论文信息 - Extracts of muscle biopsies from patients with spinal muscular atrophies inhibit neurite outgrowth from spinal neurons

Extracts of muscle biopsies from patients with spinal muscular atrophies inhibit neurite outgrowth from spinal neurons

Preparations derived from embryonic and neonatal chick muscle enhance neurite outgrowth when added to cultures of embryonic chick spinal neurons. In the presence of soluble extracts of biopsied muscle from 15 of 20 patients with spinal muscular atrophy (SMA), the in vitro neurite-promoting activity of neonatal chick muscle was inhibited. There was no comparable inhibition using extracts from 20 age-matched pathologic or morphologically normal controls. The neurite-promoting activity in media conditioned by embryonic myotubes was not inhibited by extracts of the SMA group.

[1] M. Gurney,et al. Inhibition of terminal axonal sprouting by serum from patients with amyotrophic lateral sclerosis. , 1984, The New England journal of medicine.

[2] C. Henderson,et al. Neurite-promoting activities for embryonic spinal neurons and their developmental changes in the chick. , 1984, Developmental biology.

[3] D. K. Berg. New neuronal growth factors. , 1984, Annual review of neuroscience.

[4] J. Changeux,et al. Denervation increases a neurite-promoting activity in extracts of skeletal muscle , 1983, Nature.

[5] S H Appel,et al. A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and alzheimer disease , 1981, Annals of neurology.

[6] C. Henderson,et al. Neurite outgrowth from embryonic chicken spinal neurons is promoted by media conditioned by muscle cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[7] P. Tsairis. Muscle Biopsy: A Modern Approach , 1974 .

[8] A. Emery. The nosology of the spinal muscular atrophies. , 1971, Journal of medical genetics.