Antibacterial activity of new benzylbenzimidazole complexes against Gram-positive (+ve) and-negative (-ve) bacterial species isolated from surgical wounds of Iraqi patients

Antibiotics or antibacterial are a type of antimicrobial drug. Used to treat infections caused by germs (bacteria and certain parasites).They may either kill or inhibit the growth of those organism. Several types of antibiotics also possess antiprotozoal activity. In each year all over the world, millions of patients become infected with bacteria that are resistant to antibiotics and thousands of people die each year as a direct result of these infections. Prompting the researchers to find new antibiotics to confrontation like this challenge. So for the first time in this project we evaluate the effect of New complexes of VO +2 , Co +2 , Ni +2 , Cu +2 and Ag + with 1-benzylbenzimidazole (Bbz) were synthesized by reaction of the ligand with suitable metal sources against several selected human pathogenic bacterial species for both Gram-positive ( + v e) and negative ( v e) bacteria isolated from surgical wounds. By using of disk diffusion technique our findings demonstrated that New complexes of VO +2 , Co +2 , Ni +2 , Cu +2 and Ag + with 1-benzylbenzimidazole (Bbz) showed inhibition for both Gram-positive ( + v e) and negative ( v e) bacteria but varying effects of each compound.

[1]  Cheng‐He Zhou,et al.  Recent developments in azole compounds as antibacterial and antifungal agents. , 2013, Current topics in medicinal chemistry.

[2]  N. Demirbas,et al.  Design, synthesis and antimicrobial activities of some azole derivatives. , 2013, Acta poloniae pharmaceutica.

[3]  M. Whiteley,et al.  A Bilayer-Couple Model of Bacterial Outer Membrane Vesicle Biogenesis , 2012, mBio.

[4]  M. Kuehn,et al.  Biological functions and biogenesis of secreted bacterial outer membrane vesicles. , 2010, Annual review of microbiology.

[5]  M. Kuehn,et al.  Virulence and Immunomodulatory Roles of Bacterial Outer Membrane Vesicles , 2010, Microbiology and Molecular Biology Reviews.

[6]  S. Yıldız,et al.  Synthesis and potent antimicrobial activity of some novel methyl or ethyl 1H-benzimidazole-5-carboxylates derivatives carrying amide or amidine groups. , 2005, Bioorganic & medicinal chemistry.

[7]  C. Karunakaran,et al.  Synthesis, X-ray crystal structure, antimicrobial activity and photodynamic effects of some thiabendazole complexes. , 2004, Journal of inorganic biochemistry.

[8]  P. Mahulikar,et al.  Studies of antimicrobial activity of N-alkyl and N-acyl 2-(4-thiazolyl)-1H-benzimidazoles. , 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[9]  T. Beveridge Structures of Gram-Negative Cell Walls and Their Derived Membrane Vesicles , 1999, Journal of bacteriology.

[10]  Richard J. Sundberg,et al.  Interactions of histidine and other imidazole derivatives with transition metal ions in chemical and biological systems , 1974 .

[11]  J. Costerton,et al.  Structure and function of the cell envelope of gram-negative bacteria , 1974, Bacteriological reviews.

[12]  J. Costerton,et al.  Structure and function of the cell envelope of gram-negative bacteria , 1974, Bacteriological reviews.

[13]  M. Palaniandavar,et al.  Synthesis, structure, spectra and redox chemistry of iron(III) complexes of tridentate pyridyl and benzimidazolyl ligands , 1996 .

[14]  J. D. Crane,et al.  Tripodal benzimidazolate complexes of tricarbonylmolybdenum(0) and of iron(III) , 1990 .