Innate immune recognition of the indigenous microbial flora

Our studies have focused on understanding the mechanisms of interactions between the indigenous intestinal flora and the mammalian host in both physiological and nonphysiological conditions. In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of tissue injury and repair, spontaneous colitis, and postnatal development.

[1]  D. Podolsky The current future understanding of inflammatory bowel disease. , 2002, Best practice & research. Clinical gastroenterology.

[2]  A. Kaur,et al.  The evolution of vertebrate Toll-like receptors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Tao Zhang,et al.  RNA Viral Community in Human Feces: Prevalence of Plant Pathogenic Viruses , 2005, PLoS biology.

[4]  Michael Karin,et al.  Intracellular pattern recognition receptors in the host response , 2006, Nature.

[5]  Myeong Sup Lee,et al.  Signaling pathways downstream of pattern-recognition receptors and their cross talk. , 2007, Annual review of biochemistry.

[6]  P. Mannon,et al.  The fundamental basis of inflammatory bowel disease. , 2007, The Journal of clinical investigation.

[7]  R. Medzhitov Recognition of microorganisms and activation of the immune response , 2007, Nature.

[8]  Ruslan Medzhitov,et al.  Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis , 2004, Cell.

[9]  L. T. Angenent,et al.  Getting a grip on things: how do communities of bacterial symbionts become established in our intestine? , 2004, Nature Immunology.

[10]  S. Akira,et al.  Toll-like receptors. , 2003, Annual review of immunology.

[11]  R. Blumberg,et al.  The immunology of mucosal models of inflammation. , 2002, Annual review of immunology.

[12]  C. Janeway Approaching the asymptote? Evolution and revolution in immunology. , 1989, Cold Spring Harbor symposia on quantitative biology.

[13]  M. Leach,et al.  Chronic Colitis in IL-10-/- Mice: Insufficient Counter Regulation of a Th1 Response , 2000, International reviews of immunology.

[14]  Ruslan Medzhitov,et al.  Role of toll-like receptors in spontaneous commensal-dependent colitis. , 2006, Immunity.

[15]  E. Purdom,et al.  Diversity of the Human Intestinal Microbial Flora , 2005, Science.