Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions

In spite of the experience gained in human space flight since Yuri Gagarin’s historical flight in 1961, there has yet to be identified a completely effective countermeasure for mitigating the effects of weightlessness on humans. Were astronauts to embark upon a journey to Mars today, the 6-month exposure to weightlessness en route would leave them considerably debilitated, even with the implementation of the suite of piece-meal countermeasures currently employed. Continuous or intermittent exposure to simulated gravitational states on board the spacecraft while traveling to and from Mars, also known as artificial gravity, has the potential for enhancing adaptation to Mars gravity and re-adaptation to Earth gravity. Many physiological functions are adversely affected by the weightless environment of spaceflight because they are calibrated for normal, Earth’s gravity. Hence, the concept of artificial gravity is to provide a broad-spectrum replacement for the gravitational forces that naturally occur on the Earth’s surface, thereby avoiding the physiological deconditioning that takes place in weightlessness. Because researchers have long been concerned by the adverse sensorimotor effects that occur in weightlessness as well as in rotating environments, additional study of the complex interactions among sensorimotor and other physiological systems in rotating environments must be undertaken both on Earth and in space before artificial gravity can be implemented.

[1]  Stuart M. C. Lee,et al.  Upright exercise or supine lower body negative pressure exercise maintains exercise responses after bed rest. , 1997, Medicine and science in sports and exercise.

[2]  J. Greenleaf,et al.  Cycle-powered short radius (1.9M) centrifuge: exercise vs. passive acceleration. , 1996, Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology.

[3]  F E Guedry,et al.  Microgravity vestibular investigations: perception of self-orientation and self-motion. , 1997, Journal of vestibular research : equilibrium & orientation.

[4]  M. Reschke,et al.  Neuroscience in space , 2008 .

[5]  A. Hargens,et al.  LBNP treadmill exercise maintains spine function and muscle strength in identical twins during 28-day simulated microgravity. , 2007, Journal of applied physiology.

[6]  R. W. Stone,et al.  Some observations on the stimulation of the vestibular system of man in a rotating environment , 1965 .

[7]  H Sandler,et al.  Artificial gravity. , 2018, Acta astronautica.

[8]  Satoshi Iwase,et al.  Effectiveness of centrifuge-induced artificial gravity with ergometric exercise as a countermeasure during simulated microgravity exposure in humans. , 2003, Acta astronautica.

[9]  G. Clément,et al.  Centrifugation as a countermeasure during actual and simulated microgravity: a review , 2004, European Journal of Applied Physiology.

[10]  Donald E. Watenpaugh,et al.  WISE-2005: effect of aerobic and resistive exercises on orthostatic tolerance during 60 days bed rest in women , 2009, European Journal of Applied Physiology.

[11]  William H Paloski,et al.  Postural reflexes, balance control, and functional mobility with long-duration head-down bed rest. , 2009, Aviation, space, and environmental medicine.

[12]  A GRAYBIEL,et al.  HUMAN PERFORMANCE DURING TWO WEEKS IN A ROOM ROTATING AT THREE RPM. , 1964, Aerospace medicine.

[13]  Peter R Cavanagh,et al.  A novel lunar bed rest analogue. , 2013, Aviation, space, and environmental medicine.

[14]  Daniel L. Feeback,et al.  Resistance exercise as a countermeasure to disuse-induced bone loss. , 2004, Journal of applied physiology.

[15]  Larry A Kramer,et al.  Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. , 2011, Ophthalmology.

[16]  A Graybiel,et al.  Prevention of overt motion sickness by incremental exposure to otherwise highly stressful coriolis accelerations. , 1968, Aerospace medicine.

[17]  B. Cohen,et al.  Perception of tilt (somatogravic illusion) in response to sustained linear acceleration during space flight , 2001, Experimental Brain Research.

[18]  J. Lackner,et al.  Human orientation and movement control in weightless and artificial gravity environments , 2000, Experimental Brain Research.

[19]  Scott M Smith,et al.  Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins. , 2007, Bone.

[20]  Kimberly A Seaton,et al.  Cognitive functioning in long-duration head-down bed rest. , 2009, Aviation, space, and environmental medicine.

[21]  P. E. D. Prampero,et al.  Cycling on Earth, in space, on the Moon , 2000, European Journal of Applied Physiology.

[22]  B. Levine,et al.  Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest. , 2010, Journal of applied physiology.

[23]  J. D. Hunley,et al.  The problem of space travel: The rocket motor , 1995 .

[24]  D Linnarsson,et al.  Elevated serum soluble CD200 and CD200R as surrogate markers of bone loss under bed rest conditions. , 2014, Bone.

[25]  Matthias Abend,et al.  Fundamentals Of Space Medicine , 2016 .

[26]  A. Graybiel,et al.  Experiment M131. Human vestibular function , 1973 .

[27]  F O Black,et al.  Medical investigations and resulting countermeasures in support of 16-day Space Shuttle missions. , 1998, Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology.

[28]  L R Young,et al.  Artificial gravity: head movements during short-radius centrifugation. , 2001, Acta astronautica.

[29]  L. Young,et al.  Neurovestibular effects of bed rest and centrifugation. , 2010, Journal of vestibular research : equilibrium & orientation.

[30]  S. Moore,et al.  Effects of head-down bed rest and artificial gravity on spatial orientation , 2010, Experimental Brain Research.

[31]  A. A. Spady,et al.  Walking in Simulated Lunar Gravity , 1970 .

[32]  A Guell,et al.  Cardiovascular and hormonal changes induced by a simulation of a lunar mission. , 1997, Aviation, space, and environmental medicine.

[33]  Rex Hay Wu,et al.  Human readaptation to normal gravity following short-term simulated Martian gravity exposure and the effectiveness of countermeasures , 1999 .

[34]  Arthur Kreitenberg,et al.  Hemodynamic and metabolic responses to hypergravity on a human-powered centrifuge. , 2004, Aviation, space, and environmental medicine.

[35]  Stuart M. C. Lee,et al.  Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance. , 2007, Journal of applied physiology.

[36]  Hiroki Takada,et al.  Acceleration with exercise during head-down bed rest preserves upright exercise responses. , 2004, Aviation, space, and environmental medicine.

[37]  Theodore Raphan,et al.  Artificial gravity: a possible countermeasure for post-flight orthostatic intolerance. , 2005, Acta astronautica.

[38]  L R Young,et al.  Perception of linear acceleration in weightlessness. , 1990, Aviation, space, and environmental medicine.

[39]  R. Kennedy,et al.  EFFECTS OF EXPOSURE TO A ROTATING ENVIRONMENT (10 RPM) ON FOUR AVIATORS FOR A PERIOD OF TWELVE DAYS. , 1965, Aerospace medicine.

[40]  M. Heer,et al.  Effects of artificial gravity during bed rest on bone metabolism in humans. , 2009, Journal of applied physiology.

[41]  Ray Bert.  \IOut of This World: The New Field of Space Architecture\N, edited by A. Scott Howe and Brent Sherwood. Reston, VA: American Institute of Aeronautics and Astronautics, Inc., 2009. , 2010 .

[42]  Eric L. Groen,et al.  The perception of verticality in lunar and Martian gravity conditions , 2012, Neuroscience Letters.

[43]  T Kinoue,et al.  Effects of repeated long duration +2Gz load on man's cardiovascular function. , 1998, Acta astronautica.

[44]  Tadaaki Mano,et al.  Hypergravity exercise against bed rest induced changes in cardiac autonomic control , 2005, European Journal of Applied Physiology.

[45]  G Antonutto,et al.  On-Earth evaluation of neurovestibular tolerance to centrifuge simulated artificial gravity in humans. , 1993, The Physiologist.

[46]  Gilles Clément,et al.  Effects of an artificial gravity countermeasure on orthostatic tolerance, blood volumes and aerobic power after short-term bed rest (BR-AG1). , 2015, Journal of applied physiology.

[47]  A GRAYBIEL,et al.  Observations on human subjects living in a "slow rotation room" for periods of two days. , 1960, Archives of neurology.

[48]  Laurence R. Harris,et al.  How Much Gravity Is Needed to Establish the Perceptual Upright? , 2014, PloS one.

[49]  A GRAYBIEL,et al.  Symptomatology during prolonged exposure in a constantly rotating environment at a velocity of one revolution per minute. , 1961, Aerospace medicine.

[50]  F. Wuyts,et al.  Effects of five days of bed rest with and without exercise countermeasure on postural stability and gait. , 2014, Journal of musculoskeletal & neuronal interactions.

[51]  R. W. Stone.  An overview of artificial gravity , 2006 .

[52]  F. Guedry,et al.  Coriolis cross-coupling effects: disorienting and nauseogenic or not? , 1978, Aviation, space, and environmental medicine.

[53]  Jason D Peeler,et al.  Lower body positive pressure: an emerging technology in the battle against knee osteoarthritis? , 2013, Clinical interventions in aging.

[54]  K Hirayanagi,et al.  Usefulness of daily +2Gz load as a countermeasure against physiological problems during weightlessness. , 2001, Acta astronautica.

[55]  A. J. Benson,et al.  European vestibular experiments on the Spacelab-1 mission: 4. Thresholds of perception of whole-body linear oscillation , 2004, Experimental Brain Research.