Non-stationary convolution subtraction scatter correction with a dual-exponential scatter kernel for the Hamamatsu SHR-7700 animal PET scanner.

A spatially variant convolution subtraction scatter correction was developed for a Hamamatsu SHR-7700 animal PET scanner. This scanner, with retractable septa and a gantry that can be tilted 90 degrees, was designed for studies of conscious monkeys. The implemented dual-exponential scatter kernel takes into account both radiation scattered inside the object and radiation scattered in gantry and detectors. This is necessary because of the relatively large contribution of gantry and detector scatter in this scanner. The correction is used for scatter correction of emission as well as transmission data. Transmission scatter correction using the dual-exponential kernel leads to a measured attenuation coefficient of 0.096 cm(-1) in water, compared to 0.089 cm(-1) without scatter correction. Scatter correction on both emission and transmission data resulted in a residual correction error of 2.1% in water, as well as improved image contrast and hot spot quantification.

[1]  G Brix,et al.  Performance evaluation of a whole-body PET scanner using the NEMA protocol. National Electrical Manufacturers Association. , 1997, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[2]  M. Lubberink,et al.  Quantitative imaging and correction for cascade gamma radiation of 76Br with 2D and 3D PET. , 2002, Physics in medicine and biology.

[3]  D. Newport,et al.  Evaluation of simulation-based scatter correction for 3-D PET cardiac imaging , 1995 .

[4]  M E Bellemann,et al.  Monte Carlo-based analysis of PET scatter components. , 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[5]  Jean Logan,et al.  Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[6]  T. Kosugi,et al.  A new high resolution PET scanner dedicated to brain research , 2001 .

[7]  C. Bohm,et al.  Correction for Scattered Radiation in a Ring Detector Positron Camera by Integral Transformation of the Projections , 1983, Journal of computer assisted tomography.

[8]  R Lecomte,et al.  Assessment of scatter components in high-resolution PET: correction by nonstationary convolution subtraction. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  Arion F. Chatziioannou,et al.  Molecular imaging of small animals with dedicated PET tomographs , 2001, European Journal of Nuclear Medicine and Molecular Imaging.

[10]  Hiroyuki Okada,et al.  A high resolution animal PET scanner using compact PS-PMT detectors , 1996 .

[11]  E. Hoffman,et al.  Performance standards in positron emission tomography. , 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.