Inhibition of Bcl-2/Bcl-xL and c-MET causes synthetic lethality in model systems of glioblastoma
暂无分享,去创建一个
M. Westhoff | G. Karpel-Massler | M. Siegelin | G. Kleiner | C. Quinzii | C. T. Ishida | E. Bianchetti | Yiru Zhang | C. Shu | M. Sánchez-Quintero | C. Ishida
[1] P. Canoll,et al. Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL , 2017, Nature Communications.
[2] M. Halatsch,et al. Targeting intrinsic apoptosis and other forms of cell death by BH3-mimetics in glioblastoma , 2017, Expert opinion on drug discovery.
[3] P. Canoll,et al. Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses. , 2017, Cancer research.
[4] Georg Karpel-Massler,et al. BH3-mimetics and BET-inhibitors elicit enhanced lethality in malignant glioma , 2017, Oncotarget.
[5] D. Altieri,et al. Mitochondrial matrix chaperone and c-myc inhibition causes enhanced lethality in glioblastoma , 2017, Oncotarget.
[6] B. Teh,et al. Dual modulation of MCL-1 and mTOR determines the response to sunitinib , 2017, The Journal of clinical investigation.
[7] P. Canoll,et al. Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo , 2016, Oncotarget.
[8] L. Greene,et al. A Synthetic Cell-Penetrating Dominant-Negative ATF5 Peptide Exerts Anticancer Activity against a Broad Spectrum of Treatment-Resistant Cancers , 2016, Clinical Cancer Research.
[9] P. Canoll,et al. Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo , 2016, Oncotarget.
[10] P. Canoll,et al. TIC10/ONC201 synergizes with Bcl-2/Bcl-xL inhibition in glioblastoma by suppression of Mcl-1 and its binding partners in vitro and in vivo , 2015, Oncotarget.
[11] Timothy C Ryken,et al. Toward precision medicine in glioblastoma: the promise and the challenges. , 2015, Neuro-oncology.
[12] P. Canoll,et al. Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo , 2015, Oncotarget.
[13] S. Ramaswamy,et al. Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer , 2015, Proceedings of the National Academy of Sciences.
[14] J. C. Ghosh,et al. Adaptive mitochondrial reprogramming and resistance to PI3K therapy. , 2015, Journal of the National Cancer Institute.
[15] P. Canoll,et al. PARP Inhibition Restores Extrinsic Apoptotic Sensitivity in Glioblastoma , 2014, PloS one.
[16] P. Canoll,et al. PI3K and Bcl-2 Inhibition Primes Glioblastoma Cells to Apoptosis through Downregulation of Mcl-1 and Phospho-BAD , 2014, Molecular Cancer Research.
[17] R. Bronson,et al. Inhibition of EGFR Induces a c‐MET‐Driven Stem Cell Population in Glioblastoma , 2014, Stem cells.
[18] S. Fulda,et al. Pan-Mammalian Target of Rapamycin (mTOR) Inhibitor AZD8055 Primes Rhabdomyosarcoma Cells for ABT-737-induced Apoptosis by Down-regulating Mcl-1 Protein* , 2013, The Journal of Biological Chemistry.
[19] M. Siegelin. Inhibition of the mitochondrial Hsp90 chaperone network: a novel, efficient treatment strategy for cancer? , 2013, Cancer letters.
[20] J. Laterra,et al. In Vivo c-Met Pathway Inhibition Depletes Human Glioma Xenografts of Tumor-Propagating Stem-Like Cells. , 2013, Translational oncology.
[21] I. Pollack,et al. YM-155 Potentiates the Effect of ABT-737 in Malignant Human Glioma Cells via Survivin and Mcl-1 Downregulation in an EGFR-Dependent Context , 2013, Molecular Cancer Therapeutics.
[22] J. Maris,et al. ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation. , 2012, Cancer cell.
[23] H. Seol,et al. MET signaling regulates glioblastoma stem cells. , 2012, Cancer research.
[24] M. Siegelin. Utilization of the cellular stress response to sensitize cancer cells to TRAIL-mediated apoptosis , 2012, Expert opinion on therapeutic targets.
[25] I. Pollack,et al. ABT-737 Synergizes with Bortezomib to Induce Apoptosis, Mediated by Bid Cleavage, Bax Activation, and Mitochondrial Dysfunction in an Akt-Dependent Context in Malignant Human Glioma Cell Lines , 2012, Journal of Pharmacology and Experimental Therapeutics.
[26] Daniel P. Stewart,et al. Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration , 2012, Nature Cell Biology.
[27] M. Konopleva,et al. MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex , 2012, Leukemia.
[28] S. Combs,et al. p53-dependent regulation of Mcl-1 contributes to synergistic cell death by ionizing radiation and the Bcl-2/Bcl-XL inhibitor ABT-737 , 2011, Apoptosis.
[29] A. Eastman,et al. Multiple BH3 Mimetics Antagonize Antiapoptotic MCL1 Protein by Inducing the Endoplasmic Reticulum Stress Response and Up-regulating BH3-only Protein NOXA* , 2011, The Journal of Biological Chemistry.
[30] Martin Glas,et al. c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype , 2011, Proceedings of the National Academy of Sciences.
[31] G. Riggins,et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. , 2010, Cancer research.
[32] T. Kuwana,et al. BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak* , 2010, The Journal of Biological Chemistry.
[33] V. Seifert,et al. The Pan-Bcl-2 Inhibitor (−)-Gossypol Triggers Autophagic Cell Death in Malignant Glioma , 2010, Molecular Cancer Research.
[34] Derek W. Yecies,et al. Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1. , 2010, Blood.
[35] R. McLendon,et al. IDH1 and IDH2 mutations in gliomas. , 2009, The New England journal of medicine.
[36] Philippe Pierre,et al. SUnSET, a nonradioactive method to monitor protein synthesis , 2009, Nature Methods.
[37] Qiuyan Wang,et al. ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells , 2009, Proceedings of the National Academy of Sciences.
[38] J. Uhm. An Integrated Genomic Analysis of Human Glioblastoma Multiforme , 2009 .
[39] O. Wiestler,et al. Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins , 2008, Oncogene.
[40] Laurent Bélec,et al. Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis , 2007, Proceedings of the National Academy of Sciences.
[41] E. Campo,et al. The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. , 2007, Blood.
[42] T. Taniguchi,et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. , 2000, Science.