Adnexal Masses in Perimenopausal Women: How Effective is Color Flow Mapping and Pulse Doppler Waveform Studies in detecting Malignancy Preoperatively?

Objective: This prospective study was undertaken to assess the sensitivity and specificity of color flow mapping and pulse Doppler waveform in identifying malignancy preoperatively in adnexal masses in perimenopausal women. Materials and methods: A total of 100 cases with adnexal masses in perimenopausal women were scanned, underwent color flow mapping and pulsed Doppler waveform studies. These cysts were divided into three groups according to their ultrasound appearance – cystic, mixed cystic and solid. All the adnexal mases were removed surgically and sent for histopathological study. Results: The sensitivity and specificity of color flow mapping in identifying malignant ovarian tumors was 63.6 and 87.0% respectively. In the case of solid cysts, color flow mapping identified all malignant tumors. But, color flow mapping missed malignancies in cystic and mixed cystic masses. To improve detection rates, we used Doppler waveform studies and used resistance index less than 0.4 as the indicator of malignancy and found overall sensitivity and specificity of 90.9 and 92.3%, which was higher than that of color flow mapping. Conclusion: To conclude ultrasonic color flow mapping and pulse Doppler waveform studies used preoperatively on adnexal masses in perimenopausal women are widely available, performed rapidly and relatively easily, cost-effective and a reliable noninvasive method to predict malignancy preoperatively.

[1]  S. Naudé,et al.  The relevance of angiogenesis in benign and malignant epithelial tumors of the ovary: a quantitative histologic study. , 1997, Gynecologic oncology.

[2]  E. Ferrazzi,et al.  Transvaginal ultrasonographic characterization of ovarian masses: comparison of five scoring systems in a multicenter study , 1997, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[3]  F. Kikkawa,et al.  Antenatal Classification of Hydrops Fetalis , 1992 .

[4]  K. Jain Prospective evaluation of adnexal masses with endovaginal gray-scale and duplex and color Doppler US: correlation with pathologic findings. , 1994, Radiology.

[5]  R. Filly,et al.  Sonography of ovarian masses: poor sensitivity of resistive index for identifying malignant lesions. , 1994, AJR. American journal of roentgenology.

[6]  B. Bromley,et al.  Comparison Between Sonographic Morphology and Doppler Waveform for the Diagnosis of Ovarian Malignancy , 1994, Obstetrics and gynecology.

[7]  F. Ghezzi,et al.  Diagnosis of pelvic masses with transabdominal color Doppler, CA 125 and ultrasonography , 1995, Acta obstetricia et gynecologica Scandinavica.

[8]  A. Schneider,et al.  Comparison of Doppler with Two-Dimensional Sonography and CA 125 for Prediction of Malignancy of Pelvic Masses , 1993, Obstetrics and Gynecology.

[9]  D. Hanahan,et al.  Induction of angiogenesis during the transition from hyperplasia to neoplasia , 1989, Nature.

[10]  J. Scatarige,et al.  A prospective evaluation of transvaginal sonography for detection of ovarian disease. , 1993, AJR. American journal of roentgenology.

[11]  J. Folkman,et al.  ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS , 1971, The Journal of experimental medicine.

[12]  A. Kurjak,et al.  Evaluation of adnexal masses with transvaginal color ultrasound. , 1991, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[13]  A. Kurjak,et al.  Transvaginal Ultrasound, Color Flow, and Doppler Waveform of the Postmenopausal Adnexal Mass , 1992, Obstetrics and gynecology.

[14]  A. Reles,et al.  Transvaginal color Doppler sonography and conventional sonography in the preoperative assessment of adnexal masses , 1997, Journal of clinical ultrasound : JCU.

[15]  P. Doubilet,et al.  Ovarian Masses: Can Benign and Malignant Lesions be Differentiated with Color and Pulsed Doppler US? , 1994, Radiology.

[16]  Z. Weiner,et al.  Transvaginal sonography, color flow imaging, computed tomographic scanning, and CA 125 as a routine follow‐up examination in women with pelvic tumor: detection of recurrent disease. , 1994, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[17]  F. Miller,et al.  Benign and malignant ovarian masses: selection of the most discriminating gray-scale and Doppler sonographic features. , 1998, Radiology.

[18]  Transvaginal Sonography: Comparison with Transabdominal Sonography in the Diagnosis of Pelvic Masses , 1988 .

[19]  B. Śpiewankiewicz,et al.  Preoperative discrimination between malignant and benign adnexal masses with transvaginal ultrasonography and colour blood flow imaging. , 2001, European journal of gynaecological oncology.

[20]  J. Alcázar,et al.  Three‐Dimensional Power Doppler Vascular Sampling , 2005, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[21]  J. Kotarski,et al.  [The use of 2-dimensional and 3-dimensional color and power-Doppler in the diagnosis of blood flow indices of adnexal tumors]. , 2006, Ginekologia polska.

[22]  K. Sugimura,et al.  A critical evaluation of transvaginal Doppler studies, transvaginal sonography, magnetic resonance imaging, and CA 125 in detecting ovarian cancer , 1992, Obstetrics and gynecology.

[23]  J. Pellerito,et al.  Common pitfalls of endovaginal color Doppler flow imaging. , 1995, Radiographics : a review publication of the Radiological Society of North America, Inc.

[24]  L. White,et al.  Doppler sonography of adnexal masses: the predictive value of the pulsatility index in benign and malignant disease. , 1994, AJR. American journal of roentgenology.

[25]  J. Tyszka,et al.  Differentiation of benign and malignant adnexal masses: relative value of gray-scale, color Doppler, and spectral Doppler sonography. , 1995, AJR. American journal of roentgenology.

[26]  L. Twiggs,et al.  Flow Characteristics in Benign and Malignant Gynecologic Tumors Using Transvaginal Color Flow Doppler , 1994, Obstetrics and gynecology.

[27]  A. Goldhirsch,et al.  Sonographic Patterns of Ovarian Tumors: Prediction of Malignancy , 1987, Obstetrics and gynecology.

[28]  S Goldberger,et al.  Transvaginal sonographic characterization of ovarian disease: evaluation of a new scoring system to predict ovarian malignancy. , 1991, Obstetrics and gynecology.

[29]  E. Andolf,et al.  A Prospective Comparison of Transabdominal and Transvaginal Ultrasound with Surgical Findings in Gynecologic Disease , 1990, Journal of ultrasound in medicine.

[30]  A. Lissoni,et al.  Color Doppler ultrasound in the preoperative assessment of adnexal masses , 1994, Acta obstetricia et gynecologica Scandinavica.

[31]  T. Bourne,et al.  Screening for ovarian cancer by transvaginal sonography and colour Doppler. , 1993, European journal of obstetrics, gynecology, and reproductive biology.

[32]  T. Hata,et al.  Doppler ultrasound assessment of tumor vascularity in gynecologic disorders. , 1989, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[33]  E. Andolf,et al.  A prospective comparison of clinical ultrasound and operative examination of the female pelvis. , 1988, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[34]  T. Kawarabayashi,et al.  Differences in the angiogenesis of benign and malignant ovarian tumors, demonstrated by analyses of color doppler ultrasound, immunohistochemistry, and microvessel density , 1997, Cancer.

[35]  F Tranquart,et al.  Power Doppler vascularity index for predicting malignancy of adnexal masses , 2005, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[36]  K. Eibenberger,et al.  Tumor vascularization: assessment with duplex sonography. , 1991, Radiology.

[37]  J. Itskovitz‐Eldor,et al.  Assessment of ovarian and uterine blood flow by transvaginal color Doppler in ovarian-stimulated women: correlation with the number of follicles and steroid hormone levels. , 1993, Fertility and sterility.

[38]  I. Timor-Tritsch,et al.  Transvaginal ultrasonographic characterization of ovarian masses with an improved, weighted scoring system. , 1994, American journal of obstetrics and gynecology.

[39]  A. Kurjak,et al.  Transvaginal color and pulsed Doppler assessment of adnexal tumor vascularity. , 1993, Gynecologic oncology.

[40]  A. Rempen,et al.  Transvaginal ultrasonography of pelvic masses: evaluation of B-mode technique and Doppler ultrasonography. , 1996, American journal of obstetrics and gynecology.

[41]  A. Kurjak,et al.  New scoring system for prediction of ovarian malignancy based on transvaginal color Doppler sonography. , 1993, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[42]  I. Timor-Tritsch,et al.  Transvaginal ultrasonographic characterization of ovarian masses by means of color flow‐directed Doppler measurements and a morphologic scoring system , 1993, American journal of obstetrics and gynecology.

[43]  J. Deutinger,et al.  Localization of Blood Vessels and Qualitative Assessment of Blood Flow in Ovarian Tumors , 1995, Obstetrics and gynecology.

[44]  D. Grimes,et al.  Relative frequency of primary ovarian neoplasms: A 10‐year review , 1989, Obstetrics and gynecology.