Health and Racial Disparity in Breast Cancer.

Breast cancer is the most common noncutaneous malignancy and the second most lethal form of cancer among women in the United States. It currently affects more than one in ten women worldwide. The chance for a female to be diagnosed with breast cancer during her lifetime has significantly increased from 1 in 11 women in 1975 to 1 in 8 women (Altekruse, SEER Cancer Statistics Review, 1975-2007. National Cancer Institute, Bethesda, 2010). This chance for a female of being diagnosed with cancer generally increases with age (Howlader et al, SEER Cancer Statistics Review, 1975-2010. National Cancer Institute, Bethesda, 2013). Fortunately, the mortality rate from breast cancer has decreased in recent years due to increased emphasis on early detection and more effective treatments in the White population. Although the mortality rates have declined in some ethnic populations, the overall cancer incidence among African American and Hispanic population has continued to grow. The goal of the work presented in this book chapter is to highlight similarities and differences in breast cancer morbidity and mortality rates among non-Hispanic white and non-Hispanic black populations. This book chapter also provides an overview of breast cancer, racial/ethnic disparities in breast cancer, breast cancer incidence and mortality rate linked to hereditary, major risk factors of breast cancer among minority population, breast cancer treatment, and health disparity. A considerable amount of breast cancer treatment research have been conducted, but with limited success for African Americans compared to other ethnic groups. Therefore, new strategies and approaches are needed to promote breast cancer prevention, improve survival rates, reduce breast cancer mortality, and ultimately improve the health outcomes of racial/ethnic minorities. In addition, it is vital that leaders and medical professionals from minority population groups be represented in decision-making in research so that racial disparity in breast cancer can be well-studied, fully addressed, and ultimately eliminated in breast cancer.

[1]  N. Boyd,et al.  A Meta-Analysis of Published Literature on Waist-to-Hip Ratio and Risk of Breast Cancer , 2002, Nutrition and cancer.

[2]  R. Coates,et al.  Racial differences in the expression of cell cycle–regulatory proteins in breast carcinoma , 2004, Cancer.

[3]  M. G. Curnen,et al.  Severe obesity as an explanatory factor for the black/white difference in stage at diagnosis of breast cancer. , 1997, American journal of epidemiology.

[4]  G W Heath,et al.  Leisure-time physical activity among US adults. Results from the Third National Health and Nutrition Examination Survey. , 1996, Archives of internal medicine.

[5]  G. Colditz,et al.  Priorities for the primary prevention of breast cancer , 2014, CA: a cancer journal for clinicians.

[6]  M. van Ryn,et al.  The effect of patient race and socio-economic status on physicians' perceptions of patients. , 2000, Social science & medicine.

[7]  M. Pike,et al.  American Journal of Epidemiology Original Contribution Breast Cancer Risk Factors Defined by Estrogen and Progesterone Receptor Status the Multiethnic Cohort Study , 2022 .

[8]  Mary A. Gerend,et al.  Social Determinants of Black-White Disparities in Breast Cancer Mortality: A Review , 2008, Cancer Epidemiology Biomarkers & Prevention.

[9]  Randolph G. Potts Spirituality and the experience of cancer in an African-American community : Implications for psychosocial oncology , 1996 .

[10]  Alice S Whittemore,et al.  Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups. , 2007, JAMA.

[11]  W. Kannel,et al.  Avoiding the looming Latino/Hispanic cardiovascular health crisis: a call to action. , 2007, Journal of the cardiometabolic syndrome.

[12]  J. Hopper,et al.  Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies. , 2003, American journal of human genetics.

[13]  F. Clavel-Chapelon,et al.  Recent Recreational Physical Activity and Breast Cancer Risk in Postmenopausal Women in the E3N Cohort , 2014, Cancer Epidemiology, Biomarkers & Prevention.

[14]  D. King,et al.  The doctor as God's mechanic? Beliefs in the Southeastern United States. , 2002, Social science & medicine.

[15]  W. McCaskill-Stevens,et al.  p53 as a Marker of Prognosis in African-American Women with Breast Cancer , 2010, Annals of Surgical Oncology.

[16]  H. Kraemer,et al.  Diurnal cortisol rhythm as a predictor of breast cancer survival. , 2000, Journal of the National Cancer Institute.

[17]  David R. Williams,et al.  Social sources of racial disparities in health. , 2005, Health affairs.

[18]  Ping Sun,et al.  Differences in breast cancer stage at diagnosis and cancer-specific survival by race and ethnicity in the United States. , 2015, JAMA.

[19]  D. Rose,et al.  Obesity, adipocytokines, and insulin resistance in breast cancer , 2004, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[20]  Anna M. Miller,et al.  Attitudes about breast cancer and mammography: racial, income, and educational differences. , 1997, Women & health.

[21]  P. Winstead-Fry,et al.  The relationship of rural persons' multidimensional health locus of control to knowledge of cancer, cancer myths, and cancer danger signs. , 1999, Cancer Nursing.

[22]  R. Stephens,et al.  Differences in the Tumor Microenvironment between African-American and European-American Breast Cancer Patients , 2009, PloS one.

[23]  Racial Differences in Health Insurance Coverage and Medical Expenditures in the United States , 2006, Social Science History.

[24]  R. Goldbohm,et al.  Socioeconomic status and breast cancer incidence: a prospective cohort study. , 1994, International Journal of Epidemiology.

[25]  Ahmedin Jemal,et al.  Cancer Disparities by Race/Ethnicity and Socioeconomic Status , 2004, CA: a cancer journal for clinicians.

[26]  M. Kotepui Diet and risk of breast cancer , 2016, Contemporary oncology.

[27]  Diana S. M. Buist,et al.  Genome-wide copy number alterations in subtypes of invasive breast cancers in young white and African American women , 2011, Breast Cancer Research and Treatment.

[28]  G. Parmigiani,et al.  Estrogen Receptor/Progesterone Receptor-Negative Breast Cancers of Young African-American Women Have a Higher Frequency of Methylation of Multiple Genes than Those of Caucasian Women1 , 2004, Clinical Cancer Research.

[29]  B. Devellis,et al.  Breast Cancer in African‐American Families , 1995 .

[30]  T. Laveist,et al.  Race of physician and satisfaction with care among African-American patients. , 2002, Journal of the National Medical Association.

[31]  S. Cleary,et al.  Cancer knowledge, attitudes, beliefs, and practices (KABP) of disadvantaged women in the South Bronx. , 2009, Journal of cancer education : the official journal of the American Association for Cancer Education.

[32]  C. C. Johnson,et al.  Race and differences in breast cancer survival in a managed care population. , 1999, Journal of the National Cancer Institute.

[33]  C. Redmond,et al.  Breast cancer: factors associated with stage at diagnosis in black and white women. Black/White Cancer Survival Study Group. , 1993, Journal of the National Cancer Institute.

[34]  J. Palmer,et al.  Parity and Lactation in Relation to Estrogen Receptor Negative Breast Cancer in African American Women , 2011, Cancer Epidemiology, Biomarkers & Prevention.

[35]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[36]  J. Phillips,et al.  Adherence to breast cancer screening guidelines among African‐American women of differing employment status , 1995, Cancer nursing.

[37]  H. P. Cooper,et al.  Breast cancer screening: racial/ethnic differences in behaviors and beliefs. , 2009, Journal of cancer education : the official journal of the American Association for Cancer Education.

[38]  Christopher B. Forrest,et al.  Adherence of low-income women to cancer screening recommendations , 2002, Journal of general internal medicine.

[39]  T. Walsh,et al.  Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. , 2006, JAMA.

[40]  C. Mathers,et al.  Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 , 2015, International journal of cancer.

[41]  G M Clark,et al.  Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States. , 1994, Journal of the National Cancer Institute.

[42]  C. Ulrich,et al.  Postdiagnosis diet quality, the combination of diet quality and recreational physical activity, and prognosis after early-stage breast cancer , 2011, Cancer Causes & Control.

[43]  H. Freeman,et al.  Determinants of cancer disparities: barriers to cancer screening, diagnosis, and treatment. , 2005, Surgical oncology clinics of North America.

[44]  W. Foulkes,et al.  Hereditary breast cancer: new genetic developments, new therapeutic avenues , 2008, Human Genetics.

[45]  B. Polite,et al.  Triple-Negative Breast Cancers: A View From 10,000 Feet , 2010, Cancer journal.

[46]  T. Cummins,et al.  Obstacles to cancer care: focus on the economically disadvantaged. , 1994, Oncology Nursing Forum.

[47]  B. Stoll Western diet, early puberty, and breast cancer risk , 1998, Breast Cancer Research and Treatment.

[48]  Giske Ursin,et al.  Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. , 2006, Cancer research.

[49]  S. Land,et al.  African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer. , 2009, Cancer epidemiology.

[50]  L. Kao,et al.  The Effect of Age on Race-Related Breast Cancer Survival Disparities , 2013, Annals of Surgical Oncology.

[51]  T. Dörk,et al.  Hereditary breast cancer: ever more pieces to the polygenic puzzle , 2013, Hereditary Cancer in Clinical Practice.

[52]  S. Heymsfield,et al.  Estrogen Receptor Status and Dietary Intakes in Breast Cancer Patients , 1993, Epidemiology.

[53]  K. Courneya,et al.  Associations among physical activity, body mass index, and health‐related quality of life by race/ethnicity in a diverse sample of breast cancer survivors , 2012, Cancer.

[54]  Gary L. Kreps,et al.  Guidelines for International Breast Health and Cancer Control – Implementation Supplement to Cancer Guideline Implementation for Breast Healthcare in Low-and Middle-Income Countries Early Detection Resource Allocation , 2008 .

[55]  S. Gapstur,et al.  Recreational Physical Activity and Leisure-Time Sitting in Relation to Postmenopausal Breast Cancer Risk , 2013, Cancer Epidemiology, Biomarkers & Prevention.

[56]  E. Long Breast cancer in African-American women. Review of the literature. , 1993, Cancer nursing.

[57]  L. Egede,et al.  Epidemiology of type 2 diabetes: focus on ethnic minorities. , 2005, The Medical clinics of North America.

[58]  D. Ansell,et al.  The black:white disparity in breast cancer mortality: the example of Chicago , 2007, Cancer Causes & Control.

[59]  A. Jemal,et al.  Global cancer statistics, 2012 , 2015, CA: a cancer journal for clinicians.

[60]  A. Jemal,et al.  Breast cancer statistics, 2015: Convergence of incidence rates between black and white women , 2016, CA: a cancer journal for clinicians.

[61]  C. Ulrich,et al.  Postdiagnosis Diet Quality Is Inversely Related to a Biomarker of Inflammation among Breast Cancer Survivors , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[62]  H. Olsson Cancer risks in BRCA2 mutation carriers. , 1999, Journal of the National Cancer Institute.

[63]  N. Risch,et al.  Age at onset as an indicator of familial risk of breast cancer. , 1990, American journal of epidemiology.

[64]  Jane E. Carpenter,et al.  A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer , 2011, Nature Genetics.

[65]  Loki Natarajan,et al.  Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized trial. , 2007, JAMA.

[66]  K. Flegal,et al.  Prevalence of overweight and obesity in the United States, 1999-2004. , 2006, JAMA.

[67]  C. Perou,et al.  Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. , 2006, JAMA.

[68]  A. Jemal,et al.  Cancer statistics, 2017 , 2017, CA: a cancer journal for clinicians.

[69]  S. Leinster,et al.  A Comparison of Clinicopathological Features and Molecular Markers in British and Nigerian Women with Breast Cancer , 2008, Clinical medicine. Oncology.

[70]  M. Arthur,et al.  Physician referral patterns and race differences in receipt of coronary angiography. , 2002, Health services research.

[71]  Bernard Rachet,et al.  Cancer survival in five continents: a worldwide population-based study (CONCORD). , 2008, The Lancet. Oncology.

[72]  Judy Kruger,et al.  Prevalence of regular physical activity among adults--United States, 2001 and 2005. , 2007, MMWR. Morbidity and mortality weekly report.

[73]  S. Edge,et al.  Impact of body mass index on clinical outcomes in triple‐negative breast cancer , 2011, Cancer.

[74]  D M Parkin,et al.  16. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010 , 2011, British Journal of Cancer.

[75]  D. Schrag,et al.  Missed opportunities: racial disparities in adjuvant breast cancer treatment. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[76]  D. Nerenz,et al.  Comorbidity and survival disparities among black and white patients with breast cancer. , 2005, JAMA.

[77]  L. Newman,et al.  Disparities in breast cancer. , 2007, Current problems in cancer.

[78]  D. Horsman,et al.  Breast cancer risks in women with a family history of breast or ovarian cancer who have tested negative for a BRCA1 or BRCA2 mutation , 2008, British Journal of Cancer.

[79]  N. Nock,et al.  Race, Age, and Obesity Disparities in Adult Physical Activity Levels in Breast Cancer Patients And Controls , 2014, Front. Public Health.

[80]  P. Tchounwou,et al.  Assessing the Racial and Ethnic Disparities in Breast Cancer Mortality in the United States , 2017, International journal of environmental research and public health.

[81]  B. Hailey,et al.  Cancer anxiety and breast cancer screening in African-American women: a preliminary study. , 1994, Women's health issues : official publication of the Jacobs Institute of Women's Health.

[82]  L. Natarajan,et al.  Was race a factor in the outcomes of the women's health eating and living study? , 2011, Cancer.

[83]  I. Thompson,et al.  Race, treatment, and long-term survival from prostate cancer in an equal-access medical care delivery system. , 1995, JAMA.

[84]  W. Willett,et al.  Physical activity and risk of breast cancer among postmenopausal women. , 2010, Archives of internal medicine.

[85]  Giovanni Parmigiani,et al.  Meta-analysis of BRCA1 and BRCA2 penetrance. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[86]  S. Hankinson,et al.  Racial Differences in Premenopausal Endogenous Hormones , 2005, Cancer Epidemiology Biomarkers & Prevention.

[87]  D. Whiteman,et al.  Physical activity and cancer prevention: a systematic review of clinical trials , 2011, Cancer Causes & Control.

[88]  M. Rossing,et al.  Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients , 2007, Breast Cancer Research.

[89]  C K Redmond,et al.  Racial differences in survival from breast cancer. Results of the National Cancer Institute Black/White Cancer Survival Study. , 1994, JAMA.

[90]  L. Bernstein,et al.  Ethnicity‐related variation in breast cancer risk factors , 2003, Cancer.

[91]  A. Olshan,et al.  Racial differences in physical activity among breast cancer survivors: Implications for breast cancer care , 2014, Cancer.

[92]  Robyn Tamblyn,et al.  Association between licensure examination scores and practice in primary care. , 2002, JAMA.

[93]  A. Jemal,et al.  Breast Cancer Statistics , 2013 .

[94]  R. Goldbohm,et al.  Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58 209 women with breast cancer and 101 986 women without the disease , 2001, The Lancet.

[95]  MPH Dr. Ann S. O’Malley MD,et al.  Adherence of low-income women to cancer screening recommendations , 2007, Journal of General Internal Medicine.

[96]  E. Lustbader,et al.  Ethnic differences in risk perception among women at increased risk for breast cancer , 2005, Breast Cancer Research and Treatment.

[97]  M. Swanson,et al.  Impacting cultural attitudes in African-American women to decrease breast cancer mortality. , 2002, American journal of surgery.

[98]  Dongfeng Zhang,et al.  Physical activity and risk of breast cancer: a meta-analysis of prospective studies , 2013, Breast Cancer Research and Treatment.

[99]  C. Ritenbaugh,et al.  Breast cancer risk and lifestyle differences among premenopausal and postmenopausal African‐American women and white women , 2003, Cancer.

[100]  Zhao Chen,et al.  Ethnicity and breast cancer: factors influencing differences in incidence and outcome. , 2005, Journal of the National Cancer Institute.

[101]  D. Parkin 1. The fraction of cancer attributable to lifestyle and environmental factors in the UK in 2010 , 2011, British Journal of Cancer.

[102]  J. Tulsky,et al.  The Influence of Spiritual Beliefs and Practices on the Treatment Preferences of African Americans: A Review of the Literature , 2005, Journal of the American Geriatrics Society.

[103]  Nazneen Rahman,et al.  Breast-cancer risk in families with mutations in PALB2. , 2014, The New England journal of medicine.

[104]  H. Freeman Poverty, Culture, and Social Injustice: Determinants of Cancer Disparities , 2004, CA: a cancer journal for clinicians.

[105]  S. Vernon,et al.  Factors associated with perceived risk of breast cancer among women attending a screening program , 1993, Breast Cancer Research and Treatment.

[106]  L. Gerber,et al.  A prospective surveillance model for rehabilitation for women with breast cancer , 2012, Cancer.

[107]  R. Coates,et al.  Race, nutritional status, and survival from breast cancer. , 1990, Journal of the National Cancer Institute.

[108]  A. Nattinger,et al.  The influence of black race and socioeconomic status on the use of breast‐conserving surgery for medicare beneficiaries , 1997, Cancer.

[109]  C. Skinner,et al.  Knowledge, perceptions, and mammography stage of adoption among older urban women. , 1998, American journal of preventive medicine.

[110]  A. Jemal,et al.  Breast cancer statistics, 2013 , 2014, CA: a cancer journal for clinicians.

[111]  Chronic Disease Division Cancer facts and figures , 2010 .

[112]  C. Hennekens,et al.  Hypertension: trends, risks, drug therapies and clinical challenges in African Americans. , 2004, Ethnicity & disease.

[113]  Elvan C. Daniels,et al.  Perceptions about breast cancer among African American women: do selected educational materials challenge them? , 2005, Patient education and counseling.

[114]  D W Baker,et al.  Health literacy among Medicare enrollees in a managed care organization. , 1999, JAMA.

[115]  S. Yao,et al.  Associations between vitamin D deficiency and risk of aggressive breast cancer in African-American women , 2013, The Journal of Steroid Biochemistry and Molecular Biology.

[116]  M. Holmes,et al.  Disparities across the breast cancer continuum , 2005, Cancer Causes & Control.

[117]  M S Swanson,et al.  Influence of socioeconomic and cultural factors on racial differences in late-stage presentation of breast cancer. , 1998, JAMA.

[118]  E. Feuer,et al.  SEER Cancer Statistics Review, 1975-2003, National Cancer Institute. Bethesda, MD, , 2006 .

[119]  D. A. Dawson,et al.  Breast cancer risk factors and screening: United States, 1987. , 1990, Vital and health statistics. Series 10, Data from the National Health Survey.

[120]  Robert M Elashoff,et al.  Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. , 2007, Journal of the National Cancer Institute.

[121]  B. Rosner,et al.  Differences in serum sex hormone and plasma lipid levels in Caucasian and African-American premenopausal women. , 2005, The Journal of clinical endocrinology and metabolism.

[122]  L. Lacey,et al.  Referral adherence in an inner city breast and cervical cancer screening program , 1993, Cancer.

[123]  M. Mayo,et al.  Local recurrence following breast conservation therapy in African-American women with invasive breast cancer. , 2000, American journal of surgery.

[124]  Beth Newman,et al.  Comparative Analysis of Breast Cancer Risk Factors among African-American Women and White Women , 2005 .

[125]  Deborah Schrag,et al.  Primary care physicians who treat blacks and whites. , 2004, The New England journal of medicine.

[126]  C. Ellison,et al.  Turning to prayer: Social and situational antecedents of religious coping among African Americans , 1996 .

[127]  C. M. Tammemagi,et al.  Racial/ethnic disparities in breast and gynecologic cancer treatment and outcomes , 2007, Current opinion in obstetrics & gynecology.