CpG oligodeoxinucleotides functions as an effective adjuvant in aged BALB/c mice.

[1]  J. Blackwell,et al.  IL-10 from Regulatory T Cells Determines Vaccine Efficacy in Murine Leishmania major Infection1 , 2005, The Journal of Immunology.

[2]  Miriam V. Liscovsky,et al.  Orally administered OVA/CpG‐ODN induces specific mucosal and systemic immune response in young and aged mice , 2005, Journal of leukocyte biology.

[3]  B. Trapnell,et al.  Disruption of granulocyte macrophage‐colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection , 2005, Journal of leukocyte biology.

[4]  R. Chelvarajan,et al.  The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function , 2005, Journal of leukocyte biology.

[5]  S. Swain,et al.  Inflammatory Cytokines Overcome Age-Related Defects in CD4 T Cell Responses In Vivo1 , 2004, The Journal of Immunology.

[6]  D. Klinman Immunotherapeutic uses of CpG oligodeoxynucleotides , 2004, Nature Reviews Immunology.

[7]  M. Zöller,et al.  Donor T cell and host NK depletion improve the therapeutic efficacy of allogeneic bone marrow cell reconstitution in the nonmyeloablatively conditioned tumor‐bearing host , 2002, Journal of leukocyte biology.

[8]  A. Rópolo,et al.  CpG‐DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice , 2002, Journal of leukocyte biology.

[9]  M. Calcagno,et al.  Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen. , 2002, Microbes and infection.

[10]  R. Daynes,et al.  CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice , 2001, Experimental Gerontology.

[11]  J. Giorgi,et al.  Preparation of Cells and Reagents for Flow Cytometry , 2001, Current protocols in immunology.

[12]  E. Brummer,et al.  Effects of granulocyte‐macrophage colony stimulating factor (GM‐CSF) in vivo on cytokine production and proliferation by spleen cells , 2001, Clinical and experimental immunology.

[13]  S. Akira,et al.  A Toll-like receptor recognizes bacterial DNA , 2000, Nature.

[14]  V E Schijns,et al.  Immunological concepts of vaccine adjuvant activity. , 2000, Current opinion in immunology.

[15]  A. O’Garra,et al.  Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells , 2000, The Journal of experimental medicine.

[16]  C. de Wolf‐Peeters,et al.  Enhanced autoimmune arthritis in IFN-gamma receptor-deficient mice is conditioned by mycobacteria in Freund's adjuvant and by increased expansion of Mac-1+ myeloid cells. , 1999, Journal of immunology.

[17]  L. Liotta,et al.  A model for CD8+ CTL tumor immunosurveillance and regulation of tumor escape by CD4 T cells through an effect on quality of CTL. , 1999, Journal of immunology.

[18]  P. Lehmann,et al.  Adjuvant-guided type-1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response. , 1999, Journal of immunology.

[19]  L. Hültner,et al.  Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis. , 1999, Journal of immunology.

[20]  W. Ouyang,et al.  Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. , 1998, Immunity.

[21]  K. Rock,et al.  Fully mobilizing host defense: Building better vaccines , 1998, Nature Biotechnology.

[22]  C. Harding,et al.  CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity , 1997, The Journal of experimental medicine.

[23]  Richard A Flavell,et al.  The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells , 1997, Cell.

[24]  G. Shearer,et al.  Th1/Th2 changes in aging. , 1997, Mechanisms of ageing and development.

[25]  J. Cox,et al.  Adjuvants--a classification and review of their modes of action. , 1997, Vaccine.

[26]  S. Beaucage,et al.  CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[27]  A. Krieg,et al.  IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. , 1996, Journal of immunology.

[28]  G. Bishop,et al.  CpG motifs in bacterial DNA trigger direct B-cell activation , 1995, Nature.

[29]  M. C. Pistoresi-Palencia,et al.  Aging: the cellular immune response against autologous and foreign antigens is affected before the humoral response. , 1994, Immunology letters.

[30]  D. Metcalf,et al.  Cellular and molecular basis of the increased splenic hemopoiesis in mice treated with bacterial cell wall components. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[31]  C. Galanos,et al.  Lipid A, the active part of bacterial endotoxins in inducing serum colony stimulating activity and proliferation of splenic granulocyte/macrophage progenitor cells , 1976, Journal of cellular physiology.

[32]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[33]  E. Gardner,et al.  Age-related changes in Type 1 and Type 2 cytokine production in humans , 2004, Biogerontology.

[34]  B. Boehm,et al.  Immunological adjuvants efficiently induce antigen-specific T cell responses in old mice: implications for vaccine adjuvant development in aged individuals. , 2002, Cellular immunology.

[35]  B. Grubeck‐Loebenstein,et al.  The aging of the immune system. , 2002, Advances in immunology.

[36]  Roland M. Martin,et al.  Is IgG2a a good Thl marker in mice , 1998 .

[37]  R. Gupta,et al.  The role of adjuvants and delivery systems in modulation of immune response to vaccines. , 1996, Advances in experimental medicine and biology.

[38]  E. Coligan Current protocols in immunology , 1991 .

[39]  Andreas Radbruch,et al.  Immunoglobulin class switching: molecular and cellular analysis. , 1990, Annual review of immunology.