Thermally enhanced oil recovery methods, such as in situ combustion and steam injection, are generating considerable interest in terms of improving oil reserve exploitation and satisfying oil demand and economic growth. However, the early breakthrough of the in situ combustion front and the significant amount of heat loss associated with steam injection for deeper reservoir applications are the main challenges that require urgent solutions. Further data collection related to the effects of a reservoir’s physical and chemical properties, temperature, and pressure on in situ combustion front propagation and steam injection heat transfer inefficiency would be needed to achieve better reservoir oil recovery. Most studies have focused on the application of catalytic systems and the investigation of minerals’ effects on combustion front stabilization; however, the effect of clay interlayers’ minerals on the performance of in situ combustion is still poorly understood. This paper takes a new look at the role played by the interlayers’ minerals in stabilizing the combustion front using X-ray diffraction (XRD), thermogravimetry (TG), differential scanning calorimetry (DSC) combined with nuclear magnetic resonance (NMR), and combustion tube experiments. The studied samples’ compositions were analyzed by XRD, TG/DSC, and NMR techniques. Meanwhile, the effects of interlayers’ minerals on oil production were screened by combustion tube experiments. The data obtained from this study suggest that clay dispersion within a reservoir would improve oil recovery via in situ combustion, and our study led us to obtain an 80.5% recovery factor. However, the experiments of models with clay interlayers showed less recovery factors, and the model with interlayers led to a 0% recovery factor in the presence of air injection. Meanwhile, the same model in hydrothermal and air injection conditions led to a 13.9% recovery factor. This was due to the hydrothermal effect improving permeability and pore enlargement, which allowed the transfer of heat and matter. Moreover, our study found that clay minerals exhibit excellent catalytic effects on the formation of fuel deposition and the coke oxidation process. This effect was reflected in the significant role played by clay minerals in decreasing the number of heteroatoms by breaking down the C-S, C-N, and C-O bonds and by stimulating the processes of hydrocarbon polymerization during the in situ combustion. Our results add to a growing body of literature related to in situ combustion challenges and underline the importance of a reservoir’s physical parameters in the successful application of in situ combustion.