Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer

[1]  A. Erdei,et al.  Effects of adult growth hormone deficiency and replacement therapy on the cardiometabolic risk profile , 2022, Pituitary.

[2]  S. Melmed,et al.  Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage , 2021, Cell reports.

[3]  S. Melmed,et al.  GH and Senescence: A New Understanding of Adult GH Action , 2021, Journal of the Endocrine Society.

[4]  S. Yakar,et al.  Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan , 2021, Aging cell.

[5]  G. Johannsson,et al.  Growth hormone deficiency in adults with hypopituitarism—What are the risks and can they be eliminated by therapy? , 2021, Journal of internal medicine.

[6]  Elizabeth A. Jensen,et al.  Growth hormone alters gross anatomy and morphology of the small and large intestines in age- and sex-dependent manners , 2021, Pituitary.

[7]  Q. Luo,et al.  Regulation of the IGF1 signaling pathway is involved in idiopathic pulmonary fibrosis induced by alveolar epithelial cell senescence and core fucosylation , 2021, Aging.

[8]  S. Bansal,et al.  Immune cell Dilemma in Ischemic Cardiomyopathy: To Heal or Not to Heal. , 2021, Current opinion in physiology.

[9]  Hongzhu Yan,et al.  GHR is involved in gastric cell growth and apoptosis via PI3K/AKT signalling , 2021, Journal of cellular and molecular medicine.

[10]  D. Lantvit,et al.  Mammary Tumors Growing in the Absence of Growth Hormone are More Sensitive to Doxorubicin than Wild-type Tumors. , 2021, Endocrinology.

[11]  J. Kopchick,et al.  A novel peptide antagonist of the human growth hormone receptor , 2021, The Journal of biological chemistry.

[12]  E. Davis,et al.  Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo , 2020, Cancers.

[13]  V. Brunton,et al.  The fibrotic and immune microenvironments as targetable drivers of metastasis , 2020, British journal of cancer.

[14]  T. Wynn,et al.  Fibrosis: from mechanisms to medicines , 2020, Nature.

[15]  R. Salvatori,et al.  Disruption of the GHRH receptor and its impact on children and adults: The Itabaianinha syndrome , 2020, Reviews in Endocrine and Metabolic Disorders.

[16]  K. Kuboki,et al.  Role of growth hormone signaling pathways in the development of atherosclerosis. , 2020, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[17]  A. Mamelak,et al.  DNA damage and growth hormone hypersecretion in pituitary somatotroph adenomas. , 2020, The Journal of clinical investigation.

[18]  H. Hua,et al.  Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy , 2020, Journal of Hematology & Oncology.

[19]  C. Boguszewski,et al.  Metabolic syndrome and its components in adult hypopituitary patients , 2020, Pituitary.

[20]  Amanda R. Kulick,et al.  Senolytic CAR T cells reverse senescence-associated pathologies , 2020, Nature.

[21]  Raymond B. Runyan,et al.  Guidelines and definitions for research on epithelial–mesenchymal transition , 2020, Nature Reviews Molecular Cell Biology.

[22]  V. Weaver,et al.  Fibrosis and cancer: A strained relationship , 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.

[23]  C. Mantzoros,et al.  Targeted analysis of three hormonal systems identifies molecules associated with the presence and severity of NAFLD. , 2020, The Journal of clinical endocrinology and metabolism.

[24]  Gang Liu,et al.  Cell senescence and fibrotic lung diseases , 2020, Experimental Gerontology.

[25]  S. Melmed,et al.  Growth hormone in the tumor microenvironment , 2019, Archives of endocrinology and metabolism.

[26]  J. Kopchick,et al.  The effects of growth hormone on adipose tissue: old observations, new mechanisms , 2019, Nature Reviews Endocrinology.

[27]  S. Radovick,et al.  AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF GROWTH HORMONE DEFICIENCY IN ADULTS AND PATIENTS TRANSITIONING FROM PEDIATRIC TO ADULT CARE. , 2019, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[28]  J. Kopchick,et al.  The effects of growth hormone on therapy resistance in cancer , 2019, Cancer drug resistance.

[29]  E. Davis,et al.  Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma , 2019, Cancers.

[30]  C. Stokes,et al.  Hepatic steatosis in patients with acromegaly , 2019, Endocrinology, diabetes & metabolism.

[31]  A. Biankin,et al.  Prolactin promotes fibrosis and pancreatic cancer progression. , 2019, Cancer research.

[32]  R. Vettor,et al.  The Endothelium in Acromegaly , 2019, Front. Endocrinol..

[33]  R. Buckanovich,et al.  The double edge sword of fibrosis in cancer. , 2019, Translational research : the journal of laboratory and clinical medicine.

[34]  Elizabeth A. Jensen,et al.  GH "knockout" mice have increased subcutaneous adipose tissue with decreased fibrosis and enhanced insulin sensitivity. , 2019, Endocrinology.

[35]  A. Colao,et al.  Acromegaly and Heart Failure. , 2019, Heart failure clinics.

[36]  R. Holt,et al.  The Use and Abuse of Growth Hormone in Sports. , 2019, Endocrine reviews.

[37]  S. Melmed,et al.  Growth Hormone Induces Colon DNA Damage Independent of IGF-1. , 2019, Endocrinology.

[38]  Zhen Li,et al.  Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53–progerin interaction , 2019, Cell Death & Disease.

[39]  A. Bartke,et al.  Growth Hormone Deficiency: Health and Longevity. , 2018, Endocrine reviews.

[40]  J. Flanagan,et al.  Targeting growth hormone function: strategies and therapeutic applications , 2019, Signal Transduction and Targeted Therapy.

[41]  S. Melmed,et al.  Excess growth hormone suppresses DNA damage repair in epithelial cells. , 2019, JCI insight.

[42]  A. Dwivedi,et al.  Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 , 2019, Experimental & Molecular Medicine.

[43]  C. Boguszewski,et al.  Growth Hormone's Links to Cancer. , 2018, Endocrine reviews.

[44]  Elizabeth A. Jensen,et al.  Adipocyte-Specific GH Receptor-Null (AdGHRKO) Mice Have Enhanced Insulin Sensitivity With Reduced Liver Triglycerides. , 2018, Endocrinology.

[45]  M. Fleseriu,et al.  Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update. , 2018, Endocrine reviews.

[46]  M. Hudson.  Human , 2018, Critical Theory and the Classical World.

[47]  C. Boguszewski,et al.  Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis. , 2018, European journal of endocrinology.

[48]  Wei Sha,et al.  Inhibition of experimental small‐cell and non‐small‐cell lung cancers by novel antagonists of growth hormone‐releasing hormone , 2018, International journal of cancer.

[49]  K. Borbely,et al.  Resident murine macrophage migration and phagocytosis are modulated by growth hormone , 2018, Cell biology international.

[50]  J. Wit,et al.  Growth hormone — past, present and future , 2018, Nature Reviews Endocrinology.

[51]  J. Kopchick,et al.  MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects? , 2018, European journal of endocrinology.

[52]  M. Aiona,et al.  A degradation fragment of type X collagen is a real-time marker for bone growth velocity , 2017, Science Translational Medicine.

[53]  J. Kopchick,et al.  Increased fibrosis: A novel means by which GH influences white adipose tissue function. , 2017, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[54]  M. Falasca,et al.  ABC Transporters in Cancer Stem Cells: Beyond Chemoresistance , 2017, International journal of molecular sciences.

[55]  R. Horch,et al.  Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis , 2017, Nature Communications.

[56]  T. Zhu,et al.  Autocrine hGH stimulates oncogenicity, epithelial-mesenchymal transition and cancer stem cell-like behavior in human colorectal carcinoma , 2017, Oncotarget.

[57]  J. Kopchick,et al.  Growth Hormone and the Epithelial-to-Mesenchymal Transition , 2017, The Journal of clinical endocrinology and metabolism.

[58]  T. Skoglund,et al.  Higher glucocorticoid replacement doses are associated with increased mortality in patients with pituitary adenoma. , 2017, European journal of endocrinology.

[59]  L. Chung,et al.  Androgen Receptor Regulation of Local Growth Hormone in Prostate Cancer Cells , 2017, Endocrinology.

[60]  N. Oyesiku,et al.  Calcium and Bone Turnover Markers in Acromegaly: A Prospective, Controlled Study , 2017, The Journal of clinical endocrinology and metabolism.

[61]  P. Vestergaard,et al.  Impact of GH administration on athletic performance in healthy young adults: A systematic review and meta-analysis of placebo-controlled trials. , 2017, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[62]  T. Zhu,et al.  Autocrine Human Growth Hormone Promotes Invasive and Cancer Stem Cell-Like Behavior of Hepatocellular Carcinoma Cells by STAT3 Dependent Inhibition of CLAUDIN-1 Expression , 2017, International journal of molecular sciences.

[63]  R. Subramani,et al.  Role of Growth Hormone in Breast Cancer , 2017, Endocrinology.

[64]  M. Bondanelli,et al.  Growth Hormone differentially modulates chemoresistance in human endometrial adenocarcinoma cell lines , 2017, Endocrine.

[65]  S. Smaniotto,et al.  Growth hormone modulates in vitro endothelial cell migration and formation of capillary‐like structures , 2017, Cell biology international.

[66]  Z. Canturk,et al.  Matrix metalloproteinase 2 (MMP-2) levels are increased in active acromegaly patients , 2017, Endocrine.

[67]  Shiyong Wu,et al.  Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps , 2017, Hormones and Cancer.

[68]  Z. Ungvari,et al.  The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer , 2017, GeroScience.

[69]  Shiyong Wu,et al.  Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways , 2017, Oncotarget.

[70]  M. Bredella,et al.  The Association Between IGF-1 Levels and the Histologic Severity of Nonalcoholic Fatty Liver Disease , 2017, Clinical and Translational Gastroenterology.

[71]  W. Fu,et al.  Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice , 2016, BMC Cancer.

[72]  Richard A. Miller,et al.  mTOR regulates the expression of DNA damage response enzymes in long‐lived Snell dwarf, GHRKO, and PAPPA‐KO mice , 2016, Aging cell.

[73]  H. Sørensen,et al.  Acromegaly incidence, prevalence, complications and long-term prognosis: a nationwide cohort study. , 2016, European journal of endocrinology.

[74]  W. Wilson,et al.  Growth hormone receptor antagonism suppresses tumour regrowth after radiotherapy in an endometrial cancer xenograft model. , 2016, Cancer letters.

[75]  N. Barzilai,et al.  The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research. , 2016, Cell metabolism.

[76]  P. Delafontaine,et al.  Insulin-Like Growth Factor-1 Receptor Deficiency in Macrophages Accelerates Atherosclerosis and Induces an Unstable Plaque Phenotype in Apolipoprotein E–Deficient Mice , 2016, Circulation.

[77]  S. Yakar,et al.  Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models. , 2016, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[78]  S. Melmed,et al.  Growth hormone is permissive for neoplastic colon growth , 2016, Proceedings of the National Academy of Sciences.

[79]  G. Davis,et al.  TIMP3 Modulates GHR Abundance and GH Sensitivity. , 2016, Molecular endocrinology.

[80]  Yi-ran Huang,et al.  Dysregulation and functional roles of miR-183-96-182 cluster in cancer cell proliferation, invasion and metastasis , 2016, Oncotarget.

[81]  J. Kopchick,et al.  Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice. , 2016, Endocrinology.

[82]  A. Bartke,et al.  Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence , 2016, Cell reports.

[83]  A. Pezeshki,et al.  Naturally occurring p16Ink4a-positive cells shorten healthy lifespan , 2016, Nature.

[84]  E. Puré,et al.  Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice* , 2015, The Journal of Biological Chemistry.

[85]  S. Yamada,et al.  Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence , 2015, PloS one.

[86]  L. Kasuki,et al.  Low Frequency of Cardiomyopathy Using Cardiac Magnetic Resonance Imaging in an Acromegaly Contemporary Cohort. , 2015, The Journal of clinical endocrinology and metabolism.

[87]  T. Zhu,et al.  Autocrine human growth hormone stimulates the tumor initiating capacity and metastasis of estrogen receptor-negative mammary carcinoma cells. , 2015, Cancer letters.

[88]  W. Mitch,et al.  Protective role of insulin-like growth factor-1 receptor in endothelial cells against unilateral ureteral obstruction-induced renal fibrosis. , 2015, The American journal of pathology.

[89]  M. Zhang,et al.  Autocrine/Paracrine Human Growth Hormone-stimulated MicroRNA 96-182-183 Cluster Promotes Epithelial-Mesenchymal Transition and Invasion in Breast Cancer* , 2015, The Journal of Biological Chemistry.

[90]  Joseph M Pappachan,et al.  Excess mortality associated with hypopituitarism in adults: a meta-analysis of observational studies. , 2015, The Journal of clinical endocrinology and metabolism.

[91]  R. Subramani,et al.  Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma , 2014, Experimental & Molecular Medicine.

[92]  Da Ma,et al.  Expression of insulin-like growth factor-1 receptor in keloid and hypertrophic scar , 2014, Clinical and experimental dermatology.

[93]  A. Oberg,et al.  Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice , 2014, Aging.

[94]  Xiao-yu Wu,et al.  Growth hormone protects colorectal cancer cells from radiation by improving the ability of DNA damage repair. , 2014, Molecular medicine reports.

[95]  K. Karason,et al.  GH and the cardiovascular system: an update on a topic at heart , 2014, Endocrine.

[96]  S. Pinder,et al.  Growth Hormone Is Secreted by Normal Breast Epithelium upon Progesterone Stimulation and Increases Proliferation of Stem/Progenitor Cells , 2014, Stem cell reports.

[97]  Yimin Fang,et al.  Downregulation of the ACE2/Ang-(1-7)/Mas axis in transgenic mice overexpressing GH. , 2014, The Journal of endocrinology.

[98]  Z. Xiao,et al.  Insulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence , 2014, Aging cell.

[99]  P. Chanson,et al.  Growth hormone, insulin-like growth factor-1, and the kidney: pathophysiological and clinical implications. , 2014, Endocrine reviews.

[100]  J. Kopchick,et al.  Elevated systolic blood pressure in male GH transgenic mice is age dependent. , 2014, Endocrinology.

[101]  T. Martinussen,et al.  Chronic alterations in growth hormone/insulin-like growth factor-I signaling lead to changes in mouse tendon structure. , 2014, Matrix biology : journal of the International Society for Matrix Biology.

[102]  Hisashi Adachi,et al.  Inflammation, atherosclerosis, and coronary artery disease. , 2005, The New England journal of medicine.

[103]  S. Melmed,et al.  Growth hormone is a cellular senescence target in pituitary and nonpituitary cells , 2013, Proceedings of the National Academy of Sciences.

[104]  L. Hilsted,et al.  Central hypothyroidism and its replacement have a significant influence on cardiovascular risk factors in adult hypopituitary patients. , 2013, The Journal of clinical endocrinology and metabolism.

[105]  G. Johannsson,et al.  The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations , 2013, Nature Reviews Endocrinology.

[106]  T. Zhu,et al.  Autocrine human GH promotes radioresistance in mammary and endometrial carcinoma cells. , 2012, Endocrine-related cancer.

[107]  N. Yuldasheva,et al.  Novel Role of the IGF-1 Receptor in Endothelial Function and Repair , 2012, Diabetes.

[108]  R. Kitazawa,et al.  Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy. , 2012, European journal of endocrinology.

[109]  D. Molè,et al.  Growth hormone receptor blockade inhibits growth hormone-induced chemoresistance by restoring cytotoxic-induced apoptosis in breast cancer cells independently of estrogen receptor expression. , 2012, The Journal of clinical endocrinology and metabolism.

[110]  E. Sanders,et al.  Extrapituitary production of anterior pituitary hormones: an overview , 2012, Endocrine.

[111]  M. Barcellos-Hoff,et al.  The pivotal role of insulin-like growth factor I in normal mammary development. , 2011, Endocrinology and metabolism clinics of North America.

[112]  Helen H. W. Chen,et al.  Autocrine human growth hormone reduces mammary and endometrial carcinoma cell sensitivity to mitomycin C. , 2011, Oncology reports.

[113]  Afroze Abbas,et al.  The Insulin-Like Growth Factor-1 Receptor Is a Negative Regulator of Nitric Oxide Bioavailability and Insulin Sensitivity in the Endothelium , 2011, Diabetes.

[114]  M. Kjaer,et al.  GH receptor blocker administration and muscle-tendon collagen synthesis in humans. , 2011, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[115]  P. Chanson,et al.  Body fluid expansion in acromegaly is related to enhanced epithelial sodium channel (ENaC) activity. , 2011, The Journal of clinical endocrinology and metabolism.

[116]  Z. Laron,et al.  Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. , 2011, European journal of endocrinology.

[117]  M. Gleave,et al.  Human prostate cancer xenografts in lit/lit mice exhibit reduced growth and androgen‐independent progression , 2011, The Prostate.

[118]  M. Leslie.  Genetics and disease. Growth defect blocks cancer and diabetes. , 2011, Science.

[119]  Federica Madia,et al.  Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans , 2011, Science Translational Medicine.

[120]  G. Vitale,et al.  Thyroid nodules in acromegaly: The role of elastography. , 2010, Journal of ultrasound.

[121]  E. Monti,et al.  GH in combination with bisphosphonate treatment in osteogenesis imperfecta. , 2010, European journal of endocrinology.

[122]  Peter Kraft,et al.  Pathway analysis of breast cancer genome-wide association study highlights three pathways and one canonical signaling cascade. , 2010, Cancer research.

[123]  Y. Lee,et al.  The effect of growth hormone on fibroblast proliferation and keratinocyte migration. , 2010, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[124]  M. Kjaer,et al.  Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis , 2010, The Journal of physiology.

[125]  D. Molè,et al.  Growth hormone excess promotes breast cancer chemoresistance. , 2009, The Journal of clinical endocrinology and metabolism.

[126]  A. Bartke,et al.  Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[127]  B. Bengtsson,et al.  Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984. , 2009, Acta medica Scandinavica.

[128]  H. Orskov,et al.  A hyperkinetic heart in uncomplicated active acromegaly. Explanation of hypertension in acromegalic patients? , 2009, Acta medica Scandinavica.

[129]  Niels Møller,et al.  Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. , 2009, Endocrine reviews.

[130]  C. Print,et al.  Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma. , 2009, Endocrinology.

[131]  M. Pollak,et al.  Insulin and insulin-like growth factor signalling in neoplasia , 2008, Nature Reviews Cancer.

[132]  M. Losa,et al.  Effects of growth hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth hormone deficiency. , 2008, Metabolism: clinical and experimental.

[133]  J. Gibney,et al.  The effect of growth hormone replacement on exercise capacity in patients with GH deficiency: a metaanalysis. , 2008, The Journal of clinical endocrinology and metabolism.

[134]  D. Leroith,et al.  Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy. , 2008, Molecular endocrinology.

[135]  P. Gluckman,et al.  DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells , 2008, Oncogene.

[136]  P. Singal,et al.  Growth hormone in vascular pathology: neovascularization and expression of receptors is associated with cellular proliferation. , 2007, Anticancer research.

[137]  N. Rosenthal,et al.  Enhancing Repair of the Mammalian Heart , 2007, Circulation research.

[138]  P. Chanson,et al.  Impact of somatostatin analogs on the heart in acromegaly: a metaanalysis. , 2007, The Journal of clinical endocrinology and metabolism.

[139]  P. Poole‐Wilson,et al.  Age-Dependent Impairment of Endothelial Progenitor Cells Is Corrected by Growth Hormone Mediated Increase of Insulin-Like Growth Factor-1 , 2007, Circulation research.

[140]  P. Gluckman,et al.  αCP1 Mediates Stabilization of hTERT mRNA by Autocrine Human Growth Hormone* , 2007, Journal of Biological Chemistry.

[141]  S. Melmed,et al.  Skin manifestations in acromegaly. , 2006, Clinics in dermatology.

[142]  Jie-shou Li,et al.  Growth hormone receptor overexpression predicts response of rectal cancers to pre-operative radiotherapy. , 2006, European journal of cancer.

[143]  Adrian V. Lee,et al.  The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth , 2006, Breast Cancer Research and Treatment.

[144]  V. Ray,et al.  Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse. , 2005, Endocrinology.

[145]  Carmen Z. Michaylira,et al.  Suppressor of cytokine signaling-2 modulates the fibrogenic actions of GH and IGF-I in intestinal mesenchymal cells. , 2005, American journal of physiology. Gastrointestinal and liver physiology.

[146]  R. Lanes,et al.  Endothelial function, carotid artery intima-media thickness, epicardial adipose tissue, and left ventricular mass and function in growth hormone-deficient adolescents: apparent effects of growth hormone treatment on these parameters. , 2005, The Journal of clinical endocrinology and metabolism.

[147]  R. Sartor,et al.  Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation. , 2005, Gastroenterology.

[148]  L. Lönn,et al.  Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial. , 2005, The Journal of clinical endocrinology and metabolism.

[149]  P. Gluckman,et al.  Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. , 2005, Cancer research.

[150]  P. Gluckman,et al.  Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[151]  M. Waters,et al.  The oncogenic potential of autocrine human growth hormone in breast cancer. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[152]  T. Wynn.  Fibrotic disease and the TH1/TH2 paradigm , 2004, Nature Reviews Immunology.

[153]  D. Chinkes,et al.  Growth hormone effects on hypertrophic scar formation: a randomized controlled trial of 62 burned children , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[154]  F. Bogazzi,et al.  Growth hormone inhibits apoptosis in human colonic cancer cell lines: antagonistic effects of peroxisome proliferator activated receptor-gamma ligands. , 2004, Endocrinology.

[155]  I. Thorey,et al.  Transgenic Mice Reveal Novel Activities of Growth Hormone in Wound Repair, Angiogenesis, and Myofibroblast Differentiation* , 2004, Journal of Biological Chemistry.

[156]  H. Randeva,et al.  Growth Hormone Replacement Decreases Plasma Levels of Matrix Metalloproteinases (2 and 9) and Vascular Endothelial Growth Factor in Growth Hormone–Deficient Individuals , 2004, Circulation.

[157]  E. Levtchenko,et al.  Growth hormone therapy influences endothelial function in children with renal failure , 2004, Pediatric Nephrology.

[158]  P. Chanson,et al.  Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: a Metaanalysis of Blinded, Randomized, Placebo-Controlled Trials. , 2004, The Journal of clinical endocrinology and metabolism.

[159]  M. Nakashima,et al.  GH suppresses TGF-β-mediated fibrosis and retains cardiac diastolic function , 2004, Molecular and Cellular Endocrinology.

[160]  R. Arnold,et al.  The Inhibition of Apoptosis in EL4 Lymphoma Cells Overexpressing Growth Hormone , 2004, Neuroimmunomodulation.

[161]  W. Drake,et al.  Pegvisomant: a novel pharmacotherapy for the treatment of acromegaly , 2004, Expert opinion on biological therapy.

[162]  M. Elam,et al.  The effect of growth hormone (GH) replacement therapy on sympathetic nerve hyperactivity in hypopituitary adults: a double-blind, placebo-controlled, crossover, short-term trial followed by long-term open GH replacement in hypopituitary adults , 2003, Journal of hypertension.

[163]  O. Wiklund,et al.  Increased Interleukin‐6 levels in pituitary‐deficient patients are independently related to their carotid intima‐media thickness , 2003, Clinical endocrinology.

[164]  R. Napoli,et al.  Acute effects of growth hormone on vascular function in human subjects. , 2003, The Journal of clinical endocrinology and metabolism.

[165]  Tao Zhu,et al.  Human Growth Hormone-regulated HOXA1 Is a Human Mammary Epithelial Oncogene* , 2003, The Journal of Biological Chemistry.

[166]  C. Drake.  Embryonic and adult vasculogenesis. , 2003, Birth Defects Research Part C Embryo Today Reviews.

[167]  V. Esposito,et al.  Impact of successful transsphenoidal surgery on cardiovascular risk factors in acromegaly. , 2003, European journal of endocrinology.

[168]  T. Unterman,et al.  The growth hormone-deficient Spontaneous Dwarf rat is resistant to chemically induced mammary carcinogenesis. , 2002, Carcinogenesis.

[169]  L. Ellegård,et al.  GH increases extracellular volume by stimulating sodium reabsorption in the distal nephron and preventing pressure natriuresis. , 2002, The Journal of clinical endocrinology and metabolism.

[170]  N. Drinkwater,et al.  The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility. , 2001, Carcinogenesis.

[171]  G. Morel,et al.  Autocrine Human Growth Hormone (hGH) Regulation of Human Mammary Carcinoma Cell Gene Expression , 2001, The Journal of Biological Chemistry.

[172]  K. Snibson,et al.  Overexpressed growth hormone (GH) synergistically promotes carcinogen-initiated liver tumour growth by promoting cellular proliferation in emerging hepatocellular neoplasms in female and male GH-transgenic mice. , 2001, Liver.

[173]  J. A. Scarlett,et al.  Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice. , 2001, Journal of neurosurgery.

[174]  K. Wheatley,et al.  Association between premature mortality and hypopituitarism , 2001, The Lancet.

[175]  P. Cohen,et al.  Does the GH-IGF axis play a role in cancer pathogenesis? , 2000, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[176]  N. Rifai,et al.  Effects of Growth Hormone Administration on Inflammatory and Other Cardiovascular Risk Markers in Men with Growth Hormone Deficiency , 2000, Annals of Internal Medicine.

[177]  W. Sluiter,et al.  Effect of growth hormone replacement therapy on plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities in growth hormone-deficient adults. , 2000, Journal of lipid research.

[178]  P. Ridker,et al.  C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. , 2000, The New England journal of medicine.

[179]  S. Jackson,et al.  The effect of GH replacement therapy on endothelial function and oxidative stress in adult growth hormone deficiency. , 2000, European journal of endocrinology.

[180]  J. Jørgensen,et al.  Insulin‐like growth factor I administration induces fluid and sodium retention in healthy adults: possible involvement of renin and atrial natriuretic factor , 2000, Clinical endocrinology.

[181]  G. Morel,et al.  Autocrine stimulation of human mammary carcinoma cell proliferation by human growth hormone. , 1999, Experimental cell research.

[182]  R. Radinsky,et al.  Growth hormone receptor expression and function in meningiomas: effect of a specific receptor antagonist. , 1999, Journal of neurosurgery.

[183]  M. Brandon,et al.  High, persistent hepatocellular proliferation and apoptosis precede hepatocarcinogenesis in growth hormone transgenic mice. , 1999, Liver.

[184]  R. Busse,et al.  Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells. , 1999, Cardiovascular research.

[185]  M. Elam,et al.  Intense sympathetic nerve activity in adults with hypopituitarism and untreated growth hormone deficiency. , 1998, The Journal of clinical endocrinology and metabolism.

[186]  G. Grimby,et al.  Two years of growth hormone (GH) treatment increase isometric and isokinetic muscle strength in GH-deficient adults. , 1997, The Journal of clinical endocrinology and metabolism.

[187]  Lois E. H. Smith,et al.  Essential role of growth hormone in ischemia-induced retinal neovascularization. , 1997, Science.

[188]  N. Møller,et al.  Blockade of the renin-angiotensin-aldosterone system prevents growth hormone-induced fluid retention in humans. , 1997, The American journal of physiology.

[189]  G. Striker,et al.  Differential expression of glomerular extracellular matrix and growth factor mRNA in rapid and slowly progressive glomerulosclerosis: studies in mice transgenic for native or mutated growth hormone. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[190]  G. Brabant,et al.  Nitric oxide may mediate the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency. A double-blind, placebo-controlled study. , 1996, The Journal of clinical investigation.

[191]  M. Kendall,et al.  Growth hormone treatment for growth hormone deficient adults , 1996, Journal of clinical pharmacy and therapeutics.

[192]  J. Jørgensen,et al.  Decreased plasma and extracellular volume in growth hormone deficient adults and the acute and prolonged effects of GH administration: a controlled experimental study. , 1996, Clinical endocrinology.

[193]  R. Muniyappa,et al.  Insulin-like growth factor I diminishes in vivo and in vitro vascular contractility: role of vascular nitric oxide. , 1996, Endocrinology.

[194]  A. Vaag,et al.  Insulin resistance in growth hormone-deficient adults: defects in glucose utilization and glycogen synthase activity. , 1996, The Journal of clinical endocrinology and metabolism.

[195]  J. Jørgensen,et al.  Body fluids, circadian blood pressure and plasma renin during growth hormone administration: a placebo-controlled study with two growth hormone doses in healthy adults. , 1995, Scandinavian journal of clinical and laboratory investigation.

[196]  B. Bengtsson,et al.  Growth hormone-deficient adults are insulin-resistant. , 1995, Metabolism: clinical and experimental.

[197]  B. Kristensen,et al.  Short and long‐term cardiovascular effects of growth hormone therapy in growth hormone deficient adults , 1994, Clinical endocrinology.

[198]  H. Wåhlander,et al.  Increased expression of growth hormone receptor mRNA and insulin-like growth factor-I mRNA in volume-overloaded hearts. , 1994, Hypertension.

[199]  C. Carella,et al.  Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. , 1993, The Journal of clinical endocrinology and metabolism.

[200]  B. Angelin,et al.  Increased concentrations of serum lipoprotein (a) in response to growth hormone treatment. , 1993, BMJ.

[201]  I. Bosaeus,et al.  Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency , 1993, Clinical endocrinology.

[202]  M. Elam,et al.  In vivo growth hormone treatment stimulates secretion of very low density lipoprotein by the isolated perfused rat liver. , 1992, Endocrinology.

[203]  J. Gustafsson,et al.  Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[204]  K. Alberti,et al.  Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy. , 1992, The Journal of clinical endocrinology and metabolism.

[205]  J. Jansson,et al.  Growth hormone stimulates granulation tissue formation and insulin-like growth factor-I gene expression in wound chambers in the rat. , 1992, The Journal of endocrinology.

[206]  C. Wiles,et al.  Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. , 1991, Journal of applied physiology.

[207]  P. Chomczyński,et al.  Human growth hormone stimulates proliferation of human retinal microvascular endothelial cells in vitro. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[208]  B. Bengtsson,et al.  Premature mortality due to cardiovascular disease in hypopituitarism , 1990, The Lancet.

[209]  M. Sonenberg,et al.  Growth hormone-dependent events in the adipose differentiation of 3T3-F442A fibroblasts: modulation of macromolecular synthesis. , 1989, Endocrinology.

[210]  N. Skakkebaek,et al.  BENEFICIAL EFFECTS OF GROWTH HORMONE TREATMENT IN GH-DEFICIENT ADULTS , 1989, The Lancet.

[211]  H. Orskov,et al.  Increased myocardial contractility following growth hormone administration in normal man. An echocardiographic study. , 1988, Danish medical bulletin.

[212]  M. Genel,et al.  RISK OF HYPOGLYCAEMIA WITH ALTERNATE-DAY GROWTH HORMONE INJECTIONS , 1987, The Lancet.

[213]  J. Lie,et al.  Pathology of the heart in acromegaly: anatomic findings in 27 autopsied patients. , 1980, American heart journal.

[214]  D. Robertson,et al.  PITUITARY ABLATION FOR DIABETIC RETINOPATHY , 1966, Mayo Clinic proceedings.

[215]  K. Zierler,et al.  ROLES OF INSULIN AND GROWTH HORMONE, BASED ON STUDIES ON FOREARM METABOLISM IN MAN , 1963, Medicine.

[216]  R. Luft,et al.  Body water and sodium in patients with acromegaly. , 1954, The Journal of clinical investigation.

[217]  B. Houssay.  The Hypophysis and Metabolism , 1936 .

[218]  M. Vendelbo,et al.  Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes. , 2019, American journal of physiology. Endocrinology and metabolism.

[219]  M. Bergsneider,et al.  NO BENEFIT OF DEDICATED THYROID NODULE SCREENING IN PATIENTS WITH ACROMEGALY. , 2019, Endocrine Practice.

[220]  J. Jørgensen,et al.  Fibroblast activation protein is a GH target: A prospective study of patients with acromegaly before and after treatment. , 2019, The Journal of clinical endocrinology and metabolism.

[221]  N. Åberg,et al.  Growth Hormone Improves Cognitive Function After Experimental Stroke , 2018, Stroke.

[222]  髙原 健.  Human prostate cancer xenografts in lit/lit mice exhibit reduced growth and androgen-independent progression , 2013 .

[223]  W. Tuinebreijer,et al.  Recombinant human growth hormone for treating burns and donor sites. , 2012, The Cochrane database of systematic reviews.

[224]  G. McCaughan,et al.  Fibroblast activation protein and chronic liver disease. , 2008, Frontiers in bioscience : a journal and virtual library.

[225]  V. Ray,et al.  Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling. , 2007, Carcinogenesis.

[226]  T. Wynn.  Fibrotic disease and the T(H)1/T(H)2 paradigm. , 2004, Nature reviews. Immunology.

[227]  K. Wheatley,et al.  Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. , 2001, Lancet.

[228]  J. Terwilliger,et al.  Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. , 2001, Developmental biology.

[229]  N. Rifai,et al.  Effects of growth hormone administration on inflammatory and other cardiovascular risk markers in men with growth hormone deficiency. A randomized, controlled clinical trial. , 2000, Annals of internal medicine.

[230]  P. Clayton,et al.  Human skin fibroblasts as a model of growth hormone (GH) action in GH receptor-positive Laron's syndrome. , 1997, Endocrinology.

[231]  R. Palmiter,et al.  Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1. , 1988, The American journal of pathology.

[232]  C. Li,et al.  Neoplasms in rats treated with pituitary growth hormone; pulmonary and lymphatic tissues. , 1950, Cancer research.