Long-term assessment of the salivary oxidative stress status during orthodontic treatment with fixed appliances

Introduction: Saliva has been considered a valuable diagnostic tool for many disorders and diseases. Objective: The aim of this study was to assess some important biomarkers of oxidative stress in the saliva of patients undergoing fixed orthodontic treatment. Methods: A total of thirty three subjects (18 females and 15 males) in the age group of 1518 years were enrolled in the study. The salivary samples were collected before fixed appliance placement, 6 months and 1 year after orthodontic treatment onset. Samples were investigated for measurement of malondialdehyde (MDA), nitric oxide (NO) and 8-hydroxydeoxyguanosine (8OHdG) levels. Results: The salivary MDA, NO and 8-OHdG concentrations in the individuals treated with fixed orthodontic appliances did not show significant changes neither after 6 nor after 12 months of treatment compared to the basal values before treatment . Conclusion: Fixed orthodontic therapy for one year did not induce oxidative damage in the oral cavity.

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