Cytologic perspectives on neoteric B‐cell lymphoproliferative disorders

The 2008 World Health Organization (WHO) classification of hematopoietic and lymphoid tissues has been recently revised, and publication of the updated 2016 version is expected soon. Given that cytopathologists are often involved in the diagnosis of primary, recurrent, and transformed lymphoproliferative disorders, knowledge of updates to the WHO lymphoma classification, including terminology, pathogenesis, ancillary techniques, and targeted therapies is necessary. Herein, we reference the last decade of cytology specific literature for seven newer B‐cell disorders and provide illustrative examples of each entity from our files.

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[56]  Zhigui Ma,et al.  ALK-positive extramedullary plasmacytoma with expression of the CLTC-ALK fusion transcript. , 2011, Pathology, research and practice.

[57]  G. da Cunha Santos,et al.  Cytomorphologic findings of B‐cell lymphomas with concurrent IGH/BCL2 and MYC rearrangements (dual‐translocation lymphomas) , 2011, Cancer cytopathology.

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[63]  E. Giné,et al.  Expanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia (“accelerated” chronic lymphocytic leukemia) with aggressive clinical behavior , 2010, Haematologica.

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[65]  R. Gascoyne,et al.  Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma: a rare clinicopathologic entity with poor prognosis. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

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[77]  Y. Yamashita,et al.  ALK+, CD30−, CD20− Large B-Cell Lymphoma Containing Anaplastic Lymphoma Kinase (ALK) Fused to Clathrin Heavy Chain Gene (CLTC) , 2003, Modern Pathology.

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