Well‐Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

Well‐defined tertiary amine‐functionalized cationic polylactides (CPLAs) are synthesized by thiol‐ene click functionalization of an allyl‐functionalized polylactide, and utilized for the delivery of interleukin‐8 (IL‐8) siRNA via CPLA‐IL‐8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA‐IL‐8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL‐8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA‐IL‐8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs.

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