Valproic acid induced liver injury: An insight into molecular toxicological mechanism.
暂无分享,去创建一个
[1] Weifeng Huang,et al. Mitochondrial stress response in drug-induced liver injury , 2021, Molecular Biology Reports.
[2] S. Bolkent,et al. Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis , 2021, Toxicology mechanisms and methods.
[3] H. Jaeschke,et al. Mitochondrial Dynamics in Drug-Induced Liver Injury , 2021, Livers.
[4] K. Ouguerram,et al. Epigenetic Regulation of Peroxisome Proliferator-Activated Receptor Gamma Mediates High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease , 2021, Cells.
[5] H. Kalantari,et al. Taurine attenuates valproic acid-induced hepatotoxicity via modulation of RIPK1/RIPK3/MLKL-mediated necroptosis signaling in mice , 2021, Molecular Biology Reports.
[6] D. Ezhilarasan. Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases: Mitochondria in hepatic stellate cells. , 2021, Hepatobiliary & pancreatic diseases international : HBPD INT.
[7] Elias Adikwu,et al. Valporic acid-induced hepatotoxicity in rats: Protective effect of selenium , 2021 .
[8] H. Parlakpınar,et al. Protective effects of naringin on valproic acid-induced hepatotoxicity in rats. , 2021, Tissue & cell.
[9] J. Uetrecht,et al. Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges , 2021, International journal of molecular sciences.
[10] A. Borobia,et al. Valproic Acid-Induced Liver Injury: A Case-Control Study from a Prospective Pharmacovigilance Program in a Tertiary Hospital , 2021, Journal of clinical medicine.
[11] R. Teschke,et al. Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues , 2020, Annals of translational medicine.
[12] D. Gharib,et al. Antioxidant and anti-inflammatory properties of alpha lipoic acid protect against valproic acid induced liver injury. , 2020, Canadian journal of physiology and pharmacology.
[13] Guangchun Sun,et al. Valproic acid reverses sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in hepatocellular carcinoma , 2020, Fundamental & clinical pharmacology.
[14] Yingjie Guo,et al. Involvement of CYP2E1-ROS-CD36/DGAT2 axis in the pathogenesis of VPA-induced hepatic steatosis in vivo and in vitro. , 2020, Toxicology.
[15] T. Yokoi,et al. Models of Idiosyncratic Drug-Induced Liver Injury. , 2020, Annual review of pharmacology and toxicology.
[16] M. Hüttemann,et al. Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae , 2020, Scientific Reports.
[17] J. Kleinjans,et al. Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression , 2020, Archives of Toxicology.
[18] Hongliang Li,et al. Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease. , 2020, Free radical biology & medicine.
[19] Po-Chen Lin,et al. Valproic Acid-Induced Hyperammonemic Encephalopathy in a Patient with Bipolar Disorder: A Case Report , 2020, Brain sciences.
[20] Sophia L. Samodelov,et al. Obeticholic Acid Ameliorates Valproic Acid–Induced Hepatic Steatosis and Oxidative Stress , 2020, Molecular Pharmacology.
[21] Amany M Gad,et al. Ellagic acid attenuates liver toxicity induced by valproic acid in rats. , 2020, Journal of pharmacological sciences.
[22] R. Citraro,et al. Butyrate prevents valproate‐induced liver injury: In vitro and in vivo evidence , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[23] Jie Sun,et al. Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer , 2020, The FEBS journal.
[24] C. Shan,et al. Metabolomics reveals the effect of valproic acid on MCF-7 and MDA-MB-231 cells , 2020, Xenobiotica; the fate of foreign compounds in biological systems.
[25] D. Larrey,et al. Drug-Induced Liver Injury: Biomarkers, Requirements, Candidates, and Validation , 2019, Front. Pharmacol..
[26] Xiang-chang Zeng,et al. Ginsenoside compound K alleviates sodium valproate-induced hepatotoxicity in rats via antioxidant effect, regulation of peroxisome pathway and iron homeostasis. , 2019, Toxicology and applied pharmacology.
[27] M. Uzun,et al. Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats , 2019, Molecular Biology Reports.
[28] Limei Zhao,et al. Lipidomic Profiling Reveals Disruption of Lipid Metabolism in Valproic Acid-Induced Hepatotoxicity , 2019, Front. Pharmacol..
[29] E. Björnsson,et al. Drug-Induced Liver Injury - Types and Phenotypes. , 2019, The New England journal of medicine.
[30] Rongsheng Tong,et al. RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review) , 2019, International journal of molecular medicine.
[31] J. Lykkesfeldt,et al. A role of peroxisome proliferator‐activated receptor γ in non‐alcoholic fatty liver disease , 2019, Basic & clinical pharmacology & toxicology.
[32] D. Scolnik,et al. Levocarnitine for the Treatment of Valproic Acid–Induced Hyperammonemic Encephalopathy in Children: The Experience of a Large, Tertiary Care Pediatric Hospital and a Poison Center , 2017, American journal of therapeutics.
[33] Xiao-peng Lu,et al. Valproic Acid and the Liver Injury in Patients with Epilepsy: An Update. , 2019, Current pharmaceutical design.
[34] J. Park,et al. Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2☆ , 2018, Liver research.
[35] R. Teschke. Top-ranking drugs out of 3312 drug-induced liver injury cases evaluated by the Roussel Uclaf Causality Assessment Method , 2018, Expert opinion on drug metabolism & toxicology.
[36] N. Ahmed,et al. Agmatine protects against sodium valproate–induced hepatic injury in mice via modulation of nuclear factor‐κB/inducible nitric oxide synthetase pathway , 2018, Journal of biochemical and molecular toxicology.
[37] Vijay Gayam,et al. Valproic acid induced acute liver injury resulting in hepatic encephalopathy- a case report and literature review , 2018, Journal of community hospital internal medicine perspectives.
[38] J. Kleinjans,et al. Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. , 2018, Toxicology letters.
[39] E. Zoidis,et al. Selenium-Dependent Antioxidant Enzymes: Actions and Properties of Selenoproteins , 2018, Antioxidants.
[40] Janthima Methaneethorn. A systematic review of population pharmacokinetics of valproic acid , 2018, British journal of clinical pharmacology.
[41] Kosuke Saito,et al. Ether-phosphatidylcholine characterized by consolidated plasma and liver lipidomics is a predictive biomarker for valproic acid-induced hepatic steatosis. , 2018, The Journal of toxicological sciences.
[42] Xiaowei Wang,et al. Valproic acid sensitizes breast cancer cells to hydroxyurea through inhibiting RPA2 hyperphosphorylation-mediated DNA repair pathway. , 2017, DNA repair.
[43] J. Kleinjans,et al. Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes , 2017, Chemical research in toxicology.
[44] R. Heidari,et al. Valproic Acid-Induced Hepatotoxicity and the Protective Role of Thiol Reductants , 2017 .
[45] E. Zamani,et al. Zinc Deficiency and Oxidative Stress Involved in Valproic Acid Induced Hepatotoxicity: Protection by Zinc and Selenium Supplementation , 2017, Biological Trace Element Research.
[46] Shufeng Zhou,et al. Computational Identification of the Paralogs and Orthologs of Human Cytochrome P450 Superfamily and the Implication in Drug Discovery , 2016, International journal of molecular sciences.
[47] C. Anuradha,et al. High-calorie diet inflates steatogenic effects of valproic acid in mice , 2016, Toxicology mechanisms and methods.
[48] B. Stefanovic,et al. Valproic acid suppresses collagen by selective regulation of Smads in conjunctival fibrosis , 2015, Journal of Molecular Medicine.
[49] H. Nishiura,et al. Sodium valproate, a histone deacetylase inhibitor, modulates the vascular endothelial growth inhibitor-mediated cell death in human osteosarcoma and vascular endothelial cells. , 2015, International journal of oncology.
[50] G. Jena,et al. Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat. , 2015, Experimental and molecular pathology.
[51] A. Elmarakby,et al. Valproate-Induced Liver Injury: Modulation by the Omega-3 Fatty Acid DHA Proposes a Novel Anticonvulsant Regimen , 2014, Drugs in R&D.
[52] P. Pockros,et al. Drug-induced liver injury from antiepileptic drugs. , 2013, Clinics in liver disease.
[53] M. Neuman,et al. Adverse drug reactions induced by valproic acid. , 2013, Clinical biochemistry.
[54] M. Hosseini,et al. Toxicity of valproic acid in isolated rat liver mitochondria , 2013, Toxicology mechanisms and methods.
[55] R. Altman,et al. Valproic acid pathway: pharmacokinetics and pharmacodynamics , 2013, Pharmacogenetics and genomics.
[56] M. Arafa,et al. Influence of Silymarin on Valproic Acid Induced Hepatotoxicity in Adult Male Albino Rats , 2013 .
[57] R. Yanardag,et al. Effects of vitamin U (S-methyl methionine sulphonium chloride) on valproic acid induced liver injury in rats. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[58] J. Pourahmad,et al. A new approach on valproic acid induced hepatotoxicity: involvement of lysosomal membrane leakiness and cellular proteolysis. , 2012, Toxicology in vitro : an international journal published in association with BIBRA.
[59] A. El-Mowafy,et al. Eicosapentaenoic acid ablates valproate-induced liver oxidative stress and cellular derangement without altering its clearance rate: dynamic synergy and therapeutic utility. , 2011, Biochimica et biophysica acta.
[60] Tony K. L. Kiang,et al. Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity. , 2011, Toxicology and applied pharmacology.
[61] B. Fromenty,et al. Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver. , 2011, Journal of hepatology.
[62] William M. Lee,et al. Drug‐induced acute liver failure: Results of a U.S. multicenter, prospective study , 2010, Hepatology.
[63] R. Naviaux,et al. POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders , 2010, Seizure.
[64] J. -. Park,et al. TNF-α-induced ROS production triggering apoptosis is directly linked to Romo1 and Bcl-XL , 2010, Cell Death and Differentiation.
[65] I. T. de Almeida,et al. Inhibition of hepatic carnitine palmitoyl-transferase I (CPT IA) by valproyl-CoA as a possible mechanism of valproate-induced steatosis. , 2010, Biochemical pharmacology.
[66] E. Trinka,et al. Non-alcoholic fatty liver disease (NAFLD), insulin resistance and lipid profile in antiepileptic drug treatment , 2009, Epilepsy Research.
[67] I. Harting,et al. Status epilepticus in children with Alpers’ disease caused by POLG1 mutations: EEG and MRI features , 2009, Epilepsia.
[68] K. Meador,et al. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. , 2009, The New England journal of medicine.
[69] F. Chiarelli,et al. Nonalcoholic fatty liver disease during valproate therapy , 2009, European Journal of Pediatrics.
[70] R. Remmel,et al. Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10 , 2009, Drug Metabolism and Disposition.
[71] M. Zeviani,et al. 155th ENMC workshop: Polymerase gamma and disorders of mitochondrial DNA synthesis, 21–23 September 2007, Naarden, The Netherlands , 2008, Neuromuscular Disorders.
[72] You-Sun Kim,et al. TNFα and reactive oxygen species in necrotic cell death , 2008, Cell Research.
[73] A. Bergquist,et al. Acute liver failure in Sweden: etiology and outcome , 2007, Journal of internal medicine.
[74] N. Chalasani,et al. Etiology of New-Onset Jaundice: How Often Is It Caused by Idiosyncratic Drug-Induced Liver Injury in The United States? , 2007, The American Journal of Gastroenterology.
[75] Xin Zhou,et al. Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia , 2007, Biological Trace Element Research.
[76] C. Eapen,et al. Oxidative stress in experimental liver microvesicular steatosis: Role of mitochondria and peroxisomes , 2006, Journal of gastroenterology and hepatology.
[77] David A. Brenner,et al. Mechanisms of Liver Injury. I. TNF-α-induced liver injury: role of IKK, JNK, and ROS pathways , 2006 .
[78] G. Karikas,et al. Valproic acid monotherapy induces DNA oxidative damage. , 2006, Toxicology.
[79] Thomas K. H. Chang,et al. Oxidative Stress as a Mechanism of Valproic Acid-Associated Hepatotoxicity , 2006, Drug metabolism reviews.
[80] Thomas K. H. Chang,et al. Valproic acid I: time course of lipid peroxidation biomarkers, liver toxicity, and valproic acid metabolite levels in rats. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.
[81] Thomas K. H. Chang,et al. Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.
[82] D. Wysowski,et al. Adverse drug event surveillance and drug withdrawals in the United States, 1969-2002: the importance of reporting suspected reactions. , 2005, Archives of internal medicine.
[83] Thomas K. H. Chang,et al. Valproic acid glucuronidation is associated with increases in 15-F2t-isoprostane in rats. , 2005, Free radical biology & medicine.
[84] D. Wyszynski,et al. Teratogenicity of sodium valproate , 2005, Expert opinion on drug safety.
[85] E. Trinka,et al. Valproate therapy and nonalcoholic fatty liver disease , 2004, Annals of neurology.
[86] S. Johannessen,et al. Valproate: past, present, and future. , 2006, CNS drug reviews.
[87] Thomas K. H. Chang,et al. The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats. , 2003, Free radical biology & medicine.
[88] H. Wong,et al. Disposition of valproic acid in maternal, fetal, and newborn sheep. I: placental transfer, plasma protein binding, and clearance. , 2000, Drug metabolism and disposition: the biological fate of chemicals.
[89] M. Uysal,et al. Effect of acute and chronic administration of sodium valproate on lipid peroxidation and antioxidant system in rat liver. , 1999, Pharmacology & toxicology.
[90] M. Nagao,et al. Influence of valproic acid on the expression of various acyl‐CoA dehydrogenases in rats , 1999, Pediatrics international : official journal of the Japan Pediatric Society.
[91] H. Nau,et al. Valproate (VPA) Metabolites in Various Clinical Conditions of Probable VPA‐Associated Hepatotoxicity , 1993, Epilepsia.
[92] S. Evans,et al. Early changes in hepatic redox homeostasis following treatment with a single dose of valproic acid. , 1990, Biochemical pharmacology.
[93] P. Friel. Valproyl CoA: an active metabolite of valproate? , 1990, Medical hypotheses.
[94] G. Zaccara,et al. Clinical Pharmacokinetics of Valproic Acid — 1988 , 1988, Clinical pharmacokinetics.
[95] W. Maenhaut,et al. Selenium, zinc, and copper changes with valproic acid , 1984, Neurology.
[96] G. Carraz,et al. [Pharmacodynamic properties of N-dipropylacetic acid]. , 1963, Therapie.