Restorative treatment strategies for patients with cleidocranial dysplasia

Abstract Objective. To develop a suitable treatment strategy for patients with cleidocranial dysplasia (CCD) who miss the optimal early treatment stage. Materials and methods. This study enrolled 15 patients with CCD who had all missed the optimal treatment stage and were diagnosed with CCD through clinical examinations and genetic tests. Based on the chief complaints and requirements of the patients, three different therapeutic schedules were devised for these patients. Schedules I (periodontal and endodontic treatments) and II (periodontal, endodontic and prosthodontic treatments) were used for patients with low requirements, whereas Schedule III (multidisciplinary strategy, including periodontal, endodontic, surgical, orthodontic and prosthodontic treatments) was used for patients with high requirements. Results. Schedules I, II and III were used in five, seven and three patients, respectively. Schedule III treatments produced the best outcomes in terms of occlusion and esthetics. Conclusions. Schedule III based on a comprehensive multidisciplinary therapy is an ideal restorative therapeutic strategy and can achieve good outcomes for patients with CCD who missed the optimal treatment stage.

[1]  Robert W Berg,et al.  Interim prosthetic phase of multidisciplinary management of cleidocranial dysplasia: "the Bronx Approach". , 2011, Journal of prosthodontics : official journal of the American College of Prosthodontists.

[2]  Domenico Dalessandri,et al.  Advantages of cone beam computed tomography (CBCT) in the orthodontic treatment planning of cleidocranial dysplasia patients: a case report , 2011, Head & face medicine.

[3]  G. Farronato,et al.  Orthodontic treatment in a patient with cleidocranial dysostosis. , 2009, The Angle orthodontist.

[4]  Chunxia Wang,et al.  Mutations in the RUNX2 gene in Chinese patients with cleidocranial dysplasia. , 2008, Annals of clinical and laboratory science.

[5]  P. Yen,et al.  Intragenic microdeletion of RUNX2 is a novel mechanism for cleidocranial dysplasia , 2008, Genomic Medicine.

[6]  T. Takano-Yamamoto,et al.  Titanium screw anchorage for traction of many impacted teeth in a patient with cleidocranial dysplasia. , 2007, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[7]  G. Sándor,et al.  Cranioplasty for midline metopic suture defects in adults with cleidocranial dysplasia. , 2007, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[8]  J. Daskalogiannakis,et al.  Cleidocranial dysplasia: 2 generations of management. , 2006, Journal.

[9]  B. Boran,et al.  Cleidocranial dysplasia in a mother and her daughter within the scope of neurosurgery. Report of two cases. , 2006, Journal of neurosurgery.

[10]  J. Hilborn,et al.  Intrinsically radiopaque iodine-containing polyvinyl alcohol as a liquid embolic agent: evaluation in experimental wide-necked aneurysms. , 2006, Journal of neurosurgery.

[11]  Z. Suba,et al.  Cleidocranial dysplasia: diagnostic criteria and combined treatment. , 2005, The Journal of craniofacial surgery.

[12]  J. Rebellato,et al.  Dental team management for a patient with cleidocranial dysostosis. , 2005, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[13]  F. Stahl,et al.  Malocclusion and caries prevalence: is there a connection in the primary and mixed dentitions? , 2004, Clinical Oral Investigations.

[14]  S. Mundlos,et al.  Mutation analysis of core binding factor A1 in patients with cleidocranial dysplasia. , 1999, American journal of human genetics.

[15]  S. Mundlos.  Cleidocranial dysplasia: clinical and molecular genetics , 1999, Journal of medical genetics.

[16]  A. Becker,et al.  Cleidocranial dysplasia: Part 2--Treatment protocol for the orthodontic and surgical modality. , 1997, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[17]  S. Kreiborg,et al.  Dental treatment strategies in cleidocranial dysplasia , 1992, British Dental Journal.

[18]  S. Kreiborg,et al.  Development of the dentition in cleidocranial dysplasia. , 1990, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[19]  S. Kreiborg,et al.  Abnormalities of the cranial base in cleidocranial dysostosis. , 1981, American journal of orthodontics.

[20]  S. Järvinen.  Cephalometric findings in three cases of cleidocranial dysostosis. , 1981, American journal of orthodontics.

[21]  Keats Te,et al.  Cleidocranial dysostosis. A review of 40 new cases. , 1974 .

[22]  A. Olszewska.  Dental treatment strategies in a 40-year-old patient with cleidocranial dysplasia , 2010, Journal of Applied Genetics.

[23]  A. Becker,et al.  Cleidocranial dysplasia: Part 1--General principles of the orthodontic and surgical treatment modality. , 1997, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

[24]  P. Petersen,et al.  Causal relation between malocclusion and periodontal health. , 1989, Acta odontologica Scandinavica.