31P NMR spectroscopy of the human heart at 4 T: Detection of substantially uncontaminated cardiac spectra and differentiation of subepicardium and subendocardium

31 P NMR spectroscopy of the human heart was undertaken at 4 T to investigate whether spectra localized exclusively to the myocardium can be obtained. Utilizing a Fourier series window approach to spectroscopic imaging, we find that at least two layers across the anterior left ventricle wall can be detected, with voxel sizes of about 8 cm3.

[1]  Roger J. Ordidge,et al.  Image-selected in Vivo spectroscopy (ISIS). A new technique for spatially selective nmr spectroscopy , 1986 .

[2]  Hellmut Merkle,et al.  Spectroscopic imaging and spatial localization using adiabatic pulses and applications to detect transmural metabolite distribution in the canine heart , 1989, Magnetic resonance in medicine.

[3]  A. From,et al.  Correlation between transmural high energy phosphate levels and myocardial blood flow in the presence of graded coronary stenosis. , 1990, Circulation research.

[4]  Thomas H. Mareci,et al.  High-resolution magnetic resonance spectra from a sensitive region defined with pulsed field gradients , 1984 .

[5]  Michael Garwood,et al.  A modified rotating frame experiment based on a fourier series window function. Application to in vivo spatially localized NMR spectroscopy , 1985 .

[6]  P A Bottomley,et al.  Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy. , 1985, Science.

[7]  M. S. Silver,et al.  Highly selective {π}/{2} and π pulse generation , 1984 .

[8]  D. Twieg,et al.  Comparison of 31p mrs and 1h mri at 1.5 and 2.0 T , 1990, Magnetic resonance in medicine.

[9]  R. Balaban NMR spectroscopy of the heart: Part II , 1989 .

[10]  R. Balaban,et al.  NMR spectroscopy of the heart: Part II: NMR Spectroscopy of the Heart: Part II , 1989 .

[11]  M. Haas,et al.  Stimulation of K-C1 cotransport in rat red cells by a hemolytic anemia-producing metabolite of dapsone. , 1989, The American journal of physiology.

[12]  C J Hardy,et al.  Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance , 1990, Magnetic resonance in medicine.

[13]  Michael Garwood,et al.  Fourier series windows on and off resonance using multiple coils and longitudinal modulation and longitudinal modulation , 1987 .

[14]  K Uğurbil,et al.  Transmural high energy phosphate distribution and response to alterations in workload in the normal canine myocardium as studied with spatially localized 31P NMR spectroscopy , 1990, Magnetic resonance in medicine.

[15]  Haiying Liu,et al.  B1 voxel shifting of phase-modulated spectroscopic localization techniques , 1992 .

[16]  Thomas H. Mareci,et al.  Essential considerations for spectral localization using indirect gradient encoding of spatial information , 1991 .

[17]  Pines,et al.  Broadband and adiabatic inversion of a two-level system by phase-modulated pulses. , 1985, Physical review. A, General physics.

[18]  T. Mareci,et al.  Selective fourier transform localization , 1987, Magnetic resonance in medicine.

[19]  Hellmut Merkle,et al.  Transmural metabolite distribution in regional myocardial ischemia as studied with 31p NMR , 1989, Magnetic resonance in medicine.

[20]  B. Hubesch,et al.  Phosphorus‐31 magnetic resonance spectroscopy in humans by spectroscopic imaging: Localized spectroscopy and metabolite imaging , 1989, Magnetic resonance in medicine.

[21]  D. T. Pegg,et al.  Improved fourier series windows for localization in in vivo NMR spectroscopy , 1985 .

[22]  M. Weiner,et al.  Epicardial and endocardia1 localized 31p magnetic resonance spectroscopy: evidence for metabolic heterogeneity during regional ischemia , 1990, Magnetic resonance in medicine.

[23]  C. Hardy,et al.  Correcting human heart 31P NMR spectra for partial saturation. Evidence that saturation factors for PCr/ATP are homogeneous in normal and disease states , 1991 .

[24]  K. Hendrich,et al.  Metabolic consequences of coronary stenosis. Transmurally heterogeneous myocardial ischemia studied by spatially localized 31P NMR spectroscopy , 1989, NMR in biomedicine.

[25]  P. Allen,et al.  Application of continuous relaxation time distributions to the fitting of data from model systmes and excised tissue , 1991, Magnetic resonance in medicine.

[26]  M. Weiner,et al.  In vivo alterations of high-energy phosphates and intracellular pH during reversible ischemia in pigs: a 31P magnetic resonance spectroscopy study. , 1988, American heart journal.