalmology.

[31]  Y. Wang,et al.  Evaluating a New Disc Staging Scale for Glaucomatous Damage: The Ability to Detect Change over Time , 2009, European journal of ophthalmology.

[32]  H. Quigley.  Number of people with glaucoma worldwide. , 1996, The British journal of ophthalmology.

[33]  William J. Cardarelli,et al.  Managed care implications of age-related ocular conditions. , 2013, The American journal of managed care.