Tapered Fibre Optic Biosensor (TFOBS) by Optically Controlled Etching for Label-Free Glucose Concentration Monitoring - Biomedical Optics

This paper proposes, designs and demonstrates experimentally a tapered fibre optic biosensor (TFOBS) fabricated by an optically controlled HF chemical etching. The fabricated device is demonstrated to operate properly as a label-free sensor for glucose concentration detection. This work presents a novel fabrication method of a single-mode TFOBS controlling the reaction rate by changing the HF concentration and monitoring the optical power variation at the fibre output. Two TFOBS fabricated with different cladding diameters are evaluated experimentally to sense different glucose concentrations observing the changes in the refractive index of the medium in various solvents. The sensing capabilities are evaluated by modal interferometry measurement of both intensity and phase variations of the received optical signal.

[1]  Timothy A. Birks,et al.  Control of optical fibre taper shape , 1991 .

[2]  C. Davis,et al.  Tapered single-mode optical fiber evanescent coupling , 2002, IEEE Photonics Technology Letters.

[3]  P. M. Shankar,et al.  Fabrication of biconical tapered optical fibers using hydrofluoric acid , 2003 .

[4]  M. Mansuripur,et al.  Evanescent field-based optical fiber sensing device for measuring the refractive index of liquids in microfluidic channels. , 2005, Optics letters.

[5]  Jean-Michel Hartmann,et al.  A Review of Different and Promising Defect Etching Techniques: from Si to Ge , 2007, ECS Transactions.

[6]  María Espinosa Bosch,et al.  Recent Development in Optical Fiber Biosensors , 2007, Sensors (Basel, Switzerland).

[7]  Raj Mutharasan,et al.  Model protein detection using antibody-immobilized tapered fiber optic biosensors (TFOBS) in a flow cell at 1310 nm and 1550 nm , 2008 .

[8]  H. Ebendorff-Heidepriem,et al.  Antibody immobilization within glass microstructured fibers: a route to sensitive and selective biosensors , 2008, International Conference on Optical Fibre Sensors.

[9]  Raj Mutharasan,et al.  Label-free detection of DNA hybridization using gold-coated tapered fiber optic biosensors (TFOBS) in a flow cell at 1310 nm and 1550 nm , 2008 .

[10]  Hamid Latifi,et al.  Non-adiabatic tapered optical fiber sensor for measuring the interaction between α-amino acids in aqueous carbohydrate solution , 2010 .

[11]  K. Sode,et al.  Review of Glucose Oxidases and Glucose Dehydrogenases: A Bird's Eye View of Glucose Sensing Enzymes , 2011, Journal of diabetes science and technology.

[12]  David C Klonoff,et al.  Overview of Fluorescence Glucose Sensing: A Technology with a Bright Future , 2012, Journal of diabetes science and technology.

[13]  G. A. Cárdenas-Sevilla,et al.  Optical microfiber mode interferometer for temperature-independent refractometric sensing. , 2012, Optics letters.

[14]  Fotios Sidiroglou,et al.  Uniformly thinned optical fibers produced via HF etching with spectral and microscopic verification. , 2012, Applied optics.

[15]  Meihua Bi,et al.  A Sensitivity-Enhanced Refractive Index Sensor Using a Single-Mode Thin-Core Fiber Incorporating an Abrupt Taper , 2012, Sensors.

[16]  E. Baude.  Numerical study of tapered fiber optics as evanescent field sensors , 2013, 2013 SBMO/IEEE MTT-S International Microwave & Optoelectronics Conference (IMOC).

[17]  Santosh B. Noronha,et al.  Glucose oxidase enzyme immobilized porous silica for improved performance of a glucose biosensor , 2014 .

[18]  E. Salik,et al.  Detection of Botulinum Neurotoxin by Tapered Fiber Optic Biosensor , 2014 .

[19]  M. Mahdi,et al.  Single mode tapered fiber-optic interferometer based refractive index sensor and its application to protein sensing. , 2014, Optics express.

[20]  Xue Chenyang,et al.  Micro double tapered optical fiber sensors based on the evanescent field-effect and surface modification , 2014 .

[21]  Chao Zhang,et al.  A novel graphene-based tapered optical fiber sensor for glucose detection , 2015 .

[22]  Guido A. Drago,et al.  Bioconjugation and stabilisation of biomolecules in biosensors , 2016, Essays in biochemistry.

[23]  Junsu Lee,et al.  Chemical Wet Etching of an Optical Fiber Using a Hydrogen Fluoride-Free Solution for a Saturable Absorber Based on the Evanescent Field Interaction , 2016, Journal of Lightwave Technology.