Genital vitiligo-like depigmentation following use of imiquimod 5 % cream Imiquimod

342 d o i : 10.84/ejd .208.0402 Most authors recommend a quick freeze and slow thaw method of tissue destruction. Slow cooling produces extracellular ice, but this is not as damaging as rapid cooling that produces intracellular ice formation. With slow thawing, an increased concentration of electrolytes and recrystallization occurs, which is also damaging to cells. Thus the rate of rewarming, or thaw, should proceed slowly [1]. Cryoblasting successfully achieves the quick freeze and slow thaw desired for destruction of thicker lesions. To our current knowledge, there is only one previous report related to cryoblast for verrucae [2]. Callaway et al. showed that cryoblast can achieve a deeper ice ball compared with classic cryosurgery on a gelatin model [2]. Cryoblast is a technique which has a short duration of freeze giving pain relief and no difference of complications compared with classical methods. In the present study, we showed that cryoblast is signifi cantly more effective than cryo-spray. Although we expected more scarring with cryoblasting, there was no difference from the scarring resulting from cryo-spray, as in the previous study [2]. Cryoblast could be an alternative method in the treatment of plantar verrucae. Controlled trials comparing cryoblast to cryospray are recommended for further confi rmation. Acknowledgements. Financial support: none. Confl ict of interest: None.