论文信息 - Response to Letter Regarding Article, “Association of Cyclooxygenase-1–Dependent and –Independent Platelet Function Assays With Adverse Clinical Outcomes in Aspirin-Treated Patients Presenting for Cardiac Catheterization”

Response to Letter Regarding Article, “Association of Cyclooxygenase-1–Dependent and –Independent Platelet Function Assays With Adverse Clinical Outcomes in Aspirin-Treated Patients Presenting for Cardiac Catheterization”

Our conclusion that “poor clinical outcomes of aspirin-treated patients is due in part to incomplete cyclooxygenase-1 (COX-1) inhibition, but is also due in part to COX-1–independent platelet hyperreactivity” is based on the independent association of both high residual serum thromboxane B2 (TXB2) and shortened platelet function analyzer (PFA-100) collagen/ADP closure time (CADP CT; indicative of COX-1–independent platelet hyperreactivity) with adverse outcomes in aspirin-treated patients.1 These findings help define factors that contribute to the risk for adverse events in …

[1] S. Basili,et al. Letter by Violi et al regarding article, "Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization". , 2010, Circulation.

[2] M. Furman,et al. Residual Arachidonic Acid–Induced Platelet Activation via an Adenosine Diphosphate–Dependent but Cyclooxygenase-1– and Cyclooxygenase-2–Independent Pathway: A 700-Patient Study of Aspirin Resistance , 2006, Circulation.