Why do Euphorbiaceae tick as medicinal plants? : a review of Euphorbiaceae family and its medicinal features

Euphorbiaceae is among the large flowering plant families consisting of a wide variety of vegetative forms some of which are plants of great importance. Its classification and chemistry have of late been subjects of interest possibly because of the wide variety of chemical composition of its members, many of which are poisonous but useful. In this review, we have tried to demonstrate why Euphorbiaceae are important medicinal plants. Two important issues have come up. The worldwide distribution of the family exposes its members, to all sorts of habitats to which they must adapt, therefore inducing a large variety of chemicals (secondary substances) that are employed for survival/defense. Succulence and the CAM (crassulacean acid metabolism) pathway that characterize a good number of its members were quoted as some of the adaptations that aid colonization and survival to achieve this induction. We have also found out that medicinal properties of some of its species may be due to stress factors that characterize most habitats of the family. Varying stress factors like temperature, salinity, drought and others were seen to operate in tandem with genetic factors such as gene expression and mutation loads to bring about synthesis of a wide assemblage of secondary substances that may probably be responsible for the family’s medicinal nature. It was concluded that the family is a good starting point for the search for plant-based medicines.

[1]  G. Webster CONSPECTUS OF A NEW CLASSIFICATION OF THE EUPHORBIACEAE , 1975 .

[2]  J. Gershenzon,et al.  Secondary metabolites and the higher classification of angiosperms [Systematic use, taxonomic markers] , 1983 .

[3]  J. Duke Handbook of Energy Crops. , 1983 .

[4]  P. Jurberg,et al.  Molluscicide activity of the "avelós" plant (Euphorbia tirucalli, L.) on Biomphalaria glabrata, the mollusc vector of schistosomiasis. , 1985, Memorias do Instituto Oswaldo Cruz.

[5]  M. Haine,et al.  Van Damme A. , 1986 .

[6]  K. J. Mampane,et al.  Jatropha curcas: Use as a traditional Tswana medicine and its role as a cause of acute poisoning , 1987 .

[7]  A. Rizk The chemical constituents and economic plants of the Euphorbiaceae , 1987 .

[8]  K. Shudo,et al.  A new tumor promoter from the seed oil of Jatropha curcas L., an intramolecular diester of 12-deoxy-16-hydroxyphorbol. , 1988, Cancer research.

[9]  F. Prado,et al.  Effect of lectins on Ricinus invertase , 1991 .

[10]  R. Henderson Studies in Euphorbiaceae A.L.Juss., sens. lat. I.* A revision of Amperea Adr. Juss. (Acalyphoideae Ascherson, Amphereae Muell. Arg.) , 1992 .

[11]  T. Cavalier-smith Origins of secondary metabolism. , 2007, Ciba Foundation symposium.

[12]  G. Lancini,et al.  Biosynthesis of Secondary Metabolites , 1993 .

[13]  G. Webster Classification of the Euphorbiaceae , 1994 .

[14]  D. Seigler Phytochemistry and Systematics of the Euphorbiaceae , 1994 .

[15]  P. W. Grosvenor,et al.  Medicinal plants from Riau province, Sumatra, Indonesia. Part 1: Uses. , 1995, Journal of ethnopharmacology.

[16]  W. Peumans,et al.  Lectins as Plant Defense Proteins , 1995, Plant physiology.

[17]  C. Moretti,et al.  Antiprotozoal activity of Jatrogrossidione from Jatropha grossidentata and Jatrophone from Jatropha isabellii , 1996 .

[18]  S. Mohamed,et al.  Antimycotic Screening of 58 Malaysian Plants against Plant Pathogens , 1996 .

[19]  H. Bohnert,et al.  Molecular Genetics of Crassulacean Acid Metabolism , 1997, Plant physiology.

[20]  A. Szallasi,et al.  Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine. , 1997, Life sciences.

[21]  C. Ukwe ANTIULCER ACTIVITY OF AQUEOUS STEMBARK EXTRACT OF HYMENOCARDIA ACIDA TUL (EUPHORBIACEAE) , 1997 .

[22]  J. Koricheva,et al.  Regulation of Woody Plant Secondary Metabolism by Resource Availability: Hypothesis Testing by Means of Meta-Analysis , 1998 .

[23]  Zhi-hong Xu,et al.  Casbane Diterpenoids from Euphorbia Ebracteolata , 1998 .

[24]  W. F. Zheng,et al.  Cytotoxicity and Antiviral Activity of the Compounds from Euphorbia kansui , 1998, Planta medica.

[25]  A. Agrawal,et al.  Dynamic anti-herbivore defense in ant-plants : the role of induced responses , 1998 .

[26]  C. Lovell Some biblical plants of dermatological importance. , 1998, Clinics in dermatology.

[27]  P. Cataluna,et al.  The traditional use of the latex from Euphorbia tirucalli Linnaeus (Euphorbiaceae) in the treatment of cancer in South Brazil , 1999 .

[28]  M. Trabi,et al.  Exploitation of the tropical oil seed plant Jatropha curcas L. , 1999 .

[29]  A. F. Dos Santos,et al.  Molluscicidal activity of the diterpenoids jatrophone and jatropholones A and B isolated fromJatropha elliptica (Pohl) Muell. Arg. , 1999, Phytotherapy research : PTR.

[30]  J. Chiou,et al.  Antiviral tannins from two Phyllanthus species. , 1999, Planta medica.

[31]  A. F. Dos Santos,et al.  Molluscicidal activity of the diterpenoids jatrophone and jatropholones A and B isolated from Jatropha elliptica (Pohl) Muell. Arg. , 1999, Phytotherapy research : PTR.

[32]  G. Vogg,et al.  Tumor promoting diterpenes from Euphorbia leuconeura L. , 1999, Phytochemistry.

[33]  B. Akendengué,et al.  Recent advances in the fight against leishmaniasis with natural products. , 1999, Parasite.

[34]  A. Borland,et al.  Metabolite Control Overrides Circadian Regulation of Phosphoenolpyruvate Carboxylase Kinase and CO(2) Fixation in Crassulacean Acid Metabolism. , 1999, Plant physiology.

[35]  B. Halkier,et al.  Substrate specificity of the cytochrome P450 enzymes CYP79A1 and CYP71E1 involved in the biosynthesis of the cyanogenic glucoside dhurrin in Sorghum bicolor (L.) Moench. , 1999, Archives of biochemistry and biophysics.

[36]  V. Prachayasittikul,et al.  Constituents and bioactivity of the tubers of Euphorbia sessiliflora. , 2000, Phytochemistry.

[37]  L. S. Devi,et al.  Evaluation of some plant latices against Heterodera cajani on cowpea (Vigna sinensis). , 2000 .

[38]  W. Palatnick,et al.  Hepatotoxicity from Castor Bean Ingestion in a Child , 2000, Journal of toxicology. Clinical toxicology.

[39]  P. Proost,et al.  Isolation and characterization of a jacalin-related mannose-binding lectin from salt-stressed rice (Oryza sativa) plants , 2000, Planta.

[40]  M. Kluge,et al.  Implications of Genotypic Diversity and Phenotypic Plasticity in the Ecophysiological Success of CAM Plants, Examined by Studies on the Vegetation of Madagascar , 2001 .

[41]  E. Hwang,et al.  Inhibitory activity for chitin synthase II from Saccharomyces cerevisiae by tannins and related compounds. , 2004, Planta medica.

[42]  P. Damme Euphorbia Tirucalli for High Biomass Production , 2001 .

[43]  T. Konoshima,et al.  Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha. II. , 2001, Biological & pharmaceutical bulletin.

[44]  G. Appendino,et al.  Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway. , 2001, Chemistry & biology.

[45]  G. Piéroni,et al.  Lipolytic activity of ricin from Ricinus sanguineus and Ricinus communis on neutral lipids. , 2001, The Biochemical journal.

[46]  C. Hiruma-Lima,et al.  Natural trans-crotonin: the antiulcerogenic effect of another diterpene isolated from the bark of Croton cajucara Benth. , 2002, Biological & pharmaceutical bulletin.

[47]  Maria-José U. Ferreira,et al.  Study of the Methanol Extract of Euphorbia segetalis , 2002 .

[48]  Hideyuki Ito,et al.  Accumulation of hydrolyzable tannins by Aleurites fordii callus culture. , 2002, Planta medica.

[49]  S. Abdelgaleil,et al.  Molluscicidal and anti-feedant activities of diterpenes from Euphorbia paralias L. , 2002, Pest management science.

[50]  J. E. Forero,et al.  Cytotoxic and antiviral activities of Colombian medicinal plant extracts of the Euphorbia genus. , 2002, Memorias do Instituto Oswaldo Cruz.

[51]  F. Hadacek Secondary Metabolites as Plant Traits: Current Assessment and Future Perspectives , 2002 .

[52]  S. Goerdt,et al.  [Allergic reaction after contact with Hura crepitans (sandbox tree)]. , 2002, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

[53]  Chun-ching Lin,et al.  Antioxidant and antiviral activities of Euphorbia thymifolia L. , 2002, Journal of biomedical science.

[54]  M. Pérez-Amador,et al.  Essential oil in leaves of Croton pseudoniveus & C suberosus (Euphorbiaceae) species (with 3 tables) , 2003 .

[55]  M. Wink Evolution of secondary metabolites from an ecological and molecular phylogenetic perspective. , 2003, Phytochemistry.

[56]  M. C. de Vasconcellos,et al.  Activity of Euphorbia splendens var. hislopii N.E.B. (Euphorbiaceae) latex against Lymnaea columella (Say, 1817) (Pulmonata: Lymnaeidae), intermediate host of Fasciola hepatica, Linnaeus, 1758 (Trematoda: Fasciolidae). 2: limited field-testing. , 2003, Memorias do Instituto Oswaldo Cruz.

[57]  R. Gambari,et al.  Evaluation of the mutagenic, antimutagenic and antiproliferative potential of Croton lechleri (Muell. Arg.) latex. , 2003, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[58]  M. Vasconcellos,et al.  Activity of Euphorbia splendens var. hislopii N.E.B. (Euphorbiaceae) Latex against Lymnaea columella (Say, 1817) (Pulmonata: Lymnaeidae), Intermediate Host of Fasciola hepatica, Linnaeus, 1758 (Trematoda: Fasciolidae). 2: Limited Field-testing , 2003 .

[59]  R. Bressan,et al.  In Defense against Pathogens. Both Plant Sentinels and Foot Soldiers Need to Know the Enemy1,212 , 2003, Plant Physiology.

[60]  D. Njamen,et al.  Anti-inflammatory and Analgesic Effects of Drypemolundein A, a Sesquiterpene Lactone from Drypetes molunduana , 2003 .

[61]  M. Lerdau,et al.  The Evolution of Function in Plant Secondary Metabolites , 2003, International Journal of Plant Sciences.

[62]  Shripad M Upasani,et al.  Partial characterization and insecticidal properties of Ricinus communis L foliage flavonoids. , 2003, Pest management science.

[63]  I. Khan,et al.  Antifungal clerodane diterpenes from Macaranga monandra (L) Muell. et Arg. (Euphorbiaceae). , 2003, Journal of agricultural and food chemistry.

[64]  A. Elujoba,et al.  TRADITIONAL MEDICINE DEVELOPMENT FOR MEDICAL AND DENTAL PRIMARY HEALTH CARE DELIVERY SYSTEM IN AFRICA. , 2004 .

[65]  U. Lüttge Ecophysiology of Crassulacean Acid Metabolism (CAM). , 2004, Annals of botany.

[66]  Maria-José U. Ferreira,et al.  Bioactive diterpenoids, a new jatrophane and two ent-abietanes, and other constituents from Euphorbia pubescens. , 2004, Journal of natural products.

[67]  F. Arvelo,et al.  Three new Glutarimide Alkaloids from Croton Cuneatus , 2004, Natural product research.

[68]  A. Borland,et al.  Synchronization of metabolic processes in plants with Crassulacean acid metabolism. , 2004, Journal of experimental botany.

[69]  O. Bueno,et al.  Activity of Ricinus communis (Euphorbiaceae) and ricinine against the leaf-cutting ant Atta sexdens rubropilosa (Hymenoptera: Formicidae) and the symbiotic fungus Leucoagaricus gongylophorus. , 2004, Pest management science.

[70]  J. Annapurna,et al.  Antimicrobial Activity of Euphorbia nivulia Leaf Extract , 2004 .

[71]  H. Duddeck,et al.  Chemical Composition and Antitumor Activities from Givotia madagascariensis. , 2004 .

[72]  J. Eloff,et al.  Isolation, characterisation and antifungal activity of β-1,3-glucanase from seeds of Jatropha curcas , 2005 .

[73]  P. Di Meglio,et al.  Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent. , 2005, Journal of medicinal chemistry.

[74]  M. Chase,et al.  Molecular phylogenetic analysis of uniovulate Euphorbiaceae (Euphorbiaceae sensu stricto) using plastid RBCL and TRNL-F DNA sequences. , 2005, American journal of botany.

[75]  A. Adedapo,et al.  Anthelmintic efficacy of the aqueous crude extract of Euphorbia hirta Linn in Nigerian dogs , 2005 .

[76]  F. Yu,et al.  Isolation and characterization of methyl esters and derivatives from Euphorbia kansui (Euphorbiaceae) and their inhibitory effects on the human SGC-7901 cells. , 2005, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[77]  Naveen Kumar,et al.  Jatropha curcus ─ A sustainable source for production of biodiesel , 2005 .

[78]  K. Adebowale Chemical composition and insecticidal properties of the underutilized Jatropha curcas seed oil , 2006 .

[79]  Z. Zakaria,et al.  The in vitro Antibacterial Activity and Brine Shrimp Toxicity of Manihot esculenta var. Sri Pontian (Euphorbiacea) Extracts , 2006 .

[80]  P. Bessong,et al.  Further screening of Venda medicinal plants for activity against HIV type 1 reverse transcriptase and integrase , 2006 .

[81]  I. Baloch,et al.  Cytotoxic macrocyclic diterpenoid esters from Euphorbia cornigera. , 2006, Planta medica.

[82]  P. Bruyns,et al.  A new subgeneric classification for Euphorbia (Euphorbiaceae) in southern Africa based on ITS and psbA-trnH sequence data , 2006 .

[83]  A. Barla,et al.  Secondary Metabolites from Euphorbia helioscopia and Their Vasodepressor Activity , 2006 .

[84]  I. Ahmad,et al.  Modern phytomedicine: Turning Medicinal Plants into Drugs , 2006 .

[85]  J. Toler,et al.  Suppressing Sting Nematodes with Brassica sp., Poinsettia, and Spotted Spurge Extracts , 2006 .

[86]  H. Tobe,et al.  Embryology and systematics of Euphorbiaceaesens. lat.: a review and perspective , 1995, Journal of Plant Research.

[87]  R. Bussmann,et al.  Journal of Ethnobiology and Ethnomedicine Open Access Traditional Medicinal Plant Use in Loja Province, Southern Ecuador , 2022 .

[88]  Nzigamasabo Aloys,et al.  Traditional Cassava Foods in Burundi—A Review , 2006 .

[89]  A. F. Dos Santos,et al.  The lethality of Euphorbia conspicua to adults of Biomphalaria glabrata, cercaria of Schistosoma mansoni and larvae of Artemia salina. , 2007, Bioresource technology.

[90]  Pedro Benjumea,et al.  El biodiesel de aceite de higuerilla como combustible alternativo para motores diesel , 2007 .

[91]  B. Gupta,et al.  Therapeutic uses of Euphorbia thymifolia: A review , 2007 .

[92]  E. Pretorius,et al.  Asthma, Euphorbia hirta and its anti-inflammatory properties , 2007 .

[93]  S. Meneghetti,et al.  Biodiesel Production from Vegetable Oil Mixtures: Cottonseed, Soybean, and Castor Oils , 2007 .

[94]  G. Mcpherson,et al.  REVISION OF WIELANDIA, INCLUDING BLOTIA AND PETALODISCUS (PHYLLANTHACEAE; EUPHORBIACEAE S.L.)1 , 2007 .

[95]  P. Abreu,et al.  Antimalarial Flavonol Glycosides from Euphorbia hirta. , 2007 .

[96]  R. Bukenya-Ziraba,et al.  An inventory of medicinal plants used in treating poultry diseases in Jinja district, eastern Uganda , 2007 .

[97]  T. Srinivas Industrial Demand for Cassava Starch in India , 2007 .

[98]  I. C. Okoli,et al.  Antibacterial activities and toxicological potentials of crude ethanolic extracts of Euphorbia hirta , 2007 .

[99]  J. Wandji,et al.  Antileishmanial furanosesquiterpene and triterpenoids from Drypetes chevalieri Beille (Euphorbiaceae) Furanosesquiterpenos y Triterpenoides de Drypetes chevalieri Beille (Euphorbiaceae) con actividad antileismania. , 2007 .

[100]  K. Ogunwenmo,et al.  Cultivars of Codiaeum variegatum (L.) Blume ( Euphorbiaceae ) show variability in phytochemical and cytological characteristics , 2007 .

[101]  A. Abdulkareem,et al.  Ethanol Fuel Production from Cassava as a Substitute for Gasoline , 2007 .

[102]  A. El-Bassuony Antibacterial Activity of New Polyester Diterpenes from Euphorbia guyoniana , 2007 .

[103]  Hong-ping He,et al.  Bioactive phenols from the leaves of Baccaurea ramiflora. , 2007, Planta medica.

[104]  U. Lüttge Stem CAM in arborescent succulents , 2008, Trees.

[105]  K. Becker,et al.  Phorbol Esters: Structure, Biological Activity, and Toxicity in Animals , 2007, International journal of toxicology.

[106]  Minoru Izumi,et al.  Three Antinematodal Diterpenes from Euphorbia kansui , 2007, Bioscience, biotechnology, and biochemistry.

[107]  C. Davis,et al.  Floral Gigantism in Rafflesiaceae , 2007, Science.

[108]  Toru Tokuoka Molecular phylogenetic analysis of Euphorbiaceae sensu stricto based on plastid and nuclear DNA sequences and ovule and seed character evolution , 2007, Journal of Plant Research.

[109]  I. Dalcol,et al.  Alkaloids from Melochia chamaedrys. , 2007, Planta medica.

[110]  P. Chabert,et al.  Antiplasmodial Activity of Constituents Isolated from Croton lobatus. , 2007 .

[111]  K. Wilson,et al.  Catalysts in Production of Biodiesel: A Review , 2007 .

[112]  J. Kasenene,et al.  Medicinal plant diversity and uses in the Sango bay area, Southern Uganda. , 2007, Journal of ethnopharmacology.

[113]  Dilsia J. Canelón,et al.  New Antiinflammatory Cycloart-23-ene-3β-ol from Senefelderopsis Chibiriquetensis , 2008 .

[114]  A. Figueiredo,et al.  Factors affecting secondary metabolite production in plants: volatile components and essential oils , 2008 .

[115]  Bin Li,et al.  Antibacterial activity of chitosan solution against Xanthomonas pathogenic bacteria isolated from Euphorbia pulcherrima , 2008 .

[116]  Sajjad Ali,et al.  Phytochemical and biological investigation of chloroform and ethylacetate fractions of Euphorbia heterophylla leaf (Euphorbiaceae) , 2008 .

[117]  Maria-José U. Ferreira,et al.  Three new jatrophane polyesters and antiproliferative constituents from Euphorbia tuckeyana. , 2008, Planta medica.

[118]  O. Sticher,et al.  Medical ethnobotany of the Yucatec Maya: Healers’ consensus as a quantitative criterion , 1999, Economic Botany.

[119]  Pankaj,et al.  Nematicidal prenylated flavanones from Phyllanthus niruri. , 2008, Phytochemistry.

[120]  H. Griffiths,et al.  Leaf succulence determines the interplay between carboxylase systems and light use during Crassulacean acid metabolism in Kalanchöe species. , 2008, Journal of experimental botany.

[121]  Minoru Izumi,et al.  Antinematodal Activities of Ingenane Diterpenes from Euphorbia kansui and their Derivatives against the Pine Wood Nematode (Bursaphelenchus xylophilus) , 2008, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[122]  R. Dahiya Synthesis and in vitro cytotoxic activity of a natural peptide of plant origin , 2008 .

[123]  N. Lall,et al.  Antibacterial activities and cytotoxicity of terpenoids isolated from Spirostachys africana. , 2008, Journal of ethnopharmacology.

[124]  E. Barile,et al.  Diterpenes from Euphorbia as Potential Leads for Drug Design , 2008 .

[125]  I. Dalcol,et al.  Quinolone alkaloids from Waltheria douradinha. , 2008, Phytochemistry.

[126]  L. Verchot,et al.  Jatropha bio-diesel production and use , 2008 .

[127]  E. Damme Plant Lectins as Part of the Plant Defense System Against Insects , 2008 .

[128]  A. Schaller Induced plant resistance to herbivory , 2008 .

[129]  O. Aiyelaagbe,et al.  Antibacterial Diterpenoids from Jatropha podagrica Hook. , 2008 .

[130]  G. Shlamovitz,et al.  A case of acute keratoconjunctivitis from exposure to latex of Euphorbia tirucalli (pencil cactus). , 2009, The Journal of emergency medicine.

[131]  E. Aschehoug,et al.  Plant behavioural ecology: dynamic plasticity in secondary metabolites. , 2009, Plant, cell & environment.

[132]  H. Ceballos,et al.  Screening of Starch Quality Traits in Cassava (Manihot esculenta Crantz) , 2009 .

[133]  N. Martínez,et al.  SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro. , 2009, Biochemical pharmacology.

[134]  J. Wandji,et al.  Triterpenoids with antimicrobial activity from Drypetes inaequalis. , 2009, Phytochemistry.

[135]  R. Okigbo,et al.  Advances in selected medicinal and aromatic plants indigenous to Africa. , 2009 .

[136]  A. Herrera Crassulacean acid metabolism and fitness under water deficit stress: if not for carbon gain, what is facultative CAM good for? , 2009, Annals of botany.

[137]  Hee-kyoung Kang,et al.  New triterpenoid saponins from Glochidion eriocarpum and their cytotoxic activity. , 2009, Chemical & pharmaceutical bulletin.

[138]  S. Meneghetti,et al.  Characteristics and composition of Jatropha gossypiifolia and Jatropha curcas L. oils and application for biodiesel production , 2009 .

[139]  Xumin Lai,et al.  The investigation of Euphorbiaceous medicinal plants in Southern China , 2004, Economic Botany.

[140]  M. Zatloukal,et al.  Experimental investigation of flow induced molecular weight fractionation phenomenon for two linear HDPE polymer melts having same Mn and Mw but different Mz and Mz+1 average molecular weights , 2012 .