Resisting Memory Storage: Activating Endogenous Protein Kinease C Inhibitors

We have recently proposed a model of long-term potentiation (LTP), a physiological model of memory storage in the brain, that has as its major theme the view that signal transduction mechanisms on both sides of the synapse leads to the enhanced synaptic communication of LTP (Colley and Routtenberg, 1992). This involves a sequence of events requiring bidirectional communication, the first signal being presynaptic transmitter release. A modified version of this model is shown in Figure 1. In the present chapter I will first review the model and then discuss the likely control points in the sequence and the synergistic relation between messengers and retrograde signals.

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