Vascularization Methods for Tissue Engineers

Tissue engineering is limited by our inability to adequately vascularize tissues post implantation because all tissue-engineered substitutes (with the exception of cornea and cartilage) require a vascular network to provide the nutrient and oxygen supply needed for their survival. This review gives a brief overview of the processes and factors involved in the vascularization and angiogenesis and summarizes the different strategies to overcome the issue of slow vascularization and angiogenesis in a range of tissue-engineered substitutes. Moreover, we will announce some potential future plans. (Korean J Urol Oncol 2017;15:51-58) 󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏󰠏

[1]  L. Griffith,et al.  A microfabricated array bioreactor for perfused 3D liver culture. , 2002, Biotechnology and bioengineering.

[2]  H. Guadalajara,et al.  Autologous Expanded Adipose-Derived Stem Cells for the Treatment of Complex Cryptoglandular Perianal Fistulas: A Phase III Randomized Clinical Trial (FATT 1 Fistula Advanced Therapy Trial 1) and Long-term Evaluation , 2012, Diseases of the colon and rectum.

[3]  A. Ahluwalia,et al.  Critical role of hypoxia sensor--HIF-1α in VEGF gene activation. Implications for angiogenesis and tissue injury healing. , 2012, Current medicinal chemistry.

[4]  A. Mathur,et al.  IFATS Collection: Human Adipose‐Derived Stem Cells Seeded on a Silk Fibroin‐Chitosan Scaffold Enhance Wound Repair in a Murine Soft Tissue Injury Model , 2009, Stem cells.

[5]  Masayuki Yamato,et al.  Engineering functional two- and three-dimensional liver systems in vivo using hepatic tissue sheets , 2007, Nature Medicine.

[6]  G. Vunjak‐Novakovic,et al.  The effect of controlled expression of VEGF by transduced myoblasts in a cardiac patch on vascularization in a mouse model of myocardial infarction. , 2013, Biomaterials.

[7]  N. Fusenig,et al.  Tumour angiogenesis : basic mechanisms and cancer therapy , 2008 .

[8]  Helen Song,et al.  Interaction of angiogenic microvessels with the extracellular matrix. , 2007, American journal of physiology. Heart and circulatory physiology.

[9]  N. Ferrara,et al.  The Role of Vascular Endothelial Growth Factor in Angiogenesis , 2002, Acta Haematologica.

[10]  Masayuki Yamato,et al.  Bioengineered cardiac cell sheet grafts have intrinsic angiogenic potential. , 2006, Biochemical and biophysical research communications.

[11]  M Przybylski,et al.  A review of the current research on the role of bFGF and VEGF in angiogenesis. , 2009, Journal of wound care.

[12]  Valerie M. Weaver,et al.  The extracellular matrix at a glance , 2010, Journal of Cell Science.

[13]  James J. Yoo,et al.  Tissue-engineered autologous bladders for patients needing cystoplasty , 2006, The Lancet.

[14]  Noo Li Jeon,et al.  Diffusion limits of an in vitro thick prevascularized tissue. , 2005, Tissue engineering.

[15]  Peter Carmeliet,et al.  Manipulating angiogenesis in medicine , 2004, Journal of internal medicine.

[16]  Mitsuo Umezu,et al.  In vitro fabrication of functional three-dimensional tissues with perfusable blood vessels , 2013, Nature Communications.

[17]  C. Heldin,et al.  PDGF and vessel maturation. , 2010, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[18]  Yuanyuan Zhang,et al.  Coadministration of platelet-derived growth factor-BB and vascular endothelial growth factor with bladder acellular matrix enhances smooth muscle regeneration and vascularization for bladder augmentation in a rabbit model. , 2013, Tissue engineering. Part A.

[19]  P. Carmeliet.  Angiogenesis in health and disease , 2003, Nature Medicine.

[20]  Sybill Patan,et al.  Vasculogenesis and Angiogenesis as Mechanisms of Vascular Network Formation, Growth and Remodeling , 2000, Journal of Neuro-Oncology.

[21]  Benoit Hendrickx,et al.  Integration of Blood Outgrowth Endothelial Cells in Dermal Fibroblast Sheets Promotes Full Thickness Wound Healing , 2010, Stem cells.

[22]  D. Supp,et al.  Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor. , 2000, The Journal of investigative dermatology.

[23]  J. Harmey,et al.  Angiogenic and cell survival functions of Vascular Endothelial Growth Factor (VEGF) , 2005, Journal of cellular and molecular medicine.

[24]  B. Krock,et al.  Hypoxia-induced angiogenesis: good and evil. , 2011, Genes & cancer.

[25]  Ruslan Hlushchuk,et al.  Intussusceptive angiogenesis: Its emergence, its characteristics, and its significance , 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

[26]  Wei Chen,et al.  Bladder regeneration by collagen scaffolds with collagen binding human basic fibroblast growth factor. , 2010, The Journal of urology.

[27]  J. Santibañez,et al.  TGF-β/TGF-β receptor system and its role in physiological and pathological conditions. , 2011, Clinical science.

[28]  Takanori Takebe,et al.  Vascularized and functional human liver from an iPSC-derived organ bud transplant , 2013, Nature.

[29]  Korkut Uygun,et al.  Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. , 2011, Annual review of biomedical engineering.

[30]  H. Cheng,et al.  Quantifying angiogenesis in VEGF‐enhanced tissue‐engineered bladder constructs by dynamic contrast‐enhanced MRI using contrast agents of different molecular weights , 2007, Journal of magnetic resonance imaging : JMRI.

[31]  B. Garmy-Susini,et al.  Integrins in angiogenesis and lymphangiogenesis , 2008, Nature Reviews Cancer.

[32]  Hiroshi Yagi,et al.  Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix , 2010, Nature Medicine.

[33]  M. Przybylski.  A review of the current research on the role of bFGF and VEGF in , 2009 .

[34]  Pedro M. Baptista,et al.  The use of whole organ decellularization for the generation of a vascularized liver organoid , 2011, Hepatology.

[35]  Christopher C W Hughes,et al.  Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. , 2008, Circulation research.

[36]  W. Morrison,et al.  Generation of an autologous tissue (matrix) flap by combining an arteriovenous shunt loop with artificial skin in rats: preliminary report. , 2000, British journal of plastic surgery.

[37]  Igor Tudorache,et al.  Biological vascularized matrix for bladder tissue engineering: matrix preparation, reseeding technique and short-term implantation in a porcine model. , 2005, The Journal of urology.

[38]  M. Goumans,et al.  Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways. , 2011, Histology and histopathology.

[39]  Jennifer R. Hurley,et al.  Complex temporal regulation of capillary morphogenesis by fibroblasts. , 2010, American journal of physiology. Cell physiology.

[40]  J. Vacanti,et al.  Tissue Engineering and Organ Structure: A Vascularized Approach to Liver and Lung , 2008, Pediatric Research.

[41]  A. Ramamurthi,et al.  Role of hyaluronan in angiogenesis and its utility to angiogenic tissue engineering , 2008, Organogenesis.

[42]  Gordana Vunjak-Novakovic,et al.  Bioengineering heart muscle: a paradigm for regenerative medicine. , 2011, Annual review of biomedical engineering.

[43]  Richard O. Hynes,et al.  The Extracellular Matrix: Not Just Pretty Fibrils , 2009, Science.

[44]  Shulamit Levenberg,et al.  Transplantation of a tissue-engineered human vascularized cardiac muscle. , 2010, Tissue engineering. Part A.

[45]  J. Southgate,et al.  Regenerative medicine in urology , 2011, BJU international.

[46]  Benoit Hendrickx,et al.  Cell-based vascularization strategies for skin tissue engineering. , 2011, Tissue engineering. Part B, Reviews.

[47]  A. Bura,et al.  Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. , 2014, Cytotherapy.

[48]  Y. Tabata,et al.  Enhanced angiogenesis by gelatin hydrogels incorporating basic fibroblast growth factor in rabbit model of hind limb ischemia , 2007, Heart and Vessels.

[49]  Teruo Fujii,et al.  Microfluidic PDMS (Polydimethylsiloxane) Bioreactor for Large‐Scale Culture of Hepatocytes , 2004, Biotechnology progress.

[50]  K. Bendixen,et al.  Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue , 2009, Proceedings of the National Academy of Sciences.

[51]  D. Mooney,et al.  Polymeric system for dual growth factor delivery , 2001, Nature Biotechnology.

[52]  David J Mooney,et al.  Delivery of hepatotrophic factors fails to enhance longer-term survival of subcutaneously transplanted hepatocytes. , 2006, Tissue engineering.

[53]  N. Pallua,et al.  Human Bone Marrow Mesenchymal Stem Cells Seeded on Modified Collagen Improved Dermal Regeneration In Vivo , 2006, Cell transplantation.

[54]  Tal Dvir,et al.  Prevascularization of cardiac patch on the omentum improves its therapeutic outcome , 2009, Proceedings of the National Academy of Sciences.

[55]  J. Schechner,et al.  In Vivo Perfusion of Human Skin Substitutes With Microvessels Formed by Adult Circulating Endothelial Progenitor Cells , 2008, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[56]  Hong Bu,et al.  Construction of a Portal Implantable Functional Tissue-Engineered Liver Using Perfusion-Decellularized Matrix and Hepatocytes in Rats , 2011, Cell transplantation.

[57]  Subbu S Venkatraman,et al.  Thick acellular heart extracellular matrix with inherent vasculature: a potential platform for myocardial tissue regeneration. , 2012, Tissue engineering. Part A.

[58]  P. Carmeliet.  Mechanisms of angiogenesis and arteriogenesis , 2000, Nature Medicine.

[59]  E. Brey.  Vascularization: Regenerative Medicine and Tissue Engineering , 2014 .

[60]  C James Kirkpatrick,et al.  The rapid anastomosis between prevascularized networks on silk fibroin scaffolds generated in vitro with cocultures of human microvascular endothelial and osteoblast cells and the host vasculature. , 2010, Biomaterials.