Wnt signaling and human diseases: what are the therapeutic implications?
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T. He | H. Luu | Z. Deng | K. Sharff | Ni Tang | Wen-Xin Song | Jinyong Luo | Xiaoji Luo | Jin Chen | R. Haydon
[1] A. Montag,et al. CCN1/Cyr61 Is Regulated by the Canonical Wnt Signal and Plays an Important Role in Wnt3A-Induced Osteoblast Differentiation of Mesenchymal Stem Cells , 2006, Molecular and Cellular Biology.
[2] C. Hartmann. A Wnt canon orchestrating osteoblastogenesis. , 2006, Trends in cell biology.
[3] S. O’Rahilly,et al. WNT10B mutations in human obesity , 2006, Diabetologia.
[4] Randall T. Moon,et al. Wnt and calcium signaling: β-Catenin-independent pathways , 2005 .
[5] W. Birchmeier,et al. The role of Axin2 in calvarial morphogenesis and craniosynostosis , 2005, Development.
[6] H. Clevers,et al. Wnt signalling in stem cells and cancer , 2005, Nature.
[7] Wei Jiang,et al. Wnt/beta-catenin signaling pathway as a novel cancer drug target. , 2004, Current cancer drug targets.
[8] Ajamete Kaykas,et al. WNT and β-catenin signalling: diseases and therapies , 2004, Nature Reviews Genetics.
[9] L. Southam,et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[10] J. Nathans,et al. Frizzled6 controls hair patterning in mice. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[11] I. Thesleff,et al. Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer. , 2004, American journal of human genetics.
[12] J. Healey,et al. Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. , 2004, Cancer research.
[13] Michael J Parker,et al. Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. , 2004, American journal of human genetics.
[14] E. Fuchs,et al. Socializing with the Neighbors Stem Cells and Their Niche , 2004, Cell.
[15] Chengfeng Zhao,et al. Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family. , 2004, American journal of human genetics.
[16] R. White,et al. Targeted degradation of β-catenin by chimeric F-box fusion proteins , 2004 .
[17] H. Macdonald,et al. β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis , 2004, The Journal of experimental medicine.
[18] F. Zhan,et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. , 2003, The New England journal of medicine.
[19] H. Ujike,et al. The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia , 2003, Neuroscience Letters.
[20] T. Couffinhal,et al. Reduction of Infarct Size and Prevention of Cardiac Rupture in Transgenic Mice Overexpressing FrzA , 2003, Circulation.
[21] A. Bradley,et al. Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. , 2003, Cancer cell.
[22] Haiyang Huang,et al. Identification of the haematopoietic stem cell niche and control of the niche size , 2003, Nature.
[23] S. Ishikawa,et al. Eradication of pathogenic β-catenin by Skp1/Cullin/F box ubiquitination machinery , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[24] H. Varmus,et al. A protein knockdown strategy to study the function of β-catenin in tumorigenesis , 2003, BMC Molecular Biology.
[25] E. Vilain,et al. Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/β-catenin synergy , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[26] Michael D. Schneider,et al. Sizing up the heart: development redux in disease. , 2003, Genes & development.
[27] A. Perantoni. Renal development: perspectives on a Wnt-dependent process. , 2003, Seminars in cell & developmental biology.
[28] B. Alman,et al. Beta-catenin expression in Dupuytren's disease: potential role for cell–matrix interactions in modulating beta-catenin levels in vivo and in vitro , 2003, Oncogene.
[29] K Oshima,et al. Frizzled 4 gene (FZD4) mutations in patients with familial exudative vitreoretinopathy with variable expressivity , 2003, The British journal of ophthalmology.
[30] Andrea Caricasole,et al. The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease? , 2003, Trends in pharmacological sciences.
[31] J. Szatkowski,et al. Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity. , 2003, Cancer letters.
[32] R. Surabhi,et al. Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[33] L. Hofbauer,et al. High bone density due to a mutation in LDL-receptor-related protein 5. , 2002, The New England journal of medicine.
[34] M. R. Islam,et al. The Polycystic Kidney Disease-1 Promoter Is a Target of the β-Catenin/T-cell Factor Pathway* , 2002, The Journal of Biological Chemistry.
[35] M. Hayden,et al. Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy , 2002, Nature Genetics.
[36] M. Daemen,et al. The wnt-frizzled cascade in cardiovascular disease. , 2002, Cardiovascular research.
[37] M. Oshimura,et al. Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin. , 2002, Cancer research.
[38] Richard P Lifton,et al. High bone density due to a mutation in LDL-receptor-related protein 5. , 2002, The New England journal of medicine.
[39] Hans Clevers,et al. β-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[40] R. Belmaker,et al. GSK-3 and the neurodevelopmental hypothesis of schizophrenia , 2002, European Neuropsychopharmacology.
[41] Simon Lovestone,et al. Alzheimer's disease – do tauists and baptists finally shake hands? , 2002, Trends in Neurosciences.
[42] M. Sakaguchi,et al. Antiproliferative activity of REIC/Dkk-3 and its significant down-regulation in non-small-cell lung carcinomas. , 2001, Biochemical and biophysical research communications.
[43] Miikka Vikkula,et al. LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development , 2001, Cell.
[44] W. Weis,et al. β-catenin: molecular plasticity and drug design , 2001 .
[45] Bert Vogelstein,et al. Combinatorial chemoprevention of intestinal neoplasia , 2000, Nature Medicine.
[46] C. Hartmann,et al. Dual roles of Wnt signaling during chondrogenesis in the chicken limb. , 2000, Development.
[47] K. Kinzler,et al. The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression. , 2000, Cancer research.
[48] Yusuke Nakamura,et al. AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 , 2000, Nature Genetics.
[49] G. Cossu,et al. Wnt signaling and the activation of myogenesis in mammals , 1999, The EMBO journal.
[50] P. Morin,et al. β‐catenin signaling and cancer , 1999 .
[51] K. Kinzler,et al. PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs , 1999, Cell.
[52] Tsuyoshi Miyaoka,et al. Increased expression of Wnt-1 in schizophrenic brains , 1999, Schizophrenia Research.
[53] Paul Polakis,et al. The oncogenic activation of β-catenin , 1999 .
[54] A. Sparks,et al. Identification of c-MYC as a target of the APC pathway. , 1998, Science.
[55] Hans Clevers,et al. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4 , 1998, Nature Genetics.
[56] K. Kinzler,et al. Lessons from Hereditary Colorectal Cancer , 1996, Cell.
[57] E. Fuchs,et al. Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. , 1995, Genes & development.
[58] I Fariñas,et al. Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. , 1994, Genes & development.
[59] Harold E. Varmus,et al. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome , 1982, Cell.
[60] H. Clevers. Wnt/beta-catenin signaling in development and disease. , 2006, Cell.
[61] Randall T Moon,et al. Wnt and calcium signaling: beta-catenin-independent pathways. , 2005, Cell calcium.
[62] Frank Petersen,et al. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. , 2004, Cancer cell.
[63] Raymond L. White,et al. Targeted degradation of beta-catenin by chimeric F-box fusion proteins. , 2004, Biochemical and biophysical research communications.
[64] Randall T Moon,et al. WNT and beta-catenin signalling: diseases and therapies. , 2004, Nature reviews. Genetics.
[65] Frank Petersen,et al. Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex , 2004 .
[66] Mark L. Johnson,et al. A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. , 2002, American journal of human genetics.
[67] W. Weis,et al. beta-catenin: molecular plasticity and drug design. , 2001, Trends in biochemical sciences.
[68] K. Kinzler,et al. PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. , 1999, Cell.
[69] P. Polakis. The oncogenic activation of beta-catenin. , 1999, Current opinion in genetics & development.
[70] F. McCormick,et al. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. , 1999, Nature.
[71] P. Morin,et al. beta-catenin signaling and cancer. , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.
[72] D. J. Van Den Berg,et al. Role of members of the Wnt gene family in human hematopoiesis. , 1998, Blood.
[73] H Clevers,et al. Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. , 1998, Immunity.
[74] R. Nusse,et al. Mechanisms of Wnt signaling in development. , 1998, Annual review of cell and developmental biology.