Petals of Crocus sativus L. as a potential source of the antioxidants crocin and kaempferol.

[1]  P. Drummond,et al.  Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action , 2014, Human psychopharmacology.

[2]  S. Akhondzadeh,et al.  Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double‐blind randomized clinical trial , 2014, Human psychopharmacology.

[3]  R. Budriesi,et al.  Phytoestrogens as natural prodrugs in cancer prevention: towards a mechanistic model , 2014, Phytochemistry Reviews.

[4]  G. Alonso,et al.  Flavonoid Determination in the Quality Control of Floral Bioresidues from Crocus sativus L. , 2014, Journal of agricultural and food chemistry.

[5]  G. Alonso,et al.  Cytotoxic effect against 3T3 fibroblasts cells of saffron floral bio-residues extracts. , 2014, Food chemistry.

[6]  A. Nikbakht Nasrabadi,et al.  Heart Palpitation From Traditional and Modern Medicine Perspectives , 2014, Iranian Red Crescent medical journal.

[7]  A. Hensel,et al.  Effective isolation protocol for secondary metabolites from saffron: semi-preparative scale preparation of crocin-1 and trans-crocetin. , 2014, Fitoterapia.

[8]  A. Granell,et al.  Crocins with High Levels of Sugar Conjugation Contribute to the Yellow Colours of Early-Spring Flowering Crocus Tepals , 2013, PloS one.

[9]  S. Joukar,et al.  Protective effects of saffron (Crocus sativus) against lethal ventricular arrhythmias induced by heart reperfusion in rat: A potential anti-arrhythmic agent , 2013, Pharmaceutical biology.

[10]  A. Sahebkar,et al.  A Survey on Saffron in Major Islamic Traditional Medicine Books , 2013, Iranian journal of basic medical sciences.

[11]  Farid Chemat,et al.  Identification and quantification of flavonols, anthocyanins and lutein diesters in tepals of Crocus sativus by ultra performance liquid chromatography coupled to diode array and ion trap mass spectrometry detections , 2013 .

[12]  G. Alonso,et al.  Increasing the applications of Crocus sativus flowers as natural antioxidants. , 2012, Journal of food science.

[13]  H. Hara,et al.  Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice. , 2012, European journal of pharmacology.

[14]  M. Golechha,et al.  Crocus sativus L. (saffron) attenuates isoproterenol-induced myocardial injury via preserving cardiac functions and strengthening antioxidant defense system. , 2012, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

[15]  S. A. H. Goli,et al.  Phenolic Compounds and Antioxidant Activity from Saffron (Crocus sativus L.) Petal , 2012 .

[16]  M. Maldini,et al.  Radical scavenging activity and LC-MS metabolic profiling of petals, stamens, and flowers of Crocus sativus L. , 2012, Journal of food science.

[17]  S. Bisti,et al.  A Longitudinal Follow-Up Study of Saffron Supplementation in Early Age-Related Macular Degeneration: Sustained Benefits to Central Retinal Function , 2012, Evidence-based complementary and alternative medicine : eCAM.

[18]  S. Akhondzadeh,et al.  Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial , 2012, Psychopharmacology.

[19]  S. Anant,et al.  Crocetin: an agent derived from saffron for prevention and therapy for cancer. , 2012, Current pharmaceutical biotechnology.

[20]  M. Manfait,et al.  Embolization of hepatocellular carcinoma with drug-eluting beads: doxorubicin tissue concentration and distribution in patient liver explants. , 2011, Journal of hepatology.

[21]  S. Samarghandian,et al.  Suppression of Pulmonary Tumor Promotion and Induction of Apoptosis by Crocus sativus L. Extraction , 2011, Applied biochemistry and biotechnology.

[22]  E. Karimi,et al.  Evaluation of Crocus sativus L. Stigma Phenolic and Flavonoid Compounds and Its Antioxidant Activity , 2010, Molecules.

[23]  R. B. Saxena.  Botany, Taxonomy and Cytology of Crocus sativus series , 2010, Ayu.

[24]  Haitao Luo,et al.  Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc , 2010, Cancer Cell International.

[25]  A. Mitchell,et al.  Content of ascorbic acid, quercetin, kaempferol and total phenolics in commercial broccoli , 2009 .

[26]  S. Akhondzadeh,et al.  A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer’s disease , 2009, Psychopharmacology.

[27]  M. Maldini,et al.  Qualitative Profile and Quantitative Determination of Flavonoids from Crocus Sativus L. Petals by LC-MS/MS , 2008 .

[28]  A. Romani,et al.  Characterization of By-products of Saffron (Crocus Sativus L.) Production , 2008 .

[29]  W. Ahn,et al.  Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells , 2008, Nutrition research and practice.

[30]  A. Termentzi,et al.  LC-DAD-MS (ESI+) Analysis and Antioxidant Capacity of Crocus sativus Petal Extracts , 2008, Planta medica.

[31]  B. Ravishankar,et al.  Indian systems of medicine: a brief profile. , 2008, African journal of traditional, complementary, and alternative medicines : AJTCAM.

[32]  Z. Qian,et al.  Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats. , 2007, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[33]  E. Sen,et al.  Kaempferol induces apoptosis in glioblastoma cells through oxidative stress , 2007, Molecular Cancer Therapeutics.

[34]  M. Heinonen,et al.  Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated , 2007, Mediators of inflammation.

[35]  S. Akhondzadeh,et al.  Comparison of petal of Crocus sativus L. and fluoxetine in the treatment of depressed outpatients: A pilot double-blind randomized trial , 2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[36]  A. Zalacain,et al.  Identification of the flavonoid fraction in saffron spice by LC/DAD/MS/MS: Comparative study of samples from different geographical origins , 2007 .

[37]  S. Akhondzadeh,et al.  Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. , 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[38]  H. Hosseinzadeh,et al.  Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs. , 2006, Fitoterapia.

[39]  A. Asai,et al.  Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice. , 2005, Journal of agricultural and food chemistry.

[40]  S. Akhondzadeh,et al.  Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. , 2005, Journal of ethnopharmacology.

[41]  P. Limtrakul,et al.  Inhibition of P-Glycoprotein Function and Expression by Kaempferol and Quercetin , 2005, Journal of chemotherapy.

[42]  Y. Shoyama,et al.  Crocin prevents the death of PC-12 cells through sphingomyelinase-ceramide signaling by increasing glutathione synthesis , 2004, Neurochemistry International.

[43]  Tian-Shung Wu,et al.  Antityrosinase principles and constituents of the petals of Crocus sativus. , 2004, Journal of natural products.

[44]  J. J. Espinosa-Aguirre,et al.  Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. , 2004, Cancer detection and prevention.

[45]  H. Hosseinzadeh,et al.  Kaempferol from Saffron Petals , 2003 .

[46]  M. Fatehi,et al.  Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. , 2003, Journal of ethnopharmacology.

[47]  E. Goh,et al.  Evaluation of the developmental toxicity of crocetin on Xenopus. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[48]  H. Hosseinzadeh,et al.  Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice , 2002, BMC pharmacology.

[49]  M. B. Arnao,et al.  A method to measure antioxidant activity in organic media: application to lipophilic vitamins , 2000, Redox report : communications in free radical research.

[50]  H. Riese,et al.  Effects of long-term treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): an experimental study in the rat. , 1999, Nutrition and cancer.

[51]  P. Winterhalter,et al.  Two Kaempferol Sophorosides from Crocus Sativus , 1997 .

[52]  G. Alonso,et al.  Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. , 1996, Cancer letters.