Studies on the nature and genetic control of an antigen in normal chick embryos which reacts in the COFAL test.

Summary Chick embryos from the inbred Reaseheath I line of chickens contained a complement-fixing antigen which reacted in the COFAL test, whereas embryos from the inbred Reaseheath C line lacked the antigen. In cross-bred embryos between the I and C lines the antigen segregated in accordance with the hypothesis that the presence of the antigen was controlled by a single autosomal dominant gene. The antigen appeared to be identical to the group-specific antigen of the avian leukosis-sarcoma group of viruses. No infectious virus was detected in I-line embryos, and the presence of the antigen was not correlated with response to the A and B subgroups of avian leukosis-sarcoma viruses. The possible relationship between the I-line antigen and viral group-specific antigen is discussed.

[1]  A. Beale,et al.  The complement-fixation test for avian leukosis. , 1968, The Journal of general virology.

[2]  L. N. Payne,et al.  Influence of host genotype on responses to four strains of avian leukosis virus. , 1968, Journal of the National Cancer Institute.

[3]  H. Bauer,et al.  Group-specific antigen of avian leukosis viruses. Virus specificity and relation to an antigen contained in Rous mammalian tumor cells. , 1967, Virology.

[4]  W. Okazaki,et al.  Two Loci Controlling Genetic Cellular Resistance to Avian Leukosis-Sarcoma Viruses , 1967, Journal of virology.

[5]  P. Vogt A virus released by "nonproducing" Rous sarcoma cells. , 1967, Proceedings of the National Academy of Sciences of the United States of America.

[6]  F. Roth,et al.  Virus particles and viral antigens in chicken tissues free of infectious avian leukosis virus. , 1967, Proceedings of the National Academy of Sciences of the United States of America.

[7]  R. Weiss Spontaneous virus production from "non-virus producing" Rous sarcoma cells. , 1967, Virology.

[8]  L. N. Payne,et al.  Studies on Marek's disease. I. Experimental transmission. , 1967, Journal of the National Cancer Institute.

[9]  Stanfield Rogers Shope Papilloma Virus: A Passenger in Man and its Significance to the Potential Control of the Host Genome , 1966, Nature.

[10]  R. M. Dougherty,et al.  Lack of relationship between infection with avian leukosis virus and the presence of COFAL antigen in chick embryos. , 1966, Virology.

[11]  D. Bailey HERITABLE HISTOCOMPATIBILITY CHANGES: LYSOGENY IN MICE? , 1966, Transplantation.

[12]  H. Bauer,et al.  Origin of group-specific antigen of chicken leukosis viruses. , 1966, Virology.

[13]  L. N. Payne,et al.  Genetic basis of cellular susceptibility to the Schmidt-Ruppin and Harris strains of Rous sarcoma virus. , 1966, Virology.

[14]  W. T. Lane,et al.  Complement-Fixing Antigens in Hamster Tumors Induced by the Bryan Strain of Rous Sarcoma Virus , 1966, Science.

[15]  H. Temin Genetic and possible biochemical mechanisms in viral carcinogenesis. , 1966, Cancer research.

[16]  P. Vogt,et al.  Reciprocal patterns of genetic resistance to avian tumor viruses in two lines of chickens. , 1965, Virology.

[17]  H. Rubin GENETIC CONTROL OF CELLULAR SUSCEPTIBILITY TO PSEUDOTYPES OF ROUS SARCOMA VIRUS. , 1965, Virology.

[18]  L. N. Payne,et al.  DIFFERENCES BETWEEN HIGHLY INBRED LINES OF CHICKENS IN THE RESPONSE TO ROUS SARCOMA VIRUS OF THE CHORIOALLANTOIC MEMBRANE AND OF EMBRYONIC CELLS IN TISSUE CULTURE. , 1964, Virology.

[19]  R. Rott,et al.  STUDIES ON THE BAI STRAIN A (AVIAN MYELOBLASTOSIS) VIRUS. I. PRODUCTION AND EXAMINATION OF POTENT VIRUS-SPECIFIC COMPLEMENT-FIXING ANTISERA. , 1964, Virology.

[20]  R. Huebner,et al.  AN AVIAN LEUCOSIS GROUP-SPECIFIC COMPLEMENT FIXATION REACTION. APPLICATION FOR THE DETECTION AND ASSAY OF NON-CYTOPATHOGENIC LEUCOSIS VIRUSES. , 1964, Virology.

[21]  R. Huebner,et al.  SPECIFIC COMPLEMENT-FIXING VIRAL ANTIGENS IN HAMSTER AND GUINEA PIG TUMORS INDUCED BY THE SCHMIDT-RUPPIN STRAIN OF AVIAN SARCOMA. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[22]  W. T. Lane,et al.  SPECIFIC ADENOVIRUS COMPLEMENT-FIXING ANTIGENS IN VIRUS-FREE HAMSTER AND RAT TUMORS. , 1963, Proceedings of the National Academy of Sciences of the United States of America.

[23]  R. M. Dougherty,et al.  The sensitivity of Rous sarcoma virus assays , 1962 .

[24]  H. Rubin,et al.  Tolerance and immunity in chickens after congenital and contact infection with an avian leukosis virus. , 1962, Virology.

[25]  H. Temin,et al.  Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture. , 1958, Virology.

[26]  J. G. Carr,et al.  Three New Virus-Induced Fowl Sarcomata , 1958, British Journal of Cancer.

[27]  J. Moloney Biological studies on the Rous sarcoma virus. V. Preparation of improved standard lots of the virus for use in quantitative investigations. , 1956, Journal of the National Cancer Institute.

[28]  Prince Am The biology of avian tumor viruses with especial emphasis on forms of virus: cell integration and the neoplastic nature of tumors induced by these agents. , 1966 .

[29]  A. Prince The biology of avian tumor viruses with especial emphasis on forms of virus: cell integration and the neoplastic nature of tumors induced by these agents. , 1966, Neoplasma.

[30]  L. N. Payne,et al.  Relationship of Marek's disease (neural lymphomatosis) to lymphoid leukosis. , 1964 .