ICF syndrome mutations cause a broad spectrum of biochemical defects in DNMT3B-mediated de novo DNA methylation.

[1]  J. Licht,et al.  DNMT3A mutations in acute myeloid leukemia , 2011, Nature Genetics.

[2]  Yong-mei Zhu,et al.  Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia , 2011, Nature Genetics.

[3]  Li Ding,et al.  Recurrent DNMT3A Mutations in Patients with Myelodysplastic Syndromes , 2011, Leukemia.

[4]  K. Robertson,et al.  Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants , 2011, Nucleic acids research.

[5]  Michael Weber,et al.  Targets and dynamics of promoter DNA methylation during early mouse development , 2010, Nature Genetics.

[6]  F. Chédin,et al.  DNMT3L Modulates Significant and Distinct Flanking Sequence Preference for DNA Methylation by DNMT3A and DNMT3B In Vivo , 2010, PLoS genetics.

[7]  N. Reich,et al.  Identification of a second DNA binding site in human DNA methyltransferase 3A by substrate inhibition and domain deletion. , 2010, Archives of biochemistry and biophysics.

[8]  E. Li,et al.  Genetic evidence for Dnmt3a‐dependent imprinting during oocyte growth obtained by conditional knockout with Zp3‐Cre and complete exclusion of Dnmt3b by chimera formation , 2010, Genes to cells : devoted to molecular & cellular mechanisms.

[9]  Chia-Lin Wei,et al.  Dynamic changes in the human methylome during differentiation. , 2010, Genome research.

[10]  Lee E. Edsall,et al.  Human DNA methylomes at base resolution show widespread epigenomic differences , 2009, Nature.

[11]  Michael Weber,et al.  Dynamic regulation of DNA methylation during mammalian development. , 2009, Epigenomics.

[12]  D. Schübeler,et al.  Genetics and epigenetics: stability and plasticity during cellular differentiation. , 2009, Trends in genetics : TIG.

[13]  R. Reinhardt,et al.  Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L , 2008, Nucleic acids research.

[14]  Michael B. Stadler,et al.  Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. , 2008, Molecular cell.

[15]  R. Blumenthal,et al.  Mammalian DNA methyltransferases: a structural perspective. , 2008, Structure.

[16]  G. Gimelli,et al.  Clinical spectrum of immunodeficiency, centromeric instability and facial dysmorphism (ICF syndrome) , 2007, Journal of Medical Genetics.

[17]  Xiaodong Cheng,et al.  Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation , 2007, Nature.

[18]  E. Li,et al.  DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. , 2006, Genes & development.

[19]  F. Chédin,et al.  Reconstitution and Mechanism of the Stimulation of de Novo Methylation by Human DNMT3L* , 2006, Journal of Biological Chemistry.

[20]  A. Riggs,et al.  Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. , 2006, Human molecular genetics.

[21]  E. Li,et al.  Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome , 2006, Development.

[22]  K. Robertson.  DNA methylation and human disease , 2005, Nature Reviews Genetics.

[23]  A. Riggs,et al.  Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family , 2005, Journal of cellular biochemistry.

[24]  T. Bestor,et al.  Eukaryotic cytosine methyltransferases. , 2005, Annual review of biochemistry.

[25]  Li Yu,et al.  [DNA methylation and cancer]. , 2005, Zhonghua nei ke za zhi.

[26]  T. Bestor,et al.  Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L , 2004, Nature.

[27]  E. Li,et al.  Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting , 2004, Nature.

[28]  E. Li,et al.  Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b , 2003, Molecular and Cellular Biology.

[29]  A. Jeltsch,et al.  Catalytic mechanism of DNA-(cytosine-C5)-methyltransferases revisited: covalent intermediate formation is not essential for methyl group transfer by the murine Dnmt3a enzyme. , 2003, Journal of molecular biology.

[30]  C. Murakami,et al.  Distinct enzymatic properties of recombinant mouse DNA methyltransferases Dnmt3a and Dnmt3b. , 2003, Journal of biochemistry.

[31]  M. Lieber,et al.  The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[32]  En Li,et al.  A Novel Dnmt3a Isoform Produced from an Alternative Promoter Localizes to Euchromatin and Its Expression Correlates with Activede Novo Methylation* , 2002, The Journal of Biological Chemistry.

[33]  T. Bestor,et al.  Histone modification and replacement in chromatin activation. , 2002, Genes & development.

[34]  Albert Jeltsch,et al.  Molecular Enzymology of the Catalytic Domains of the Dnmt3a and Dnmt3b DNA Methyltransferases* 210 , 2002, The Journal of Biological Chemistry.

[35]  K. Robertson,et al.  Preferential Methylation of Unmethylated DNA by Mammaliande Novo DNA Methyltransferase Dnmt3a* , 2002, The Journal of Biological Chemistry.

[36]  C. Hsieh,et al.  Murine De Novo Methyltransferase Dnmt3a Demonstrates Strand Asymmetry and Site Preference in the Methylation of DNA In Vitro , 2002, Molecular and Cellular Biology.

[37]  A. Bird.  DNA methylation patterns and epigenetic memory. , 2002, Genes & development.

[38]  T. Bestor,et al.  Dnmt3L and the Establishment of Maternal Genomic Imprints , 2001, Science.

[39]  H. Sasaki,et al.  Enzymatic properties of de novo-type mouse DNA (cytosine-5) methyltransferases. , 2001, Nucleic acids research.

[40]  T. Bestor,et al.  The DNA methyltransferases of mammals. , 2000, Human molecular genetics.

[41]  C. Wijmenga,et al.  The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[42]  C. Hsieh.  In Vivo Activity of Murine De Novo Methyltransferases, Dnmt3a and Dnmt3b , 1999, Molecular and Cellular Biology.

[43]  R J Roberts,et al.  Recombinant Human DNA (Cytosine-5) Methyltransferase , 1999, The Journal of Biological Chemistry.

[44]  N. Tommerup,et al.  Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene , 1999, Nature.

[45]  C. Papadopoulos,et al.  Nanoelectronics: Growing Y-junction carbon nanotubes , 1999, Nature.

[46]  D. Haber,et al.  DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.

[47]  R. Roberts,et al.  Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide. , 1999, Journal of molecular biology.

[48]  R. Roberts,et al.  Hhal methyltransferase flips its target base out of the DNA helix , 1994, Cell.

[49]  Richard J. Roberts,et al.  Crystal structure of the Hhal DNA methyltransferase complexed with S-adenosyl-l-methionine , 1993, Cell.

[50]  R. Roberts,et al.  The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic center. , 1993, Nucleic acids research.

[51]  M. Wyszynski,et al.  The cysteine conserved among DNA cytosine methylases is required for methyl transfer, but not for specific DNA binding. , 1993, Nucleic acids research.

[52]  V. Ingram,et al.  Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. , 1988, Journal of molecular biology.

[53]  D. Santi,et al.  Kinetic and catalytic mechanism of HhaI methyltransferase. , 1987, The Journal of biological chemistry.