An Efficient Blood Vessel Detection Algorithm For Retinal Images Using Local Entropy Thresholding

Diabetic retinopathy is one of the serious eye diseases that can cause blindness and vision loss. Diabetes mellitus, a metabolic disorder, has become one of the rapidly increasing health threats both in India and worldwide. The complication of the diabetes associated to retina of the eye is diabetic retinopathy. A patient with the disease has to undergo periodic screening of eye. For the diagnosis, ophthalmologists use color retinal images of a patient acquired from digital fundus camera. The present study is aimed at developing an automatic system for the extraction of normal and abnormal features in color retinal images. Prolonged diabetes causes micro-vascular leakage and micro-vascular blockage within the retinal blood vessels. Filter based approach with morphological filters is used to segment the vessels. The morphological filter are tuned to match that part of vessel to be extracted in a green channel image. To classify the pixels into vessels and non vessels local thresholding based on gray level co-occurrence matrix is applied. The performance of the method is evaluated on two publicly available retinal databases with hand labeled ground truths. The performance of retinal vessels on drive database, sensitivity 86.39%, accompanied by specificity of 91.2%. While for STARE database proposed method sensitivity 92.15 % and specificity 84.46%. The system could assist the ophthalmologists, to detect the signs of diabetic retinopathy in the early stage, for a better treatment plan and to improve the vision related quality of life. Keywords— Vessel segmentation, Morphological filter, Image Processing, Diabetic Retinopathy .

[1]  M. Goldbaum,et al.  Detection of blood vessels in retinal images using two-dimensional matched filters. , 1989, IEEE transactions on medical imaging.

[2]  Stanley Mirsky,et al.  Screening for diabetic retinopathy , 2003, The Lancet.

[3]  Yoshinobu Sato,et al.  Orientation Space Filtering for Multiple Orientation Line Segmentation , 2000, IEEE Trans. Pattern Anal. Mach. Intell..

[4]  Peter F. Sharp,et al.  Structural analysis of retinal vessels , 1997 .

[5]  Guoliang Fan,et al.  An efficient algorithm for extraction of anatomical structures in retinal images , 2003, Proceedings 2003 International Conference on Image Processing (Cat. No.03CH37429).

[6]  Alireza Osareh,et al.  Automated identification of diabetic retinal exudates and the optic disc , 2004 .

[7]  P. D. Thouin,et al.  Survey and comparative analysis of entropy and relative entropy thresholding techniques , 2006 .

[8]  T. Sano,et al.  [Diabetic retinopathy]. , 2001, Nihon rinsho. Japanese journal of clinical medicine.

[9]  Geoff Dougherty,et al.  Measurement of retinal vascular tortuosity and its application to retinal pathologies , 2009, Medical & Biological Engineering & Computing.

[10]  Hideki Kuga,et al.  A computer method of understanding ocular fundus images , 1982, Pattern Recognit..

[11]  C. Sinthanayothin,et al.  Automated detection of diabetic retinopathy on digital fundus images , 2002, Diabetic medicine : a journal of the British Diabetic Association.

[12]  Grading diabetic retinopathy from stereoscopic color fundus photographs--an extension of the modified Airlie House classification. ETDRS report number 10. Early Treatment Diabetic Retinopathy Study Research Group. , 1991, Ophthalmology.

[13]  Mong-Li Lee,et al.  An effective approach to detect lesions in color retinal images , 2000, Proceedings IEEE Conference on Computer Vision and Pattern Recognition. CVPR 2000 (Cat. No.PR00662).

[14]  Xiaohui Zhang,et al.  Top-down and bottom-up strategies in lesion detection of background diabetic retinopathy , 2005, 2005 IEEE Computer Society Conference on Computer Vision and Pattern Recognition (CVPR'05).

[15]  Yin Aye Moe,et al.  Automatic Exudate Detection with a Naive Bayes Classifier , 2008 .

[16]  Sushma G. Thorat Locating the Optic Nerve in a Retinal Image Using the Fuzzy Convergence of the Blood Vessels , 2014 .

[17]  Jeffrey E. Boyd,et al.  Automated diagnosis and image understanding with object extraction, object classification, and inferencing in retinal images , 1996, Proceedings of 3rd IEEE International Conference on Image Processing.

[18]  Mohammed Al-Rawi,et al.  An improved matched filter for blood vessel detection of digital retinal images , 2007, Comput. Biol. Medicine.

[19]  Langis Gagnon,et al.  Procedure to detect anatomical structures in optical fundus images , 2001, SPIE Medical Imaging.