GARLIC USED AS AN ALTERNATIVE MEDICINE TO CONTROL DIABETIC MELLITUS IN ALLOXAN-INDUCED MALE RABBITS

Background: Herbal medicines are widely used because of their effectiveness, less side effects and low cost, so investigation on such agents from traditional medicinal plants has become more important in present day studies on medical sciences. Garlic is one of the most popular herbs used as an anti-diabetic agent. In present study possible anti diabetic effects of garlic were studied in alloxan-induced diabetic male rabbits, compared to normal control and diabetic control male rabbits. Methods: The blood samples were collected every third day and anti-diabetic effects of garlic were observed every time. The serum cholesterol level and body weight were also studied. With an aqueous extract of garlic (1% solution/Kg) body weight for 30 days significantly lowered serum glucose level (38.88%) and serum cholesterol level (57%). Results and Conclusion: The results indicate that garlic possesses a beneficial anti-hyperglycaemic effect in alloxan-induced rabbits.

[1]  L. Shaban,et al.  Anti-diabetic and hypolipidaemic properties of garlic (Allium sativum) in streptozotocin-induced diabetic rats , 2007, International Journal of Diabetes and Metabolism.

[2]  C. Douglas,et al.  Inhibitory effect of garlic extract on oral bacteria. , 2005, Archives of oral biology.

[3]  C. Lii,et al.  Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats. , 2005, European journal of pharmacology.

[4]  K. T. Augusti,et al.  Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats , 1996, Experientia.

[5]  C. Bailey,et al.  Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice , 1990, Diabetologia.

[6]  A. Meki,et al.  Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. , 2003, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[7]  J. Jamison.  Chapter 68 – Garlic (Allium Sativum) , 2003 .

[8]  S. Maulik,et al.  Effect of garlic on cardiovascular disorders: a review , 2002, Nutrition journal.

[9]  E. J. Staba,et al.  A commentary on the effects of garlic extraction and formulation on product composition. , 2001, The Journal of nutrition.

[10]  M. Ali,,et al.  Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet. , 2000, Prostaglandins, leukotrienes, and essential fatty acids.

[11]  Y. Nakata,et al.  [Effect of aged garlic extract (AGE) on hyperglycemia induced by immobilization stress in mice]. , 1999, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[12]  T. Bordia,et al.  An evaluation of garlic and onion as antithrombotic agents. , 1996, Prostaglandins, leukotrienes, and essential fatty acids.

[13]  K. T. Augusti.  Therapeutic values of onion (Allium cepa L.) and garlic (Allium sativum L.). , 1996, Indian journal of experimental biology.

[14]  M. Ali,,et al.  Consumption of a garlic clove a day could be beneficial in preventing thrombosis. , 1995, Prostaglandins, leukotrienes, and essential fatty acids.

[15]  K. T. Augusti,et al.  Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats. , 1995, Planta medica.

[16]  J. H. Slater,et al.  A quantitative assessment of the antimicrobial activity of garlic (Allium sativum) , 1993, World journal of microbiology & biotechnology.

[17]  K. T. Augusti,et al.  Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. , 1992, Indian journal of experimental biology.

[18]  E. Jung,et al.  Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. , 1991, International journal of clinical pharmacology, therapy, and toxicology.

[19]  Saleem Ahmad,et al.  The chemistry of alkyl thiosulfinate esters. 9. Antithrombotic organosulfur compounds from garlic: structural, mechanistic, and synthetic studies , 1986 .

[20]  K. T. Augusti,et al.  Studies on the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes. I. Hypoglycaemic action and enhancement of serum insulin effect and glycogen synthesis. , 1973, Indian journal of biochemistry & biophysics.