An approach to quantifying the interaction between behavioural and transmission clusters: the case of Hepatitis C virus infections in HIV positive men who have sex with men

We hypothesize that patterns of sexual behaviour play a role in the conformation of transmission networks. If that was the case, behavioural grouping might in turn correlate with transmission networks and have the potential to predict proximity in viral phylogenies. To address this hypothesis, we present an intuitive approach for quantifying interactions between clusters of sexual behaviour along a virus phylogeny. Data from the Swiss HIV Cohort Study on condom use and incident Hepatitis C virus (HCV) sequences served as proof-of-concept. A strict inclusion criteria contrasting with relatively low HCV prevalence hindered our ability to identify significant relationships. This manuscript intends to serve as guide for studies aimed at characterizing interactions between behavioural patterns and transmission networks. Large transmission networks such as those of HIV or COVID-19 are prime candidates for applying this methodological approach.

[1]  H. Günthard,et al.  Phylogenetic Cluster Analysis Identifies Virological and Behavioral Drivers of HIV Transmission in MSM. , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  E. Bernasconi,et al.  Chemsex drugs on the rise: a longitudinal analysis of the Swiss HIV Cohort Study from 2007 to 2017 , 2019, HIV medicine.

[3]  Hansjakob Furrer,et al.  Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study , 2019, The Lancet.

[4]  H. Günthard,et al.  Clusters of sexual behaviour in HIV-positive men who have sex with men reveal highly dissimilar time trends. , 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  A. Trkola,et al.  Changing Trends in International Versus Domestic HCV Transmission in HIV-Positive Men Who Have Sex With Men: A Perspective for the Direct-Acting Antiviral Scale-Up Era , 2019, The Journal of infectious diseases.

[6]  Robert W Eisinger,et al.  HIV Viral Load and Transmissibility of HIV Infection: Undetectable Equals Untransmittable. , 2019, JAMA.

[7]  A. Trkola,et al.  High Number of Potential Transmitters Revealed in a Population-based Systematic Hepatitis C Virus RNA Screening Among Human Immunodeficiency Virus-infected Men Who Have Sex With Men , 2019, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8]  A. Trkola,et al.  High Cure Rates With Grazoprevir-Elbasvir With or Without Ribavirin Guided by Genotypic Resistance Testing Among Human Immunodeficiency Virus/Hepatitis C Virus–coinfected Men Who Have Sex With Men , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  H. Günthard,et al.  Quantifying the drivers of HIV transmission and prevention in men who have sex with men: a population model‐based analysis in Switzerland , 2018, HIV medicine.

[10]  M. Kretzschmar,et al.  Sexual risk behaviour trajectories among MSM at risk for HIV in Amsterdam, the Netherlands , 2018, AIDS.

[11]  C. Boucher,et al.  Declining Hepatitis C Virus (HCV) Incidence in Dutch Human Immunodeficiency Virus-Positive Men Who Have Sex With Men After Unrestricted Access to HCV Therapy , 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[12]  A. d’Arminio Monforte,et al.  Lack of decline in hepatitis C virus incidence among HIV-positive men who have sex with men during 1990-2014. , 2017, Journal of hepatology.

[13]  M. Egger,et al.  Hepatitis C virus transmission among human immunodeficiency virus‐infected men who have sex with men: Modeling the effect of behavioral and treatment interventions , 2016, Hepatology.

[14]  J. Gallant,et al.  Antiretroviral Therapy for the Prevention of HIV-1 Transmission. , 2016, The New England journal of medicine.

[15]  S. Dias,et al.  Implementation and Operational Research: Computer-Assisted Intervention for Safer Sex in HIV-Positive Men Having Sex With Men Findings of a European Randomized Multi-Center Trial , 2015, Journal of acquired immune deficiency syndromes.

[16]  M. Battegay,et al.  The HIV care cascade in Switzerland: reaching the UNAIDS/WHO targets for patients diagnosed with HIV , 2015, AIDS.

[17]  H. Günthard,et al.  Increases in Condomless Sex in the Swiss HIV Cohort Study , 2015, Open forum infectious diseases.

[18]  Y. Amirkhanian.  Social Networks, Sexual Networks and HIV Risk in Men Who Have Sex with Men , 2014, Current HIV/AIDS Reports.

[19]  A. Trkola,et al.  Resurgence of HIV Infection among Men Who Have Sex with Men in Switzerland: Mathematical Modelling Study , 2012, PloS one.

[20]  Alex Carballo-Diéguez,et al.  Successes and challenges of HIV prevention in men who have sex with men , 2012, The Lancet.

[21]  A. Rodger,et al.  Transmission of HCV in HIV-positive populations. , 2011, Current opinion in HIV and AIDS.

[22]  C. Roulin,et al.  Sexual Protection Behavior in HIV-Positive Gay Men: Testing a Modified Information-Motivation-Behavioral Skills Model , 2011, Archives of sexual behavior.

[23]  Enos Bernasconi,et al.  PERSONNES SEROPOSITIVES NE SOUFFRANT DAUCUNE AUTRE MST ET SUIVANT UN TRAITEMENT ANTIRETROVIRAL EFFICACE NE TRANSMETTENT PAS LE HIV PAR VOIE SEXUELLE , 2008 .

[24]  R. Weber,et al.  Unsafe sex and increased incidence of hepatitis C virus infection among HIV-infected men who have sex with men: the Swiss HIV Cohort Study. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.