Myocardial T2 quantitation in patients with iron overload at 3 Tesla

To investigate the feasibility of measuring myocardial T2 at 3 Tesla for assessment of tissue iron in thalassemia major and other iron overloaded patients.

[1]  D. Fitchett,et al.  Cardiac involvement in secondary haemochromatosis: a catheter biopsy study and analysis of myocardium. , 1980, Cardiovascular research.

[2]  J. Hennig.  Multiecho imaging sequences with low refocusing flip angles , 1988 .

[3]  C. McLaren,et al.  Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. , 1994, The New England journal of medicine.

[4]  R. Balaban,et al.  Simulation of B1 field distribution and intrinsic signal-to-noise in cardiac MRI as a function of static magnetic field. , 1997, Journal of magnetic resonance.

[5]  H. Wen,et al.  Simulation ofB1Field Distribution and Intrinsic Signal-to-Noise in Cardiac MRI as a Function of Static Magnetic Field , 1997 .

[6]  E R McVeigh,et al.  In vivo measurement of T*2 and field inhomogeneity maps in the human heart at 1.5 T , 1998, Magnetic resonance in medicine.

[7]  H. Bonkovsky,et al.  Hepatic iron concentration: noninvasive estimation by means of MR imaging techniques. , 1999, Radiology.

[8]  H. Rinneberg,et al.  Human cardiac imaging at 3 T using phased array coils , 2000, Magnetic resonance in medicine.

[9]  D N Firmin,et al.  Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. , 2001, European heart journal.

[10]  Y. Kan,et al.  Prospects for research in hematologic disorders: sickle cell disease and thalassemia. , 2001, JAMA.

[11]  T J Brady,et al.  Cardiac susceptibility artifacts arising from the heart‐lung interface , 2001, Magnetic resonance in medicine.

[12]  A. Schechter,et al.  Genetic diseases of hemoglobin: diagnostic methods for elucidating beta-thalassemia mutations. , 2001, Blood reviews.

[13]  T. S. St. Pierre,et al.  Proton transverse relaxation rate (R2) images of liver tissue; mapping local tissue iron concentrations with MRI [corrected]. , 2003, Magnetic resonance in medicine.

[14]  T. S. St. Pierre,et al.  Proton transverse relaxation rate (R2) images of iron‐loaded liver tissuepping local tissue iron concentrations with MRI , 2003 .

[15]  Robert V Mulkern,et al.  Double inversion black‐blood fast spin‐echo imaging of the human heart: A comparison between 1.5T and 3.0T , 2003, Journal of magnetic resonance imaging : JMRI.

[16]  D. Pennell,et al.  A single breath‐hold multiecho T2* cardiovascular magnetic resonance technique for diagnosis of myocardial iron overload , 2003, Journal of magnetic resonance imaging : JMRI.

[17]  Mark A Westwood,et al.  Interscanner reproducibility of cardiovascular magnetic resonance T2* measurements of tissue iron in thalassemia , 2003, Journal of magnetic resonance imaging : JMRI.

[18]  G. Brittenham,et al.  Noninvasive measurement of iron: report of an NIDDK workshop. , 2003, Blood.

[19]  P. Jensen.  Evaluation of iron overload , 2004, British journal of haematology.

[20]  A. Cnaan,et al.  Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. , 2004, Haematologica.

[21]  T. S. St. Pierre,et al.  Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. , 2005, Blood.

[22]  T. Coates,et al.  MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. , 2005, Blood.

[23]  T. Brown,et al.  Methods for Noninvasive Measurement of Tissue Iron in Cooley's Anemia , 2005, Annals of the New York Academy of Sciences.

[24]  Huaqing Zhao,et al.  1/T2 and magnetic susceptibility measurements in a gerbil cardiac iron overload model. , 2005, Radiology.

[25]  A. Reykowski,et al.  B 1-Homogenization in abdominal imaging at 3 T by means of coupling coils , 2005 .

[26]  R. Muller,et al.  Relaxivities of human liver and spleen ferritin. , 2005, Magnetic resonance imaging.

[27]  T. Coates,et al.  MRI detects myocardial iron in the human heart , 2006, Magnetic resonance in medicine.

[28]  J. Pauly,et al.  Saturated double‐angle method for rapid B1+ mapping , 2006, Magnetic resonance in medicine.

[29]  D. Pennell,et al.  Development of a novel optimized breathhold technique for myocardial T2 measurement in thalassemia , 2006, Journal of magnetic resonance imaging : JMRI.

[30]  Gaby S Pell,et al.  Optimized clinical T2 relaxometry with a standard CPMG sequence , 2006, Journal of magnetic resonance imaging : JMRI.

[31]  V. Positano,et al.  Multislice multiecho T2* cardiovascular magnetic resonance for detection of the heterogeneous distribution of myocardial iron overload , 2006, Journal of magnetic resonance imaging : JMRI.

[32]  T. Coates,et al.  Improved R2* measurements in myocardial iron overload , 2006, Journal of magnetic resonance imaging : JMRI.

[33]  D. Pennell,et al.  A magnetic resonance imaging study of iron overload in hemopoietic stem cell transplant recipients with increased ferritin levels. , 2007, Transplantation proceedings.

[34]  P. Storey,et al.  R2* imaging of transfusional iron burden at 3T and comparison with 1.5T , 2007, Journal of magnetic resonance imaging : JMRI.

[35]  Comparing Myocardial T 2 * and T 2 Measurements in Thalassemia Patients , 2007 .

[36]  D. Pennell,et al.  Black‐blood T2* technique for myocardial iron measurement in thalassemia , 2007, Journal of magnetic resonance imaging : JMRI.

[37]  Krishna S Nayak,et al.  Measurement and characterization of RF nonuniformity over the heart at 3T using body coil transmission , 2008, Journal of magnetic resonance imaging : JMRI.

[38]  W. Au,et al.  A cross-sectional magnetic resonance imaging assessment of organ specific hemosiderosis in 180 thalassemia major patients in Hong Kong , 2008, Haematologica.

[39]  C. Pierpaoli,et al.  Diffusion‐weighted radial fast spin‐echo for high‐resolution diffusion tensor imaging at 3T , 2008, Magnetic resonance in medicine.

[40]  Dudley J Pennell,et al.  Myocardial T  *2 measurement in iron‐overloaded thalassemia: An ex vivo study to investigate optimal methods of quantification , 2008, Magnetic resonance in medicine.

[41]  D. Pennell,et al.  Journal of Cardiovascular Magnetic Resonance Multi-center Transferability of a Breath-hold T2 Technique for Myocardial Iron Assessment , 2008 .

[42]  S. Tam,et al.  A pilot MRI study of organ specific hemosiderosis and functional correlation in Chinese patients with myelodysplasia and aplastic anemia with raised ferritin levels , 2008, Hematological oncology.

[43]  D. Pennell,et al.  One‐stop measurement of iron deposition in the anterior pituitary, liver, and heart in thalassemia patients , 2008, Journal of magnetic resonance imaging : JMRI.

[44]  203 Correlation of myocardial T2 and T2 measurements in thalassemia patients , 2008 .

[45]  E. Wu,et al.  Breathhold multiecho fast spin‐echo pulse sequence for accurate R2 measurement in the heart and liver , 2009, Magnetic resonance in medicine.

[46]  Dudley J Pennell,et al.  On using T2 to assess extrinsic magnetic field inhomogeneity effects on T2* measurements in myocardial siderosis in thalassemia , 2009, Magnetic resonance in medicine.