Rheology effects on cross-stream diffusion in a Y-shaped micromixer

Abstract Micromixers are one of the essential components of modern bio-microfluidic devices. Since most bio-fluids are complex and their rheological behavior usually cannot be described by the Newton's law of viscosity, it is vital to take into account the non-linear behavior of the fluids being manipulated in these devices in the pertinent simulations. In this paper, the non-Newtonian rheology effects on mass transport in an electrokinetically driven Y-shaped micromixer of rectangular cross section are being investigated. The fluid rheological behavior is assumed to be efficiently described by the power-law viscosity model. The governing equations are solved in dimensionless form through a finite difference based numerical procedure for non-uniform grid. The results show that the deviations of the fluid rheological behavior from the predictions of the Newton's law of viscosity may result in significant alteration of the species concentration field, especially for thick EDLs. In this respect, a higher value of the flow behavior index gives rise to a thicker diffusion layer in the presence of a purely electroosmotic flow. Whereas the same is observed for a pressure assisted flow, the opposite is right in the presence of an adverse pressure gradient. Moreover, the diffusion layer extent is an increasing function of EDL thickness. The relevant functionality is pronounced by increasing the flow behavior index. In addition, the effect of decreasing both Peclet number and the rectangular geometry aspect ratio is to enhance the mixing efficiency.

[1]  Suman Chakraborty,et al.  Electroosmotically driven capillary transport of typical non-Newtonian biofluids in rectangular microchannels. , 2007, Analytica chimica acta.

[2]  K. Sharma,et al.  Non-Newtonian rheology of leukemic blood and plasma: are n and k parameters of power law model diagnostic? , 1992, Physiological chemistry and physics and medical NMR.

[3]  P. Cremer,et al.  Generating fixed concentration arrays in a microfluidic device , 2003 .

[4]  Thorsten Wohland,et al.  Investigations of the unsteady diffusion process in microchannels , 2011 .

[5]  P Yager,et al.  Theoretical analysis of molecular diffusion in pressure-driven laminar flow in microfluidic channels. , 2001, Biophysical journal.

[6]  Shili Wang,et al.  Electroosmotic pumps for microflow analysis. , 2009, Trends in analytical chemistry : TRAC.

[7]  Wolfgang Ehrfeld,et al.  Microreactors: New Technology for Modern Chemistry , 2000 .

[8]  M. Saidi,et al.  Pressure effects on electroosmotic flow of power-law fluids in rectangular microchannels , 2014 .

[9]  Paul Yager,et al.  Molecular diffusive scaling laws in pressure-driven microfluidic channels: deviation from one-dimensional Einstein approximations , 2002 .

[10]  Chun Yang,et al.  Analysis of electroosmotic flow of power-law fluids in a slit microchannel. , 2008, Journal of colloid and interface science.

[11]  F. Pinho,et al.  Analytical solution of mixed electro-osmotic/pressure driven flows of viscoelastic fluids in microchannels , 2009 .

[12]  S. De,et al.  Electroosmotic flow of power-law fluids at high zeta potentials , 2010 .

[13]  G. Whitesides,et al.  Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels , 2000 .

[14]  T. Mukherjee,et al.  Institute of Physics Publishing Journal of Micromechanics and Microengineering Systematic Modeling of Microfluidic Concentration Gradient Generators , 2022 .

[15]  Lynn F. Gladden,et al.  Simulation of miscible diffusive mixing in microchannels , 2007 .

[16]  Scaling law for cross-stream diffusion in microchannels under combined electroosmotic and pressure driven flow , 2013, Microfluidics and nanofluidics.

[17]  Daniel A. Beard,et al.  Taylor dispersion of a solute in a microfluidic channel , 2001 .

[18]  B. W. Webb,et al.  Fully developed electro-osmotic heat transfer in microchannels , 2003 .

[19]  B. Finlayson,et al.  Quantitative analysis of molecular interaction in a microfluidic channel: the T-sensor. , 1999, Analytical chemistry.

[20]  A. Mozafari,et al.  Electrokinetically driven fluidic transport of power-law fluids in rectangular microchannels , 2012 .

[21]  Transverse transport of solutes between co-flowing pressure-driven streams for microfluidic studies of diffusion/reaction processes , 2007, cond-mat/0702023.

[22]  B. W. Webb,et al.  The effect of viscous dissipation in thermally fully-developed electro-osmotic heat transfer in microchannels , 2004 .

[23]  D. Erickson,et al.  Influence of Surface Heterogeneity on Electrokinetically Driven Microfluidic Mixing , 2002 .

[24]  Hongjun Song,et al.  Cross-stream diffusion under pressure-driven flow in microchannels with arbitrary aspect ratios: a phase diagram study using a three-dimensional analytical model , 2012, Microfluidics and nanofluidics.

[25]  Jerry M Chen,et al.  Analysis and measurements of mixing in pressure-driven microchannel flow , 2006 .

[26]  Dongqing Li MICROFLUIDICS IN LAB-ON-A-CHIP: MODELS, SIMULATIONS AND EXPERIMENTS , 2005 .

[27]  Suman Chakraborty,et al.  Analytical solutions for velocity, temperature and concentration distribution in electroosmotic microchannel flows of a non-Newtonian bio-fluid , 2006 .

[28]  S. Chakraborty,et al.  Temperature Rise in Electroosmotic Flow of Typical Non-Newtonian Biofluids Through Rectangular Microchannels , 2014 .

[29]  S. Bhattacharjee,et al.  Electrokinetic and Colloid Transport Phenomena , 2006 .

[30]  Fernando T. Pinho,et al.  Steady viscoelastic fluid flow between parallel plates under electro-osmotic forces: Phan-Thien-Tanner model. , 2010, Journal of colloid and interface science.

[31]  Jungyul Park,et al.  Microfluidic mixing using periodically induced secondary potential in electroosmotic flow , 2011 .

[32]  T. Mukherjee,et al.  A model for laminar diffusion-based complex electrokinetic passive micromixers. , 2005, Lab on a chip.

[33]  Depthwise averaging approach to cross-stream mixing in a pressure-driven microchannel flow , 2005 .

[34]  J. Wikswo,et al.  Characterization of transport in microfluidic gradient generators , 2008 .

[35]  G. Karniadakis,et al.  Microflows and Nanoflows: Fundamentals and Simulation , 2001 .

[36]  D. Harvie,et al.  Modelling of interfacial mass transfer in microfluidic solvent extraction: part I. Heterogenous transport , 2013 .

[37]  Asterios Gavriilidis,et al.  Mixing characteristics of T-type microfluidic mixers , 2001 .

[38]  Dongqing Li,et al.  Modeling forced liquid convection in rectangular microchannels with electrokinetic effects , 1998 .

[39]  Stéphane Colin,et al.  Heat Transfer and Fluid Flow in Minichannels and Microchannels , 2005 .

[40]  S. Chakraborty,et al.  Effect of dispersion on the diffusion zone in two-phase laminar flows in microchannels. , 2012, Analytica chimica acta.

[41]  R. Pletcher,et al.  Computational Fluid Mechanics and Heat Transfer. By D. A ANDERSON, J. C. TANNEHILL and R. H. PLETCHER. Hemisphere, 1984. 599 pp. $39.95. , 1986, Journal of Fluid Mechanics.

[42]  S Chien,et al.  Effects of hematocrit and plasma proteins on human blood rheology at low shear rates. , 1966, Journal of applied physiology.