Noradrenergic and serotoninergic innervation of cortical, thalamic, and tectal visual structures in old and new world monkeys

Antisera directed against human dopamine‐ß‐hydroxylase and against serotonin were used to characterize the noradrenergic (NA) and serotoninergic (5‐HT) innervation of several cortical and subcortical visual areas in squirrel monkey (Saimiri sciureus) and cynomolgus monkey (Macaca fascicularis). Few species differences were observed for either monoamine. Cortical areas 17 and 18, as well as visual areas in the temporal and parietal lobe were found to exhibit regional specialization of both 5‐HT and NA innervation. Precisely at the border between areas 17 and 18, the laminar innervation patterns and density characteristic of NA fibers in area 17 (Morrison et al., '82a; Kosofsky et al., '84) shift so that layer IV of area 18 contains more fibers than layer IV of area 17, and the overall density of fibers in area 18 is higher. For 5‐HT, the highly laminated patterns characteristic of area 17 (Morrison et al., '82a; Kosofsky et al., '84) also observe this cytoarchitectonic boundary. Fibers in area 18 are more evenly distributed across laminae, and the overall density of fibers decreases. The visual region of the inferotemporal cortex was found to be very lightly innervated by NA fibers and very densely innervated by 5‐HT fibers. Area 7 of the parietal lobule was more densely innervated by NA fibers, and less densely innervated by 5‐HT fibers, than any other visual cortical region examined.

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