Adriamycin and enhanced radiation reaction in normal esophagus and skin.

Clinical evaluation of 10 patients with small cell carcinoma of the lung treated with radiotherapy and periodic cycles of combination chemotherapy with cyclophosphamide, vincristine, and adriamycin showed frequent and occasionally severe esophageal and skin reactions. Eight of the 10 patients had esophagitis, four required supportive intravenous fluids, and two subsequently developed esophageal narrowing and stricture formation. Recurrent esophagitis with augmentation of injury in the recently irradiated esophagus was observed 11 times in eight of the 10 patients after cycles of chemotherapy, and contributed to the sustained toxicity seen in two patients. Dermatitis in the form of moist desquamation was observed in five of the patients at very low doses of supervoltage radiation therapy. Acute pulmonary reactions was notably absent. This combination of chemotherapy, particularly adriamycin, potentiates the effect of radiotherapy on the normal esophagus and skin, and further implicates the radiosensitizing property of adriamycin.

[1]  J. Cassady,et al.  Radiation‐adriamycin interactions: Preliminary clinical observations , 1975, Cancer.

[2]  S. Hellman,et al.  Normal tissue responses to radiation therapy. , 1975, The New England journal of medicine.

[3]  G. Ramírez,et al.  Clinical and theoretical aspects of the treatment of surgically unresectable retroperitoneal malignancy with combined intra‐arterial actinomycin‐d and radiotherapy , 1975, Cancer.

[4]  T. Phillips,et al.  Modification of radiation injury to normal tissues by chemotherapeutic agents , 1975, Cancer.

[5]  L. Lagasse,et al.  Combination Adriamycin and radiation therapy in gynecologic cancers. , 1974, Gynecologic oncology.

[6]  S. Donaldson,et al.  Adriamycin Activating a Recall Phenomenon After Radiation Therapy , 1974 .

[7]  R. J. Forcier,et al.  Small cell carcinoma of the lung: Staging, paraneoplastic syndromes, treatment, and survival , 1974 .

[8]  D. White,et al.  Lung cancer: Clinical trial of radiotherapy alone vs. Radiotherapy plus cyclophosphamide , 1972, Cancer.

[9]  H. Hansen,et al.  Intensive combined chemotherapy and radiotherapy in patients with nonresectable bronchogenic carcinoma , 1972, Cancer.

[10]  D. Carr,et al.  Radiotherapy plus 5‐Fu compared to radiotherapy alone for inoperable and unresectable bronchogenic carcinoma , 1972, Cancer.

[11]  E. Kano,et al.  Actinomycin D and radiation fractionation studies in asynchronous and synchronized Chinese hamster cells. , 1970, Radiation research.

[12]  M. Friedman,et al.  Treatment of squamous cell carcinoma of the head and neck with combined methotrexate and irradiation , 1970, Cancer.

[13]  G. D'angio,et al.  Potentiation of x-ray effects by actinomycin D. , 1959, Radiology.

[14]  L. Ackerman,et al.  The effect of radiation on the esophagus; a clinical and histologic study of the effects produced by the betatron. , 1957, Radiology.

[15]  S. Teichman,et al.  Nephrotic proteinuria in obesity. , 1975, Annals of internal medicine.

[16]  H. Brereton,et al.  Adriamycin and radiation: synegistic cardiotoxicity. , 1975, Annals of internal medicine.

[17]  L. Lajtha,et al.  Radiation damage and repair phenomena. , 1973, British medical bulletin.

[18]  J. Holland,et al.  Therapeutic effect and toxicity of adriamycin in patients with neoplastic disease , 1971, Cancer.

[19]  F. Ansfield,et al.  Clinical Studies of 5-Fluorouracil as Adjuvant to Radiotherapy1 , 1969 .