Characterizations of particle size distribution of the droplets exhaled by sneeze

This work focuses on the size distribution of sneeze droplets exhaled immediately at mouth. Twenty healthy subjects participated in the experiment and 44 sneezes were measured by using a laser particle size analyser. Two types of distributions are observed: unimodal and bimodal. For each sneeze, the droplets exhaled at different time in the sneeze duration have the same distribution characteristics with good time stability. The volume-based size distributions of sneeze droplets can be represented by a lognormal distribution function, and the relationship between the distribution parameters and the physiological characteristics of the subjects are studied by using linear regression analysis. The geometric mean of the droplet size of all the subjects is 360.1 µm for unimodal distribution and 74.4 µm for bimodal distribution with geometric standard deviations of 1.5 and 1.7, respectively. For the two peaks of the bimodal distribution, the geometric mean (the geometric standard deviation) is 386.2 µm (1.8) for peak 1 and 72.0 µm (1.5) for peak 2. The influences of the measurement method, the limitations of the instrument, the evaporation effects of the droplets, the differences of biological dynamic mechanism and characteristics between sneeze and other respiratory activities are also discussed.

[1]  J. Seinfeld,et al.  Atmospheric Chemistry and Physics: From Air Pollution to Climate Change , 1997 .

[2]  J. F. Stampfer,et al.  Particle concentration in exhaled breath. , 1987, American Industrial Hygiene Association journal.

[3]  M. P. Wan,et al.  Dispersion of Expiratory Droplets in a General Hospital Ward with Ceiling Mixing Type Mechanical Ventilation System , 2007 .

[4]  Bin Zhao,et al.  Numerical study of the transport of droplets or particles generated by respiratory system indoors , 2004, Building and Environment.

[5]  R. Douglas,et al.  Assessment of experimental and natural viral aerosols. , 1966, Bacteriological reviews.

[6]  E. Mirgorodskaya,et al.  Effect of airway opening on production of exhaled particles. , 2010, Journal of applied physiology.

[7]  J. Duguid The Numbers and the Sites of Origin of the Droplets Expelled during Expiratory Activities , 1945, Edinburgh medical journal.

[8]  Shinhao Yang,et al.  The size and concentration of droplets generated by coughing in human subjects. , 2007, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[9]  Emil J. Hopfinger,et al.  Break-up and atomization of a round water jet by a high-speed annular air jet , 1998, Journal of Fluid Mechanics.

[10]  M. P. Wan,et al.  Transport and Removal of Expiratory Droplets in Hospital Ward Environment , 2008 .

[11]  Lidia Morawska,et al.  The mechanism of breath aerosol formation. , 2009, Journal of aerosol medicine and pulmonary drug delivery.

[12]  Cover Sheet DROPLET FATE IN INDOOR ENVIRONMENTS , OR CAN WE PREVENT THE SPREAD OF INFECTION ? , 2007 .

[13]  Peter V. Nielsen,et al.  Spatial Distribution of Infection Risk of SARS Transmission in a Hospital Ward , 2009 .

[14]  V. Knight,et al.  Human Influenza Resulting from Aerosol Inhalation , 1966, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[15]  C. Chao,et al.  A study of the dispersion of expiratory aerosols in unidirectional downward and ceiling-return type airflows using a multiphase approach. , 2006, Indoor air.

[16]  E Andres Houseman,et al.  Origin of exhaled breath particles from healthy and human rhinovirus-infected subjects. , 2011, Journal of aerosol medicine and pulmonary drug delivery.

[17]  D. Tyrrell,et al.  Experiments on the spread of colds: 1. Laboratory studies on the dispersal of nasal secretion , 1964, Journal of Hygiene.

[18]  Gerhard Scheuch,et al.  Inhaling to mitigate exhaled bioaerosols. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[19]  Jennifer Fiegel,et al.  Airborne infectious disease and the suppression of pulmonary bioaerosols , 2006, Drug Discovery Today.

[20]  Benjamin J. Cowling,et al.  Influenza Virus in Human Exhaled Breath: An Observational Study , 2008, PloS one.

[21]  K. Amighi,et al.  Formulation and Characterization of Lipid-Coated Tobramycin Particles for Dry Powder Inhalation , 2006, Pharmaceutical Research.

[22]  R. Loudon,et al.  Droplet expulsion from the respiratory tract. , 1967, The American review of respiratory disease.

[23]  M. P. Wan,et al.  Modeling the Fate of Expiratory Aerosols and the Associated Infection Risk in an Aircraft Cabin Environment , 2009 .

[24]  F. J. Miller,et al.  Particle inhalability curves for humans and small laboratory animals. , 1995, The Annals of occupational hygiene.

[25]  J. Niu,et al.  Transient CFD simulation of the respiration process and inter-person exposure assessment , 2005, Building and Environment.

[26]  Kerrie Mengersen,et al.  Modality of human expired aerosol size distributions , 2011 .

[27]  Yuguo Li,et al.  Exhaled droplets due to talking and coughing , 2009, Journal of The Royal Society Interface.

[28]  Kerrie Mengersen,et al.  Size distribution and sites of origin of droplets expelled from the human respiratory tract during expiratory activities , 2009 .

[29]  T R Bender,et al.  An outbreak of influenza aboard a commercial airliner. , 1979, American journal of epidemiology.

[30]  Y. Li,et al.  How far droplets can move in indoor environments--revisiting the Wells evaporation-falling curve. , 2007, Indoor air.

[31]  F S Rosenthal,et al.  The size distribution of droplets in the exhaled breath of healthy human subjects. , 1997, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[32]  T. J. Hanratty,et al.  Droplet size measurements in horizontal annular gas–liquid flow , 2001 .

[33]  A. Hubbard,et al.  Toward Understanding the Risk of Secondary Airborne Infection: Emission of Respirable Pathogens , 2005, Journal of occupational and environmental hygiene.

[34]  Chao-Hsin Lin,et al.  Characterizing exhaled airflow from breathing and talking. , 2010, Indoor air.

[35]  Mary-Louise McLaws,et al.  The role of particle size in aerosolised pathogen transmission: A review , 2010, Journal of Infection.

[36]  E. Robine,et al.  Impact of Health on Particle Size of Exhaled Respiratory Aerosols: Case‐control Study , 2008, Clean : soil, air, water.

[37]  Evert Ljungström,et al.  Size distribution of exhaled particles in the range from 0.01 to 2.0 μm , 2010 .

[38]  J. Duguid,et al.  The size and the duration of air-carriage of respiratory droplets and droplet-nuclei , 1946, Epidemiology and Infection.

[39]  K. Mengersen,et al.  Characterization of expiration air jets and droplet size distributions immediately at the mouth opening , 2008, Journal of Aerosol Science.

[40]  Mandip Singh,et al.  Evaluation of different parameters that affect droplet-size distribution from nasal sprays using the Malvern Spraytec. , 2004, Journal of pharmaceutical sciences.

[41]  P. Morrow PHYSICS OF AIRBORNE PARTICLES AND THEIR DEPOSITION IN THE LUNG * , 1980, Annals of the New York Academy of Sciences.

[42]  Duguid Jp,et al.  The Numbers and the Sites of Origin of the Droplets Expelled during Expiratory Activities , 1945, Edinburgh medical journal.

[43]  Chao-Hsin Lin,et al.  Flow dynamics and characterization of a cough. , 2009, Indoor air.

[44]  L. Morawska,et al.  Droplet fate in indoor environments, or can we prevent the spread of infection? , 2006, Indoor air.

[45]  L. Morawska,et al.  A review of dispersion modelling and its application to the dispersion of particles : An overview of different dispersion models available , 2006 .

[46]  K Leder,et al.  Respiratory infections during air travel , 2005, Internal medicine journal.

[47]  I. Orme,et al.  Cough-generated aerosols of Mycobacterium tuberculosis: a new method to study infectiousness. , 2004, American journal of respiratory and critical care medicine.

[48]  I. Larson,et al.  Agglomerate Strength and Dispersion of Salmeterol Xinafoate from Powder Mixtures for Inhalation , 2006, Pharmaceutical Research.

[49]  Z. Ristovski,et al.  Cough-generated aerosols of Pseudomonas aeruginosa and other Gram-negative bacteria from patients with cystic fibrosis , 2009, Thorax.

[50]  R B Couch,et al.  Effect of route of inoculation on experimental respiratory viral disease in volunteers and evidence for airborne transmission. , 1966, Bacteriological reviews.

[51]  J. Seume,et al.  Submicron droplet formation in the human lung , 2010 .

[52]  E. Cole,et al.  Characterization of infectious aerosols in health care facilities: An aid to effective engineering controls and preventive strategies , 1998, American Journal of Infection Control.

[53]  Y. Li,et al.  Role of air distribution in SARS transmission during the largest nosocomial outbreak in Hong Kong. , 2005, Indoor air.

[54]  M. P. Wan,et al.  Experimental Study of Dispersion and Deposition of Expiratory Aerosols in Aircraft Cabins and Impact on Infectious Disease Transmission , 2009 .

[55]  S. Kato,et al.  Study on transport characteristics of saliva droplets produced by coughing in a calm indoor environment , 2006 .