Do B-cell chronic lymphocytic leukemia patients with Ig VH3-21 genes constitute a new subset of chronic lymphocytic leukemia?

With interest we read the report of Tobin et al[1][1] describing a new subset of B-cell chronic lymphocytic leukemia (B-CLL). After mutation analysis of rearranged immunoglobulin variable heavy chain (IgVH) genes, they observed that B-CLL patients with somatically mutated VH3-21 genes have an

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